{"id":114900,"date":"2018-03-11T10:43:10","date_gmt":"2018-03-11T10:43:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-metaloproteinasa-10-en-la-nefropata%c2%ada-y-retinopata%c2%ada-de-la-diabetes-tipo-1\/"},"modified":"2018-03-11T10:43:10","modified_gmt":"2018-03-11T10:43:10","slug":"papel-de-la-metaloproteinasa-10-en-la-nefropata%c2%ada-y-retinopata%c2%ada-de-la-diabetes-tipo-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/papel-de-la-metaloproteinasa-10-en-la-nefropata%c2%ada-y-retinopata%c2%ada-de-la-diabetes-tipo-1\/","title":{"rendered":"Papel de la metaloproteinasa-10 en la nefropat\u00eday retinopat\u00edade la diabetes tipo 1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Toni Garc\u00eda <\/strong><\/h2>\n<p>Hip\u00f3tesis: la concentraci\u00f3n elevada de metaloproteinasa-10 (mmp-10) en el suero de los pacientes con diabetes tipo 1 se asocia con el riesgo de padecer nefropat\u00eda y retinopat\u00eda diab\u00e9ticas. La mmp-10 est\u00e1 directamente implicada en el desarrollo de estas complicaciones.  m\u00e9todos: se determin\u00f3 la concentraci\u00f3n circulante de mmp-10 en 269 pacientes con diabetes tipo 1 y se estudi\u00f3 su asociaci\u00f3n con las complicaciones diab\u00e9ticas, ajustando por los factores de riesgo tradicionales: control gluc\u00e9mico, tiempo de evoluci\u00f3n de la enfermedad, hipertensi\u00f3n arterial, hipercolesterolemia y consumo de tabaco, as\u00ed como por sexo. Posteriormente se emple\u00f3 un modelo animal de diabetes inducida por streptozotocina, en ratones knock out en mmp-10 (mmp-10-\/-) y animales normales (mmp-10+\/+), para evaluar el desarrollo de la nefropat\u00eda y retinopat\u00eda diab\u00e9ticas en los mismos.  resultados: la concentraci\u00f3n elevada de mmp-10 (tercil m\u00e1s alto) en el suero de los pacientes con diabetes tipo 1 se asoci\u00f3 con un riesgo de tres a cuatro veces superior de presentar nefropat\u00eda y de casi seis veces de presentar retinopat\u00eda diab\u00e9tica proliferativa, independientemente de los factores de riesgo cl\u00e1sicos. No se encontr\u00f3 asociaci\u00f3n con la retinopat\u00eda diab\u00e9tica no proliferativa.  en el modelo murino, los animales mmp-10-\/- presentaron menor grado de nefropat\u00eda, caracterizada por niveles menores de creatinina y menor expansi\u00f3n mesangial, que los animales mmp-10+\/+. Adem\u00e1s, los animales mmp-10-\/- presentaron menor infiltraci\u00f3n renal de macr\u00f3fagos, sugiriendo que la mmp-10 contribuye a la respuesta inflamatoria implicada en la nefropat\u00eda. Los ratones mmp-10-\/- presentaron menor p\u00e9rdida de c\u00e9lulas ganglionares en la retina y mantuvieron el espesor en la capa nuclear interna en comparaci\u00f3n con los animales mmp-10+\/+, ambos hallazgos indican que los ratones mmp-10-\/- presentaban menor da\u00f1o retiniano. La inflamaci\u00f3n retiniana fue menor en los ratones mmp-10-\/-, como indican sus reducidos niveles de caspasa-1.  conclusiones: la mmp-10 est\u00e1 involucrada en el desarrollo de la nefropat\u00eda y retinopat\u00eda proliferativa en la diabetes tipo 1 y emerge como una potencial diana terap\u00e9utica para conseguir enlentecer la evoluci\u00f3n de la nefropat\u00eda y retinopat\u00eda diab\u00e9ticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la metaloproteinasa-10 en la nefropat\u00eday retinopat\u00edade la diabetes tipo 1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la metaloproteinasa-10 en la nefropat\u00eday retinopat\u00edade la diabetes tipo 1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Toni Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/11\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Nieves Diez Go\u00f1i<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Guillen grima <\/li>\n<li>Juan  Carlos Galofre ferrater (vocal)<\/li>\n<li>Luis Forga llenas (vocal)<\/li>\n<li>Manuel Aguilar diosdado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Toni Garc\u00eda Hip\u00f3tesis: la concentraci\u00f3n elevada de metaloproteinasa-10 (mmp-10) en el suero de los pacientes con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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