{"id":11505,"date":"2018-03-09T08:56:54","date_gmt":"2018-03-09T08:56:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-la-tecnica-de-fiction-multicolor-aplicaciones-en-el-diagnostico-e-investigacion-de-los-linfomas-malignos\/"},"modified":"2018-03-09T08:56:54","modified_gmt":"2018-03-09T08:56:54","slug":"desarrollo-de-la-tecnica-de-fiction-multicolor-aplicaciones-en-el-diagnostico-e-investigacion-de-los-linfomas-malignos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-de-la-tecnica-de-fiction-multicolor-aplicaciones-en-el-diagnostico-e-investigacion-de-los-linfomas-malignos\/","title":{"rendered":"Desarrollo de la tecnica de fiction multicolor: aplicaciones en el diagnostico e investigacion de los linfomas malignos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Ignacio Martin Subero <\/strong><\/h2>\n<p>Las tecnicas interdisciplinares que permiten la caracterizaci\u00f3n fenot\u00edpica y genotipica de las celulas tumorales se estan estableciendo como herramientas importantes para el diagn\u00f3stico e investigaci\u00f3n de los tumores malignos. uno de estos metodos es la tecnica de fiction (fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms). esta tecnica permite analizar simultaneamente los aspectos morfologicos, inmunofenotipicos y geneticos de las celulas tumorales. Hasta la fecha las aplicaciones de la tecnica de fiction han estado limitadas por el escaso n\u00famero de sustancias fluorescentes utilizadas. En este trabajo, y para solucionar dicha limitaci\u00f3n, se ha desarrollado una tecnica denominada fiction multiculor (m-fiction),que adem\u00e1s de estudiar la morfolog\u00eda y el inmunofenotipo celulares,permite la detecci\u00f3n de alteraciones geneticas multiples. Se han desarrollado tres ensayos de m-fiction para el diagnostico de los linfomas no-hodgkin de celulas b(lnh-b), las neoplasias de celulas t(nct) y el linfoma anapl\u00e1sico de celulas grandes(lacg), mediante el uso de anticuerpos anti-cd20,-cd3 y alk, respectivamente, en combinaci\u00f3n con sondas de hibridaci\u00f3n para las alteraciones gen\u00e9ticas primarias asociadas a los citados linfomas. Para el linfoma de hodgkin, cuyas alteraciones geneticas asociadas son todavia una incognita, se dise\u00f1aron ensayos de fiction y m-fiction para estudiar la implicacion de los genes rel e igh. para demostrar la validez de la tecnica, los ensayos para los lnh-b, nct y lacg se aplicaron en controles negativos y positivos, estableciendo asi su aplicabilidad diagn\u00f3stica. En el linfoma de hodgkin(lh), se determin\u00f3 que tanto las translocaciones del gen igh como las amplificaciones de gen rel son dos de las alteraciones geneticas m\u00e1s frecuentes asociadas al lh. las aplicaciones de la tecnica de m-fiction no estan restringidas a las neoplasias hematol\u00f3gicas y, en un futuro pr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de la tecnica de fiction multicolor: aplicaciones en el diagnostico e investigacion de los linfomas malignos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de la tecnica de fiction multicolor: aplicaciones en el diagnostico e investigacion de los linfomas malignos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Ignacio Martin Subero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Jose Calasanz Abinzano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel angel Piris pinilla <\/li>\n<li>Luis Montuenga badia (vocal)<\/li>\n<li>brigitte Schlegelberger (vocal)<\/li>\n<li> De arce Miguel angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Ignacio Martin Subero Las tecnicas interdisciplinares que permiten la caracterizaci\u00f3n fenot\u00edpica y genotipica de las celulas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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