{"id":114735,"date":"2013-07-10T00:00:00","date_gmt":"2013-07-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-intercambiador-cistina-glutamato-en-la-muerte-neuronal-tras-isquemia\/"},"modified":"2013-07-10T00:00:00","modified_gmt":"2013-07-10T00:00:00","slug":"papel-del-intercambiador-cistina-glutamato-en-la-muerte-neuronal-tras-isquemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/papel-del-intercambiador-cistina-glutamato-en-la-muerte-neuronal-tras-isquemia\/","title":{"rendered":"Papel del intercambiador cistina-glutamato en la muerte neuronal tras isquemia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Federico Nicolas Soria Lannes <\/strong><\/h2>\n<p>La liberaci\u00f3n excesiva de glutamato durante la isquemia provoca muerte neuronal tras la sobreactivaci\u00f3n de los receptores ionotr\u00f3picos de glutamato. No obstante, los mecanismos subyacentes a la alteraci\u00f3n de la homeostasis de este neurotransmisor, su fuente y su sitio de acci\u00f3n \u00c2\u00bfdentro o fuera de la sinapsis\u00c2\u00bf, todav\u00eda son tema de debate.El intercambiador cistina-glutamato, tambi\u00e9n conocido como sistema xc-, es un sistema de transporte de la membrana plasm\u00e1tica responsable de internalizar cistina a la c\u00e9lula y liberar glutamato al medio. Es la mayor fuente de cistina en la mayor\u00eda de los tipos celulares y es el principal regulador de la concentraci\u00f3n del glutamato extrasin\u00e1ptico en el sistema nervioso central (snc). Ya que la cistina es un amino\u00e1cido clave en la bios\u00edntesis de glutati\u00f3n, y el glutamato es el neurotransmisor m\u00e1s abundante del cerebro, el sistema xc- juega un papel crucial tanto en la defensa antioxidante como en la se\u00f1alizaci\u00f3n glutamat\u00e9rgica, dos procesos particularmente importantes en la isquemia.En este trabajo de tesis doctoral hemos analizado el papel del intercambiador cistina-glutamato en la muerte neuronal tras isquemia, utilizando modelos in vitro e in vivo en ratas. En un principio, hemos estudiado la expresi\u00f3n y funci\u00f3n de este transportador en los distintos tipos celulares del snc, resultando particularmente importante para la supervivencia de oligodendrocitos. Adem\u00e1s hemos localizado el sistema xc- en neuronas in vivo, donde se expresa fuera de la sin\u00e1psis. Tambi\u00e9n, presentamos evidencia de que la expresi\u00f3n y funci\u00f3n del intercambiador cistina-glutamato est\u00e1 incrementada tras isquemia qu\u00edmica en neuronas in vitro, y tras isquemia focal in vivo. Adem\u00e1s, el bloqueo farmacol\u00f3gico de dicho transportador aten\u00faa tanto la liberaci\u00f3n de glutamato en rodajas, como la muerte neuronal en cultivos organot\u00edpicos, ambas sometidas a privaci\u00f3n de ox\u00edgeno y glucosa (ogd). En este \u00faltimo modelo, el bloqueo de receptores nmda extrasin\u00e1pticos, y no as\u00ed los sin\u00e1pticos, fue neuroprotector tras ogd en organot\u00edpicos. En conjunto estos resultados sugieren que la isquemia regula positivamente la expresi\u00f3n y funci\u00f3n del intercambiador cistina-glutamato, lo que contribuye al incremento de la concentraci\u00f3n de glutamato extracelular y a la muerte neuronal excitot\u00f3xica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del intercambiador cistina-glutamato en la muerte neuronal tras isquemia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del intercambiador cistina-glutamato en la muerte neuronal tras isquemia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Federico Nicolas Soria Lannes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/10\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Domercq Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Martinez millan <\/li>\n<li>valent\u00edn Ce\u00f1a callejo (vocal)<\/li>\n<li>rosario Sanchez pernaute (vocal)<\/li>\n<li>isabel Perez ota\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Federico Nicolas Soria Lannes La liberaci\u00f3n excesiva de glutamato durante la isquemia provoca muerte neuronal tras la 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