{"id":11541,"date":"2018-03-09T08:56:57","date_gmt":"2018-03-09T08:56:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genetica-de-la-proliferacion-intracelular-de-salmonella-enterica-en-celulas-eucarioticas-nofagociticas\/"},"modified":"2018-03-09T08:56:57","modified_gmt":"2018-03-09T08:56:57","slug":"genetica-de-la-proliferacion-intracelular-de-salmonella-enterica-en-celulas-eucarioticas-nofagociticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/genetica-de-la-proliferacion-intracelular-de-salmonella-enterica-en-celulas-eucarioticas-nofagociticas\/","title":{"rendered":"Gen\u00e9tica de la proliferaci\u00f3n intracelular de salmonella enterica en c\u00e9lulas eucarioticas nofagociticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Cano Gonz\u00e1lez <\/strong><\/h2>\n<p>Salmonella enterica es un pat\u00f3geno intracelular que puede ocasionar gastroenteritis,enfermedad sistemica o ambas en humanos y una gran variedad de animales. La disponibilidad de cultivos celulares del hospedador y la factilidad con la que salmonella enterica invade alguno de ellos ha permitido el uso de cultivos celulares como modelos in vitro para el estudio de la biolog\u00eda de tres etapas claves en el proceso infectivo. La supervivencia en macr\u00f3fagos,la invasi\u00f3n de c\u00e9lulas no fagoc\u00edticas y la proliferaci\u00f3n intracelular en c\u00e9lulas no fagoc\u00edticas.  en esta tesis se han usado fibroblastos de rat\u00f3n, nrk, como prototipo de c\u00e9lulas eucari\u00f3ticas y se ha recurrido a la gen\u00e9tica bacteriana cl\u00e1sica para identificar funciones de salmonella enterica que intervienen en la interaci\u00f3n con el hospedador mediante la b\u00fasqueda de mutantes que proliferasen en el interior de c\u00e9lulas nrk. De esta manera se ha determinado que salmonella enterica posee sistemas de autocontrol que impiden la proliferaci\u00f3n del pat\u00f3ngeo enlineas celulares no permisivas. La m\u00e1s importante parece ser el sistema phop-phoq aunque tambi\u00e9n intervienen otros reguladores del virulencia como slya, spvr, rpos. Adem\u00e1s se describe por primera vez una prote\u00edna, iga que tambi\u00e9n intervien en el control de la proliferaci\u00f3n intracelular en c\u00e9lulas no permisivas y que ejerce este efecto a trav\u00e9s del sistema de dos componentes rcsb-rcsc. Esta prot\u00e9ina es tambi\u00e9n necesaria para la virulencia en el modelo animal del rat\u00f3n y es una funci\u00f3n esencial para la viabilidad de la bacterias como se demustra por el hecho de que es imposible obtener un mutante nulo en el gen iga. En la viabilidad intracelular del pat\u00f3geno participan el fectos sigma rpoe y el sistema de secreci\u00f3n de tipo iii codificado en la isal 2 de patogenicidad de salmonella ent\u00e9rica.  la permanencia prolongada de salmonella enterica en elinterior de c\u00e9lulas no permisivas requiere una adaptaci\u00f3n al metabolis<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Gen\u00e9tica de la proliferaci\u00f3n intracelular de salmonella enterica en c\u00e9lulas eucarioticas nofagociticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Gen\u00e9tica de la proliferaci\u00f3n intracelular de salmonella enterica en c\u00e9lulas eucarioticas nofagociticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Cano Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep Casadesus Pursals<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Vazquez  boland <\/li>\n<li>Jos\u00e9 Berenguer Carlos (vocal)<\/li>\n<li>Carlos Guman (vocal)<\/li>\n<li>Mar\u00eda Torotolero Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Cano Gonz\u00e1lez Salmonella enterica es un pat\u00f3geno intracelular que puede ocasionar gastroenteritis,enfermedad sistemica o ambas en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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