{"id":115003,"date":"2018-03-11T10:43:21","date_gmt":"2018-03-11T10:43:21","guid":{"rendered":""},"modified":"2018-03-11T10:43:21","modified_gmt":"2018-03-11T10:43:21","slug":"estudio-cla%c2%adnico-prospectivo-randomizado-doble-ciego-para-valorar-la-eficacia-de-los-antioxidantes-licopeno-y-acido-hidroxitirosol-versus-placebo-en-pacientes-con-sa%c2%adndrome-de-boca-ardient","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estomatologia-y-ortodoncia\/estudio-cla%c2%adnico-prospectivo-randomizado-doble-ciego-para-valorar-la-eficacia-de-los-antioxidantes-licopeno-y-acido-hidroxitirosol-versus-placebo-en-pacientes-con-sa%c2%adndrome-de-boca-ardient\/","title":{"rendered":"Estudio cl\u00ednico prospectivo randomizado doble ciego para valorar la eficacia de los antioxidantes (licopeno y \u00e1cido hidroxitirosol) versus placebo en pacientes con s\u00edndrome de boca ardiente"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paula Cristina Cano Carrillo <\/strong><\/h2>\n<p>Estudio cl\u00ednico prospectivo randomizado a doble ciego para valorar la eficacia de los antioxidantes (licopeno y \u00e1cido hidroxitirosol) versus placebo en pacientes con s\u00edndrome de boca ardiente.  resumen el s\u00edndrome de boca ardiente (sba) se caracteriza por una sensaci\u00f3n de ardor, escozor o picor generalizados en la cavidad bucal. Su etiolog\u00eda es desconocida a pesar de que hay indicios de la participaci\u00f3n de numerosos factores locales, sist\u00e9micos y psicol\u00f3gicos. objetivo: comprobar la eficacia cl\u00ednica del aceite de oliva mas licopeno sobre el ardor y escozor en pacientes con sba durante 3 meses.  materiales y m\u00e9todos: la poblaci\u00f3n de nuestro estudio incluye pacientes diagnosticados de s\u00edndrome de boca ardiente en la cl\u00ednica odontol\u00f3gica de la universidad de murcia. Se trata de un estudio a doble ciego randomizado frente a placebo. Se estudiaron 60 pacientes que cumpl\u00edan los criterios de inclusi\u00f3n, 30 de los cuales son tratados con aceite de oliva mas licopeno y los 30 restantes con placebo. Se analizaron las variables de sintomatolog\u00eda, calidad de vida oral mediante el ohip-14 y general sf36, hda y estr\u00e9s oxidativo en saliva.  resultados: respecto al eva global de ardor disminuye la sintomatolog\u00eda en ambos grupos al aplicar el producto. En relaci\u00f3n a la evoluci\u00f3n de la calidad de vida, mediante el test ohip-14, tanto en el grupo tratamiento como en el grupo placebo mejora de forma estad\u00edsticamente significativa (p&gt;0,05). Al estudiar la evoluci\u00f3n de la ansiedad y depresi\u00f3n, medida por h.A.D, no observamos diferencias estad\u00edsticamente significativas durante el seguimiento (p&lt;0,05). La calidad de vida general medida por test sf-36 observamos que dentro del grupo tratamiento s\u00f3lo hay diferencias significativas en el dominio de dolor corporal; no encontrando ninguna diferencia en el grupo placebo. En el an\u00e1lisis del estr\u00e9s oxidativo encontramos diferencias significativas en taa (actividad antioxidante total) en el grupo tratamiento. Finalmente el drenaje salival presenta una mejor\u00eda estad\u00edsticamente significativa tanto en el grupo tratamiento como en el grupo placebo tras los 3 meses de estudio.   conclusiones: el perfil bioqu\u00edmico no se modifica durante el periodo de tratamiento en ninguno de los grupos. El dolor global y la calidad de vida oral, mejor\u00f3 durante los 3 meses de tratamiento en ambos grupos. Con respecto al estr\u00e9s oxidativo medido en saliva, encontramos que en taa (actividad antioxidante total)  hay diferencias significativas en el grupo tratamiento.                         prospective clinical study randomized double-blind to assess the effectiveness of antioxidants (lycopene and hydroxytyrosol acid) versus placebo in patients with burning mouth syndrome.  abstract  burning mouth syndrome (bms) is characterized by a burning, stinging or itching widespread in the oral cavity. Its etiology is unknown although there is evidence of participation of many local factors, systemic and psychological.  objective: to assess the clinical efficacy of lycopene more olive oil on the burning and itching in patients with burning mouth syndrome for 3 months.  materials and methods: the study population included patients diagnosed with burning mouth syndrome in clinical dentistry, university of murcia. This is a randomized double-blind study versus placebo. We studied 60 patients who met the inclusion criteria, 30 of which are treated with more lycopene olive oil and the remaining 30 placebo. Variables were analyzed symptoms, oral quality of life through the overall ohip-14 and sf36, hda and oxidative stress in saliva.  results: regarding the global eva burning reduces symptoms in both groups when applying the product. Regarding the evolution of the quality of life through the test ohip-14, both in the treatment group as in the placebo group improved statistically significantly (p&gt;0.05). By studying the evolution of anxiety and depression, as measured by had, no statistically significant differences at follow up (p&lt;0.05). The overall quality of life as measured by sf-36 test in the group observed that treatment only significant differences in the bodily pain domain, finding no difference in the placebo group. In the analysis of oxidative stress significant differences in taa (total antioxidant activity) in the treatment group. Finally salivary drainage presents a statistically significant improvement in both the treatment group as in the placebo group after 3 months of study.   conclusions: the biochemical profile does not change during the treatment period in either group. Global pain and oral quality of life, improved during the 3 months of treatment in both groups. With regard to oxidative stress measured in saliva found in taa (total antioxidant activity) there are significant differences in the treatment group.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio cl\u00ednico prospectivo randomizado doble ciego para valorar la eficacia de los antioxidantes (licopeno y \u00e1cido hidroxitirosol) versus placebo en pacientes con s\u00edndrome de boca ardiente<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio cl\u00ednico prospectivo randomizado doble ciego para valorar la eficacia de los antioxidantes (licopeno y \u00e1cido hidroxitirosol) versus placebo en pacientes con s\u00edndrome de boca ardiente <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paula Cristina Cano Carrillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2013<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Pia Lopez Jornet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Calvo guirado <\/li>\n<li>Javier Guardia mu\u00f1oz (vocal)<\/li>\n<li>cristina Martinez conesa (vocal)<\/li>\n<li>gerardo G\u00f3mez moreno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paula Cristina Cano Carrillo Estudio cl\u00ednico prospectivo randomizado a doble ciego para valorar la eficacia de los 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