{"id":115166,"date":"2018-03-11T10:43:31","date_gmt":"2018-03-11T10:43:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-cla%c2%adnico-patologica-y-biomarcadores-de-estres-oxidativo-en-pacientes-con-liquen-plano-oral\/"},"modified":"2018-03-11T10:43:31","modified_gmt":"2018-03-11T10:43:31","slug":"evaluacion-cla%c2%adnico-patologica-y-biomarcadores-de-estres-oxidativo-en-pacientes-con-liquen-plano-oral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estomatologia-y-ortodoncia\/evaluacion-cla%c2%adnico-patologica-y-biomarcadores-de-estres-oxidativo-en-pacientes-con-liquen-plano-oral\/","title":{"rendered":"Evaluaci\u00f3n cl\u00ednico patol\u00f3gica y biomarcadores de estr\u00e9s oxidativo en pacientes con liquen plano oral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alvaro Pons-fuster Lopez <\/strong><\/h2>\n<p>Evaluaci\u00f3n cl\u00ednico patol\u00f3gica y biomarcadores de estr\u00e9s oxidativo en pacientes con liquen plano oral resumen  introducci\u00f3n el liquen plano oral  (lpo) es probablemente la enfermedad no infecciosa m\u00e1s frecuente de la mucosa oral .La preValencia del liquen plano en la poblaci\u00f3n general se estima entre un 0&apos;2 y un 1&apos;9%. En la actualidad, se considera que la lpo es un proceso inmunol\u00f3gico multifactorial con factores gen\u00e9ticos, psicol\u00f3gicos, infecciosos, etc., Que podr\u00edan actuar como agentes causales o como precipitantes del proceso. Las manifestaciones cl\u00ednicas se presentan como patrones (erosivos) ulcerosos, atr\u00f3ficos, reticulares, papulares y en placas. La posible malignizaci\u00f3n del liquen plano oral (lpo) sigue en la actualidad como un tema de controversia, este riesgo de malignizaci\u00f3n del liquen plano oral sugiere la realizaci\u00f3n de nuevas investigaciones a fin de determinar los factores involucrados en este proceso. objetivos. Los objetivos fueron realizar un estudio cl\u00ednico de las lesiones de liquen plano oral su asociaci\u00f3n con enfermedades autoinmunes e investigar condiciones de estr\u00e9s oxidativo en saliva  material y m\u00e9todos se seleccionaron 130 pacientes con liquen plano oral que cumplen los criterios de inclusi\u00f3n .En los 130 pacientes de lpo diagnosticados cl\u00ednica e histopatologicamente se encontr\u00f3 que el tipo cl\u00ednico de presentaci\u00f3n m\u00e1s frecuente fue el reticular.  resultados existe una asociaci\u00f3n estad\u00edsticamente significativa entre la forma de presentaci\u00f3n y la sintomatolog\u00eda referida por el paciente . La lesi\u00f3n reticular es la forma m\u00e1s frecuente de lpo que aparece como una red de estr\u00edas blancas superpuestas, seguidas de patrones (erosivos) ulcerosos, atr\u00f3ficos y placas. Encontramos la presencia de mayor numero de enfermedades autoinmunes 0.07% (10 \/130) en pacientes con olp que en que el grupo control 0,04% (6 \/130) encontramos, la correlaci\u00f3n negativa significativa entre la saliva capacidad antioxidante total y los niveles de mda en lpo.  conclusi\u00f3n encontramos la presencia de mayor numero de enfermedades autoinmunes en pacientes con olp que en que el grupo control.Encontramos, la correlaci\u00f3n negativa significativa entre la saliva capacidad antioxidante total y los niveles de mda en lpo.   abstract  oral lichen planus (olp) is probably the most common non-infectious disease of the oral mucosa. Lichen planus prevalence in the general population is estimated between 0.2 and 1.9%. At present, it is considered that the lpo is a multifactorial immune process with genetic, psychological, infections factors which could act as causal agents or as precipitating the process. the clinical manifestations are presented as patterns: ulcer (erosive), atrophic, reticular, papular and in plaques. The reticular lesion is the most common form of lpo which appears as a network of overlapping white streaks, followed by the ulcer (erosive) patterns, then atrophic and finally, plaques. The lpo appears frequently on both sides of the buccal mucosa, but it can also appear in the tongue, gums, or multiple sites. The malignant potential of olp continues today as a controversial issue and the risk of malignant transformation of oral lichen planus suggests further research to determine the factors involved in this process. objectives the objectives of this study were to conduct a clinical study of the lesions of olp, their association with autoimmune diseases and investigate oxidative stress conditions. material and methods  a study was conducted in 130 patients with oral lichen planus who met the inclusion criteria who were diagnosed clinically and histopathologically. We found that the most frequent clinical type was the reticular ones. result  there is a statistically significant association between the type of presentation and the symptoms reported by the patient. We found the presence of greater number of autoimmune diseases 0.07 % (10\/130) in patients with olp than in the control group 0.04 % (6\/130). We found significant negative correlation between total antioxidant capacity of saliva and mda levels in lpo conclusion we found the presence of greater number of autoimmune diseases  in patients with olp than in the control group we found significant negative correlation between total antioxidant capacity of saliva and mda levels in lpo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluaci\u00f3n cl\u00ednico patol\u00f3gica y biomarcadores de estr\u00e9s oxidativo en pacientes con liquen plano oral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluaci\u00f3n cl\u00ednico patol\u00f3gica y biomarcadores de estr\u00e9s oxidativo en pacientes con liquen plano oral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alvaro Pons-fuster Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Pia Lopez Jornet<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ambrosio Bernabeu esclapez <\/li>\n<li>Marta Camps raga (vocal)<\/li>\n<li>arturo Sanchez perez (vocal)<\/li>\n<li>celia Haya fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvaro Pons-fuster Lopez Evaluaci\u00f3n cl\u00ednico patol\u00f3gica y biomarcadores de estr\u00e9s oxidativo en pacientes con liquen plano oral [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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