{"id":115386,"date":"2018-03-11T10:43:53","date_gmt":"2018-03-11T10:43:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-aglomeracion-macromolecular-modula-las-propiedades-conformacionales-y-funcionales-del-sistema-dnak\/"},"modified":"2018-03-11T10:43:53","modified_gmt":"2018-03-11T10:43:53","slug":"la-aglomeracion-macromolecular-modula-las-propiedades-conformacionales-y-funcionales-del-sistema-dnak","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/la-aglomeracion-macromolecular-modula-las-propiedades-conformacionales-y-funcionales-del-sistema-dnak\/","title":{"rendered":"La aglomeraci\u00f3n macromolecular modula las propiedades conformacionales y funcionales del sistema dnak"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Garbi\u00f1e Celaya Garavilla <\/strong><\/h2>\n<p>El sistema de chaperonas dnak de e. Coli es una de las armas de defensa m\u00e1s potentes contra la formaci\u00f3n de agregados proteicos intracelulares y est\u00e1 constituido por dnak (hsp70) y sus cochaperonas dnaj (hsp40) y grpe (nef). La concentraci\u00f3n de macromol\u00e9culas del citosol bacteriano donde este sistema lleva a cabo sus funciones se sit\u00faa en torno a 300 &#8211; 400 g\/l. Los modelos te\u00f3ricos predicen que la aglomeraci\u00f3n macromolecular afectar\u00e1 al plegamiento proteico y a la reactivaci\u00f3n de agregados mediados por chaperonas, ya que favorece la asociaci\u00f3n entre macromol\u00e9culas y la agregaci\u00f3n proteica. El objetivo de la presente tesis doctoral fue analizar el efecto de la aglomeraci\u00f3n macromolecular sobre las propiedades conformacionales y funcionales del sistema dnak. Se comprob\u00f3 que en presencia de un agente aglomerante inerte el equilibrio conformacional de dnak est\u00e1 desplazado hacia una forma m\u00e1s compacta que presenta mayor afinidad por dnaj. A su vez, la estructura de la cochaperona sufre un reordenamiento dependiente de la temperatura. Sin embargo, la asociaci\u00f3n con grpe se vio ligeramente desfavorecida. Estas variaciones de afinidad tienen consecuencias funcionales, ya que estrechan el rango de concentraciones en las que la reactivaci\u00f3n de agregados es \u00f3ptima. Esto explica el estricto control que la c\u00e9lula ejerce para mantener las concentraciones relativas de los componentes del sistema dnak. Adem\u00e1s, la aglomeraci\u00f3n macromolecular permite la competencia de grpe y clpb para unirse a dnak, lo que facilitar\u00eda la interacci\u00f3n de dnak con la desagregasa en condiciones de estr\u00e9s, y con grpe en condiciones fisiol\u00f3gicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La aglomeraci\u00f3n macromolecular modula las propiedades conformacionales y funcionales del sistema dnak<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La aglomeraci\u00f3n macromolecular modula las propiedades conformacionales y funcionales del sistema dnak <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Garbi\u00f1e Celaya Garavilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/03\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo Muga Villate<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alicia Alonso izquierdo <\/li>\n<li>german Rivas caballero (vocal)<\/li>\n<li>Jos\u00e9 Manuel Sanchez ruiz (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Valpuesta moralejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garbi\u00f1e Celaya Garavilla El sistema de chaperonas dnak de e. Coli es una de las armas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[115,12909,3178],"tags":[13242,70980,228291,51885,22210,49522],"class_list":["post-115386","post","type-post","status-publish","format-standard","hentry","category-bioquimica-molecular","category-pais-vasco-euskal-herriko-unibertsitatea","category-proteinas","tag-alicia-alonso-izquierdo","tag-arturo-muga-villate","tag-garbine-celaya-garavilla","tag-german-rivas-caballero","tag-jose-manuel-sanchez-ruiz","tag-jose-maria-valpuesta-moralejo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/115386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=115386"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/115386\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=115386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=115386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=115386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}