{"id":115392,"date":"2018-03-11T10:43:53","date_gmt":"2018-03-11T10:43:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-isoformas-de-endoglina-en-el-linaje-mieloide\/"},"modified":"2018-03-11T10:43:53","modified_gmt":"2018-03-11T10:43:53","slug":"papel-de-las-isoformas-de-endoglina-en-el-linaje-mieloide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/papel-de-las-isoformas-de-endoglina-en-el-linaje-mieloide\/","title":{"rendered":"Papel de las isoformas de endoglina en el linaje mieloide."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mikel Aristorena San Adrian <\/strong><\/h2>\n<p>Endoglina es una glicoprote\u00edna de membrana con un papel crucial en el remodelado vascular y la angiog\u00e9nesis. Habi\u00e9ndose descrito su funci\u00f3n e implicaciones fisiopatol\u00f3gicas principalmente en el \u00e1mbito de la c\u00e9lula endotelial, su papel en el linaje mieloide, donde tambi\u00e9n se expresa, est\u00e1 todav\u00eda por elucidar. En la presente memoria se aborda el estudio de las dos isoformas de endoglina en la l\u00ednea promonoc\u00edtica u937, mediante an\u00e1lisis prote\u00f3mico silac. Al analizar las prote\u00ednas alteradas debido a la acci\u00f3n de las isoformas de endoglina, se ha identificado a la isoforma corta de endoglina (engs) como un marcador de senescencia en macr\u00f3fagos, observ\u00e1ndose alteraciones en adhesi\u00f3n, supervivencia, proliferaci\u00f3n o acumulaci\u00f3n de especies reactivas de ox\u00edgeno. Los an\u00e1lisis in vivo e in vitro realizados, confirman la validez del desequilibrio entre la expresi\u00f3n de la isoforma corta frente a la mayoritaria (isoforma larga, engl) como un marcador del estado envejecido en estas c\u00e9lulas. Adem\u00e1s, se ha observado una polarizaci\u00f3n preferencial de los transfectantes de endoglina corta hacia el fenotipo macrof\u00e1gico anti-inflamatorio-m2 y una peor respuesta generalizada a est\u00edmulos pro-inflamatorios-m1. Este comportamiento se puede englobar dentro del deterioro en la respuesta inmune innata asociada a la inmunosenescencia. por otra parte se ha analizado el perfil liberaci\u00f3n de una tercera forma de endoglina, la endoglina soluble. Se ha identificado por primera vez esta forma soluble de endoglina como un marcador de polarizaci\u00f3n de macr\u00f3fagos m1. Adem\u00e1s se ha descrito un nuevo mecanismo proteol\u00edtico de liberaci\u00f3n de endoglina de membrana por medio de la metaloproteasa de macr\u00f3fagos mmp12. Se ha establecido por tanto una relaci\u00f3n directa entre endoglina soluble y mmp12 como marcadores de respuesta inflamatoria en macr\u00f3fagos, un hallazgo que est\u00e1 apoyado por el hecho de que ambos factores solubles est\u00e1n aumentados en enfermedades que tienen asociado un proceso inflamatorio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las isoformas de endoglina en el linaje mieloide.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las isoformas de endoglina en el linaje mieloide. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mikel Aristorena San Adrian <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/03\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Blanco L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li> Escribese alonso Mar\u00eda Marta (vocal)<\/li>\n<li>teresa Bell\u00f3n heredia (vocal)<\/li>\n<li>patricio Aller tresguerres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mikel Aristorena San Adrian Endoglina es una glicoprote\u00edna de membrana con un papel crucial en el remodelado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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