{"id":115038,"date":"2018-03-11T10:43:21","date_gmt":"2018-03-11T10:43:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/effects-of-alfa-lipoic-acid-on-lipid-metabolism-and-mitochondrial-biogenesis-in-adipocytes-study-of-the-molecular-mechanisms-involved\/"},"modified":"2018-03-11T10:43:21","modified_gmt":"2018-03-11T10:43:21","slug":"effects-of-alfa-lipoic-acid-on-lipid-metabolism-and-mitochondrial-biogenesis-in-adipocytes-study-of-the-molecular-mechanisms-involved","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-humana\/effects-of-alfa-lipoic-acid-on-lipid-metabolism-and-mitochondrial-biogenesis-in-adipocytes-study-of-the-molecular-mechanisms-involved\/","title":{"rendered":"Effects of alfa-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved"},"content":{"rendered":"

Tesis doctoral de Marta Fern\u00e1ndez Galilea <\/strong><\/h2>\n

α-lipoic acid (5-(1,2-dithiolan-3-yl)-pentanoic acid) is a natural occurring compound which possesses antioxidant properties. Moreover, anti-obesity properties in both rodents and humans have been attributed to α-lipoic acid being adipose tissue a target for this compound. In this context, the present study has demonstrated the ability of α-la to modulate lipid metabolism in both murine and human white adipocytes. Thus, α-la: 1) inhibits fatty acids uptake (through cd36 downregulation); 2) reduces fatty acids esterification into triglycerides (through dgat1 reduction); 3) decreases de novo lipogenesis (induced by inhibition of fas, scd1 and acc mediated by ampk activation); 4) stimulates lipolysis (mainly mediated by the phosphorylation of hsl through camp-mediated activation of pka, probably through the inhibition of adpla and pge2; 5) increases fatty acid oxidation machinery (cpt1 and acox) in white adipocytes; 6) promotes mitochondrial biogenesis by the activation of pgc-1α mediated by sirt1 and ampk activation; and 7) induces a brown-like remodelling in white subcutaneous adipocytes from overweight\/obese subjects. taking together all of these facts suggest that α-la remodels adipocyte metabolism towards oxidation rather than storage, and this could contribute to the anti-obesity properties of α-la.<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abEffects of alfa-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Effects of alfa-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved <\/li>\n
  • Autor:<\/strong>\u00a0 Marta Fern\u00e1ndez Galilea <\/li>\n
  • Universidad:<\/strong>\u00a0 Navarra<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2013<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Mar\u00eda Jes\u00fas Moreno Aliaga<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Mar\u00eda del puy Portillo baquedano <\/li>\n
        • ricardo Rueda cabrera (vocal)<\/li>\n
        • cedric Moro (vocal)<\/li>\n
        • Mar\u00eda Jos\u00e9 Iraburu elizalde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Marta Fern\u00e1ndez Galilea α-lipoic acid (5-(1,2-dithiolan-3-yl)-pentanoic acid) is a natural occurring compound which possesses antioxidant properties. Moreover, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,212,466,17749,1176],"tags":[227766,55797,18190,41611,227765,58011],"class_list":["post-115038","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-humana","category-metabolismo-energetico","category-navarra","category-nutrientes","tag-cedric-moro","tag-maria-del-puy-portillo-baquedano","tag-maria-jesus-moreno-aliaga","tag-maria-jose-iraburu-elizalde","tag-marta-fernandez-galilea","tag-ricardo-rueda-cabrera"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/115038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=115038"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/115038\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=115038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=115038"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=115038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}