{"id":115156,"date":"2018-03-11T10:43:31","date_gmt":"2018-03-11T10:43:31","guid":{"rendered":""},"modified":"2018-03-11T10:43:31","modified_gmt":"2018-03-11T10:43:31","slug":"evaluation-of-protein-expression-signaling-and-treatment-induced-epigenetic-regulation-of-the-serotonin-5-ht2a-metabotropic-glutamate-mglu2-receptor-heterocomplex-in-postmortem-brain-of-schizophrenic","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/evaluation-of-protein-expression-signaling-and-treatment-induced-epigenetic-regulation-of-the-serotonin-5-ht2a-metabotropic-glutamate-mglu2-receptor-heterocomplex-in-postmortem-brain-of-schizophrenic\/","title":{"rendered":"Evaluation of protein expression, signaling and treatment-induced epigenetic regulation of the serotonin 5-ht2a\/metabotropic glutamate mglu2 receptor heterocomplex in postmortem brain of schizophrenic"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aintzane Garcia &#8212; <\/strong><\/h2>\n<p>La esquizofrenia es una enfermedad cr\u00f3nica que afecta al 1% de la poblaci\u00f3n mundial. A pesar de que su etiolog\u00eda es a\u00fan desconoc\u00eda, estudios epidemiol\u00f3gicos sugieren que factores tanto gen\u00e9ticos como ambientales favorecen el desarrollo de esta enfermedad. Los f\u00e1rmacos antipsic\u00f3ticos actuales no son capaces de remitir todos los s\u00edntomas de la esquizofrenia, dando lugar adem\u00e1s a un gran abanico de efectos adversos, lo que disminuye la adherencia al tratamiento. En este contexto, el objetivo principal de la presente tesis doctoral fue evaluar  la expresi\u00f3n de diferentes prote\u00ednas implicadas en la se\u00f1alizaci\u00f3n seroton\u00e9rgica y glutamat\u00e9rgica, as\u00ed como en la regulaci\u00f3n de esta se\u00f1alizaci\u00f3n, as\u00ed como caracterizar la diferente se\u00f1alizaci\u00f3n de los receptores y las modificaciones epigen\u00e9ticas que podr\u00edan estar alteradas en el cerebro postmortem de sujetos esquizofr\u00e9nicos. Tambi\u00e9n se evalu\u00f3 el efecto provocado por el tratamiento antipsic\u00f3tico. Para ello, se emplearon las siguientes t\u00e9cnicas: western blot, qrt-pcr, antibody-capture [35s]gtp\u00c2\u00bfs spa e inmunoprecipitaci\u00f3n de cromatina.        Los diferentes resultados obtenidos en el estudio apoyan la presencia de una desregulaci\u00f3n en el heterocomplejo 5-ht2ar\/mglu2r en esquizofrenia. Adem\u00e1s, tambi\u00e9n sugieren que las alteraciones epigen\u00e9ticas provocadas por f\u00e1rmacos antipsic\u00f3ticos at\u00edpicos podr\u00edan ser la base de la resistencia al tratamiento presentada por un 30% de los pacientes. En conjunto, estos resultados alientan la b\u00fasqueda de nuevas dianas para f\u00e1rmacos antipsic\u00f3ticos que podr\u00edan actuar en la regulaci\u00f3n epigen\u00e9tica de los receptores para neurotransmisores y de sus v\u00edas de se\u00f1alizaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluation of protein expression, signaling and treatment-induced epigenetic regulation of the serotonin 5-ht2a\/metabotropic glutamate mglu2 receptor heterocomplex in postmortem brain of schizophrenic<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluation of protein expression, signaling and treatment-induced epigenetic regulation of the serotonin 5-ht2a\/metabotropic glutamate mglu2 receptor heterocomplex in postmortem brain of schizophrenic <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aintzane Garcia &#8212; <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/01\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ane Miren Gabilondo Urkijo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Leza cerro <\/li>\n<li>Carlos Matute almau (vocal)<\/li>\n<li>Jos\u00e9 Luis Moreno carboneros (vocal)<\/li>\n<li>Mar\u00eda  isabel Loza garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aintzane Garcia &#8212; La esquizofrenia es una enfermedad cr\u00f3nica que afecta al 1% de la poblaci\u00f3n mundial. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[957,12909,1408],"tags":[227945,10557,10024,227946,134330,9145],"class_list":["post-115156","post","type-post","status-publish","format-standard","hentry","category-farmacologia","category-pais-vasco-euskal-herriko-unibertsitatea","category-psiquiatria","tag-aintzane-garcia","tag-ane-miren-gabilondo-urkijo","tag-carlos-matute-almau","tag-jose-luis-moreno-carboneros","tag-juan-carlos-leza-cerro","tag-maria-isabel-loza-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/115156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=115156"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/115156\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=115156"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=115156"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=115156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}