{"id":114739,"date":"2013-09-10T00:00:00","date_gmt":"2013-09-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/dispositivos-polimericos-para-el-confinamiento-neuronal-y-registro-electrofisiologico-in-vitro-metodos-de-fabricacion-y-prueba-de-concepto\/"},"modified":"2013-09-10T00:00:00","modified_gmt":"2013-09-10T00:00:00","slug":"dispositivos-polimericos-para-el-confinamiento-neuronal-y-registro-electrofisiologico-in-vitro-metodos-de-fabricacion-y-prueba-de-concepto","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/dispositivos-polimericos-para-el-confinamiento-neuronal-y-registro-electrofisiologico-in-vitro-metodos-de-fabricacion-y-prueba-de-concepto\/","title":{"rendered":"Dispositivos polim\u00e9ricos para el confinamiento neuronal y registro electrofisiol\u00f3gico in vitro. m\u00e9todos de fabricaci\u00f3n y prueba de concepto"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Morales Carbajal <\/strong><\/h2>\n<p>La presente tesis trata del dise\u00f1o y fabricaci\u00f3n de un nuevo dispositivo para registrar la actividad el\u00e9ctrica neuronal espont\u00e1nea y estimulada farmacol\u00f3gicamente, en redes neuronales in vitro. La forma de operar esta herramienta es simple, su producci\u00f3n es de bajo coste y adem\u00e1s, ofrece una interfaz neurona-electrodo estable a largo plazo m\u00e1s all\u00e1 de lo posible con tecnolog\u00edas electrofisiol\u00f3gicas basadas en micropipeta. el dispositivo es una pieza polim\u00e9rica (polidimetilsiloxano) con dos compartimientos (zona de sembrado de los cultivos neuronales) comunicados entre s\u00ed a trav\u00e9s de un microcanal de dimensiones comparables a las dimensiones de los axones y dendritas. la actividad el\u00e9ctrica neuronal es registrable tras el crecimiento espont\u00e1neo de las neuritas dentro del microcanal (10 a 14 d\u00edas de sembradas las neuronas). Un par de electrodos, ubicados de extremo a extremo del microcanal, aprovechan las propiedades conductoras del medio extracelular para registrar los potenciales el\u00e9ctricos. la tecnolog\u00eda para microfabricar el dispositivo es una combinaci\u00f3n de la t\u00e9cnica de fotolitograf\u00eda (para crear los m\u00e1steres) y de la t\u00e9cnica de elastomer casting (para fabricar las piezas polim\u00e9ricas). el procesamiento de datos de las se\u00f1ales es un algoritmo matem\u00e1tico dise\u00f1ado para analizar la informaci\u00f3n registrada por el dispositivo; este algoritmo es ejecutado con el software de \u00abmatlab\u00bb. El procesamiento de datos asigna y contabiliza como potenciales de acci\u00f3n a las se\u00f1ales que sobrepasen el umbral predeterminado (170 \u00c2\u00b5v) de los registros y presenta los resultados en gr\u00e1ficas de barras de n\u00famero de potenciales de acci\u00f3n por unidad de tiempo (minuto).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dispositivos polim\u00e9ricos para el confinamiento neuronal y registro electrofisiol\u00f3gico in vitro. m\u00e9todos de fabricaci\u00f3n y prueba de concepto<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dispositivos polim\u00e9ricos para el confinamiento neuronal y registro electrofisiol\u00f3gico in vitro. m\u00e9todos de fabricaci\u00f3n y prueba de concepto <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Morales Carbajal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Polit\u00e9cnica de catalunya<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/10\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enric Claverol Tinture<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Sole pareta <\/li>\n<li>rosa Villa sanz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Morales Carbajal La presente tesis trata del dise\u00f1o y fabricaci\u00f3n de un nuevo dispositivo para registrar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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