{"id":114668,"date":"2018-03-11T10:42:46","date_gmt":"2018-03-11T10:42:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-polimorfismo-del-gen-il28b-sobre-la-bioqua%c2%admica-y-las-caractera%c2%adsticas-histologicas-de-la-infeccion-cronica-por-el-virus-de-la-hepatitis-c\/"},"modified":"2018-03-11T10:42:46","modified_gmt":"2018-03-11T10:42:46","slug":"influencia-del-polimorfismo-del-gen-il28b-sobre-la-bioqua%c2%admica-y-las-caractera%c2%adsticas-histologicas-de-la-infeccion-cronica-por-el-virus-de-la-hepatitis-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/influencia-del-polimorfismo-del-gen-il28b-sobre-la-bioqua%c2%admica-y-las-caractera%c2%adsticas-histologicas-de-la-infeccion-cronica-por-el-virus-de-la-hepatitis-c\/","title":{"rendered":"Influencia del polimorfismo del gen il28b sobre la bioqu\u00edmica y las caracter\u00edsticas histol\u00f3gicas de la infecci\u00f3n cr\u00f3nica por el virus de la hepatitis c."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Agreda Chinea <\/strong><\/h2>\n<p>Introducci\u00f3n. La patocronia de la infecci\u00f3n por el virus de la hepatitis c (vhc) es muy variable. El snp rs12979860 pr\u00f3ximo al gen il28b predice el aclaramiento viral espont\u00e1neo y la respuesta al tratamiento antiviral. Hay muy pocos datos sobre la influencia de este polimorfismo en la evoluci\u00f3n de la infecci\u00f3n cr\u00f3nica por vhc. hip\u00f3tesis.  El polimorfismo del gen il28b influye sobre la evoluci\u00f3n espont\u00e1nea de la hepatitis cr\u00f3nica por vhc (hcc).   objetivo. Investigar la distribuci\u00f3n del snp rs12979860 del gen il28b en pacientes con hcc y su relaci\u00f3n con los rasgos bioqu\u00edmicos, virol\u00f3gicos e histol\u00f3gicos de la enfermedad en todos sus estadios evolutivos. pacientes y m\u00e9todos. Se han incluido 1) pacientes con hcc no tratados y sometidos a biopsia hep\u00e1tica, y 2) pacientes con carcinoma hepatocelular (chc) sobre cirrosis por vhc. resultados.  3.1. Grupo 1 (hcc). 512 pacientes (292 con biopsia). Genotipo cc. 35,2 %, ct.  52,3 %, tt. 12,5 %. En el an\u00e1lisis multivariado los portadores del alelo t ten\u00edan valores significativamente m\u00e1s bajos de alt, m\u00e1s elevados de ggt y menor colesterolemia. El grado y el estadio histol\u00f3gicos no se relacionaron con el polimorfismo il28b. La esteatosis fue m\u00e1s frecuente e intensa en portadores del alelo t (or = 1,789, 95% ic = 1085  2950; chi2 tl = 5,194, p = 0,023). 3.2. Grupo 2 (chc). 134 pacientes. Genotipo rs12979860cc. 38,8 %, ct. 49,3 %; tt. 11,9 % tt. Esta distribuci\u00f3n no difiere de la del grupo de hcc.  conclusiones. El genotipo il28b rs12979860cc se asocia con concentraciones mayores de alt  y menores de ggt. La distribuci\u00f3n del polimorfismo no difiere entre los diferentes grados y estadios histol\u00f3gicos ni entre pacientes con hcc y chc. El estado de portador del alelo t se socia con la mayor frecuencia y severidad de esteatosis hep\u00e1tica en la hcc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del polimorfismo del gen il28b sobre la bioqu\u00edmica y las caracter\u00edsticas histol\u00f3gicas de la infecci\u00f3n cr\u00f3nica por el virus de la hepatitis c.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del polimorfismo del gen il28b sobre la bioqu\u00edmica y las caracter\u00edsticas histol\u00f3gicas de la infecci\u00f3n cr\u00f3nica por el virus de la hepatitis c. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Agreda Chinea <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Ladero Quesada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Ruiz de le\u00f3n san Juan <\/li>\n<li>Rafael Barcena marug\u00e1n (vocal)<\/li>\n<li>Carlos Jara sanchez (vocal)<\/li>\n<li>ricardo Moreno otero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Agreda Chinea Introducci\u00f3n. La patocronia de la infecci\u00f3n por el virus de la hepatitis c (vhc) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[986,139],"tags":[190961,39629,6504,227199,25707,13202],"class_list":["post-114668","post","type-post","status-publish","format-standard","hentry","category-complutense-de-madrid","category-medicina-interna","tag-antonio-ruiz-de-leon-san-juan","tag-carlos-jara-sanchez","tag-jose-maria-ladero-quesada","tag-marta-agreda-chinea","tag-rafael-barcena-marugan","tag-ricardo-moreno-otero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/114668","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=114668"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/114668\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=114668"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=114668"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=114668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}