{"id":115497,"date":"2014-07-04T00:00:00","date_gmt":"2014-07-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-los-complejos-nucleoplasmina-histona-y-su-papel-en-el-remodelado-de-la-cromatina\/"},"modified":"2014-07-04T00:00:00","modified_gmt":"2014-07-04T00:00:00","slug":"caracterizacion-de-los-complejos-nucleoplasmina-histona-y-su-papel-en-el-remodelado-de-la-cromatina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/caracterizacion-de-los-complejos-nucleoplasmina-histona-y-su-papel-en-el-remodelado-de-la-cromatina\/","title":{"rendered":"Caracterizaci\u00f3n de los complejos nucleoplasmina: histona y su papel en el remodelado de la cromatina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Noelia Fernandez Rivero <\/strong><\/h2>\n<p>La nucleoplasmina (np o npm2) es una chaperona de histonas presente en losoocitos (onp) y huevos (enp) de xenopus laevis. Esta prote\u00edna se hiperfosforila durante lamaduraci\u00f3n del oocito a huevo, lo cual es esencial para su actividad. En el oocito, la npune y almacena los d\u00edmeros h2a\/h2b y, tras la fecundaci\u00f3n, media el ensamblaje denucleosomas en la cromatina esperm\u00e1tica al retirar las prote\u00ednas b\u00e1sicas espec\u00edficas delespermatozoide (ssbps) y a\u00f1adir los d\u00edmeros h2a\/h2b. Adem\u00e1s, la np est\u00e1 implicada enel remodelado de la cromatina al inicio de la embriog\u00e9nesis. Al igual que otras chaperonasde histonas, la np es capaz de unir diferentes tipos de ligandos b\u00e1sicos como las histonas\u00c2\u00bflinker\u00c2\u00bf (h1 y h5), ssbps y los d\u00edmeros h2a\/h2b. En este trabajo hemos visto que invitro np tambi\u00e9n interacciona con los d\u00edmeros y tetr\u00e1meros h3\/h4 y con el oct\u00e1mero dehistonas. Ensayos de inmunoprecipitaci\u00f3n en extractos de oocito y huevo demuestran laexistencia de complejos entre np y h3\/h4. A relaciones molares np:h3\/h4subestequiom\u00e9tricas, la chaperona une d\u00edmeros h3\/h4. Cuando el complejo se satura(np:h3\/h4 1:2), se obtiene un complejo similar al formado con el oct\u00e1mero de histonas,en el que dos pent\u00e1meros de np unen y estabilizan por su cara distal dos tetr\u00e1merosh3\/h4 o un oct\u00e1mero de histonas, a diferencia de los complejos np:h2a\/h2b quecontienen hasta cinco d\u00edmeros de histona por pent\u00e1mero de np. La hiperfosforilaci\u00f3n dela chaperona incrementa su afinidad por los distintos tipos de histonas y ligeras diferenciasde afinidad entre ellos (kdapp h1\u00c2\u00bfh5<h2a\/h2b\n\n<h3\/h4) permiten a la chaperona llevara cabo su actividad remodeladora de cromatina.\n\n\n\n&nbsp;\n\n\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de los complejos nucleoplasmina: histona y su papel en el remodelado de la cromatina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de los complejos nucleoplasmina: histona y su papel en el remodelado de la cromatina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Noelia Fernandez Rivero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/04\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adelina Prado Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Rodriguez arrondo <\/li>\n<li>adrian Velazquez campoy (vocal)<\/li>\n<li>nuria Saperas plana (vocal)<\/li>\n<li>oscar Llorca blanco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Noelia Fernandez Rivero La nucleoplasmina (np o npm2) es una chaperona de histonas presente en losoocitos (onp) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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