{"id":115199,"date":"2018-03-11T10:43:36","date_gmt":"2018-03-11T10:43:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/infeccion-por-el-virus-del-papiloma-humano-en-mujeres-con-lesion-intraepitelial-cervical-aspectos-virologicos-y-clinicopatologicos\/"},"modified":"2018-03-11T10:43:36","modified_gmt":"2018-03-11T10:43:36","slug":"infeccion-por-el-virus-del-papiloma-humano-en-mujeres-con-lesion-intraepitelial-cervical-aspectos-virologicos-y-clinicopatologicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ginecologia\/infeccion-por-el-virus-del-papiloma-humano-en-mujeres-con-lesion-intraepitelial-cervical-aspectos-virologicos-y-clinicopatologicos\/","title":{"rendered":"Infecci\u00f3n por el virus del papiloma humano en mujeres con lesi\u00f3n intraepitelial cervical: aspectos virol\u00f3gicos y clinicopatol\u00f3gicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Moreno Docon <\/strong><\/h2>\n<p>Resumen  objetivos: en la actualidad, se conoce bien la relaci\u00f3n que existe entre la infecci\u00f3n por el virus del papiloma humano (vph) y las lesiones precursoras del c\u00e1ncer cervical. El principal objetivo de este estudio fue conocer la preValencia general de la infecci\u00f3n por vph y estudiar los genotipos m\u00e1s frecuentes en mujeres con lesi\u00f3n intraepitelial cervical en la regi\u00f3n de murcia. Por otra parte, se ha evaluado la utilidad de la detecci\u00f3n de vph como marcador pron\u00f3stico de enfermedad residual en mujeres tratadas por lesi\u00f3n cervical de alto grado (cin2+).  material y m\u00e9todos: se estudiaron muestras cl\u00ednicas procedentes de 3.752 pacientes que tras una exploraci\u00f3n ginecol\u00f3gica presentaron un resultado citol\u00f3gico anormal. Este estudio se realiz\u00f3 durante un periodo de 5 a\u00f1os (2008-2012), en un contexto de cribado asistencial oportunista, al no existir un modelo de cribado poblacional en nuestra comunidad. La detecci\u00f3n de adn del vph se realiz\u00f3 mediante la t\u00e9cnica de captura de h\u00edbridos, mientras que la detecci\u00f3n y tipado de vph se realiz\u00f3 mediante una t\u00e9cnica de pcr microarray.  resultados: en nuestro estudio, encontramos que la tasa de detecci\u00f3n de vph fue del 53,5% en ascus, 73,2% en lsil y 78,9% en hsil.  Los cuatro genotipos m\u00e1s frecuentes encontrados fueron los tipos 16 (31,1%), 31 (13,5%), 51 (13,4%) y el 53 (11,8%). La preValencia del vph 16 aument\u00f3 significativamente con el grado de la lesi\u00f3n citol\u00f3gica (p &lt; 0,0001). El vph 18 se detect\u00f3 con una baja frecuencia (5,7%), datos en concordancia con otros estudios publicados en nuestro pa\u00eds. No encontramos diferencias significativas entre el n\u00famero de tipos de vph y el grado de severidad de la lesi\u00f3n cervical. La introducci\u00f3n del test de vph en el seguimiento de mujeres tratadas mediante escisi\u00f3n con asa de diatermia, dada su elevada sensibilidad (93,7%) y valor predictivo negativo (97,3%), permite que estas mujeres pueden realizar su seguimiento mediante un protocolo de cribado convencional cada 3-5 a\u00f1os.   abstract  objetives: at present, the relationship between human papillomavirus (hpv) infection and cervical preneoplasic lesions is well known. The aim of this study was to determine the overall prevalence of hpv infection, and study the most frequent genotypes in women with cervical intraepithelial lesion in the region of murcia. Moreover, we evaluated the usefulness of hpv detection as a prognostic marker of residual disease in women treated for high-grade cervical lesions (cin2+).  material and methods: we studied 3.752 clinical samples from patients after gynecological examination which showed an abnormal cytology result. This study was conducted over a period of five years (2008-2012), in a context of opportunistic screening in the absence of a model for population screening in our community. Detection of hpv dna was performed by hybrid capture technique, whereas hpv detection and typing was performed by microarray-pcr.   results : in our study we found that hpv detection rate was 53.5% in ascus , 73.2 % in lsil and 78.9 % in hsil . The four most common genotypes found were types 16 ( 31.1 % ) , 31 ( 13.5 % ) , 51 ( 13.4%) and 53 ( 11.8 % ) . The prevalence of hpv 16 increased significantly with the degree of cervical lesion (p &lt;0.0001). The hpv 18 was detected with a low frequency (5.7 %), according to data published in other studies in our country. There are no significant differences between the number of hpv types and degree of severity of the cervical lesion. The introduction of hpv testing in the monitoring of women treated by diathermy loop excision , given its high sensitivity (93.7 % ) and negative predictive value ( 97.3 % ) , allows these women to follow it up with a conventional screening protocol every 3-5 years.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Infecci\u00f3n por el virus del papiloma humano en mujeres con lesi\u00f3n intraepitelial cervical: aspectos virol\u00f3gicos y clinicopatol\u00f3gicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Infecci\u00f3n por el virus del papiloma humano en mujeres con lesi\u00f3n intraepitelial cervical: aspectos virol\u00f3gicos y clinicopatol\u00f3gicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Moreno Docon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/01\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Segovia Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 angel Garc\u00eda rodr\u00edguez <\/li>\n<li>Juan  Jos\u00e9 Parrilla paricio (vocal)<\/li>\n<li>Juan  Luis Mu\u00f1oz bellido (vocal)<\/li>\n<li>Jos\u00e9 Prieto prieto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Moreno Docon Resumen objetivos: en la actualidad, se conoce bien la relaci\u00f3n que existe entre la 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