{"id":114563,"date":"2018-03-11T10:42:36","date_gmt":"2018-03-11T10:42:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilizacion-de-sistemas-microparticulares-como-adyuvantes-de-anta%c2%adgenos-sinteticos-antimalaricos\/"},"modified":"2018-03-11T10:42:36","modified_gmt":"2018-03-11T10:42:36","slug":"utilizacion-de-sistemas-microparticulares-como-adyuvantes-de-anta%c2%adgenos-sinteticos-antimalaricos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/peptidos\/utilizacion-de-sistemas-microparticulares-como-adyuvantes-de-anta%c2%adgenos-sinteticos-antimalaricos\/","title":{"rendered":"Utilizaci\u00f3n de sistemas microparticulares como adyuvantes de ant\u00edgenos sint\u00e9ticos antimal\u00e1ricos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Mata Gomez De Segura <\/strong><\/h2>\n<p>Este trabajo recoge la aplicaci\u00f3n de sistemas microparticulares como veh\u00edculo\/adyuvante de ant\u00edgenos sint\u00e9ticos antimal\u00e1ricos para potenciar y modular su inmunogenicidad. En un primer lugar se microencapsularon diferentes p\u00e9ptidos sint\u00e9ticos antimal\u00e1ricos y se caracterizaron las formulaciones desarrolladas; adem\u00e1s, se evalu\u00f3 y compar\u00f3 la respuesta inmunitaria inducida por dichos ant\u00edgenos formulados en micropart\u00edculas de plga frente a su vehiculizaci\u00f3n con otro adyuvante particulado, montanide. Tambi\u00e9n se evalu\u00f3 el efecto de la modificaci\u00f3n de dichos sistemas micropaticulares, como la incorporaci\u00f3n de alginato en la matriz polim\u00e9rica o la inclusi\u00f3n de secuencias rgd en la superficie, sobre su capacidad inmunopotenciadora e inmunomoduladora.Los resultados demostraronque tanto las micropart\u00edculas de plfa como el montanide administrados por v\u00eda sc presentan una capacidad similar para estimular respuestas de anticuerpos igg y sus subclases. Sin embargo, a pesar de que la funcionalidad de dichos anticuerpos sea superior en el caso de las micropart\u00edculas y de que el montanide potencie respuesta tipo th2 (ige total e inespec\u00edfica), este \u00faltimo induce a su vez una respuesta celular superior. Por otra parte, la inmunizaci\u00f3n id con las micropart\u00edculas de plga mejora la respuesta inmunitaria lograda por v\u00eda sc. Y supera al montanide tanto a nivel de secreci\u00f3n de anticuerpos, incluyendo anticuerpos citofilicos, como de respuesta celular. Adem\u00e1s, la incorporaci\u00f3n de alginato en la matriz polim\u00e9rica de las micropart\u00edculas de plga induce una potenciaci\u00f3n e inmunomodulaci\u00f3n de la respuesta inmunitaria tipoi th1. Por \u00faltimo, la inclusi\u00f3n de secuencias rgd en la superficie de las micropart\u00edculas provoca una eficiente vectorizaci\u00f3n hacia las c\u00e9lulas presentadoras de ant\u00edgenos, mejora su captaci\u00f3n y promueve la inducci\u00f3n de respuestas celulares.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilizaci\u00f3n de sistemas microparticulares como adyuvantes de ant\u00edgenos sint\u00e9ticos antimal\u00e1ricos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilizaci\u00f3n de sistemas microparticulares como adyuvantes de ant\u00edgenos sint\u00e9ticos antimal\u00e1ricos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Mata Gomez De Segura <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuela Igartua Olaechea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 bruno Fari\u00f1a espinosa <\/li>\n<li>emilia Mar\u00eda Barcia hernandez (vocal)<\/li>\n<li>Juan  Manuel Irache garreta (vocal)<\/li>\n<li>Jos\u00e9 angel Ruiz orgega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Mata Gomez De Segura Este trabajo recoge la aplicaci\u00f3n de sistemas microparticulares como veh\u00edculo\/adyuvante de ant\u00edgenos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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