{"id":115526,"date":"2014-11-04T00:00:00","date_gmt":"2014-11-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-aceites-de-almendras-dulces-y-de-crisalida-del-gusano-de-la-seda-sobre-el-fotoenvejecimiento-cutaneo-inducido-en-ratones-skh1-crl-por-radiacion-uv\/"},"modified":"2014-11-04T00:00:00","modified_gmt":"2014-11-04T00:00:00","slug":"efecto-de-los-aceites-de-almendras-dulces-y-de-crisalida-del-gusano-de-la-seda-sobre-el-fotoenvejecimiento-cutaneo-inducido-en-ratones-skh1-crl-por-radiacion-uv","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/dermatologia\/efecto-de-los-aceites-de-almendras-dulces-y-de-crisalida-del-gusano-de-la-seda-sobre-el-fotoenvejecimiento-cutaneo-inducido-en-ratones-skh1-crl-por-radiacion-uv\/","title":{"rendered":"Efecto de los aceites de almendras dulces y de cris\u00e1lida del gusano de la seda sobre el fotoenvejecimiento cut\u00e1neo inducido en ratones skh1\/crl por radiaci\u00f3n uv"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Mar\u00eda Gil Ortega <\/strong><\/h2>\n<p>La piel es el \u00f3rgano m\u00e1s extenso del organismo y puede sufrir, adem\u00e1s del envejecimiento cronol\u00f3gico, el denominado fotoenvejecimiento o envejecimiento cut\u00e1neo patol\u00f3gico. Est\u00e1 caracterizado por un envejecimiento cut\u00e1neo m\u00e1s extenso y sobre todo, de mayor gravedad, pues engloba la fotocarcinog\u00e9nesis o presentaci\u00f3n de c\u00e1nceres cut\u00e1neos.  desde la antig\u00ed\u00bcedad, el hombre tuvo conciencia de la importancia del sol en su vida, pero tambi\u00e9n de sus efectos indeseables. En la actualidad las sociedades de los pa\u00edses desarrollados invierten sumas millonarias en la investigaci\u00f3n de sustancias que eviten o retrasen los efectos del envejecimiento, no s\u00f3lo por el culto a la belleza, sino por el gran coste econ\u00f3mico que tiene la asistencia sanitaria de las lesiones. En los \u00faltimos a\u00f1os, los aceites esenciales han recibido gran atenci\u00f3n dada su capacidad antioxidante, que podr\u00eda interferir en los mecanismos de fotoenvejecimiento, evitando la formaci\u00f3n de radicales libres y potenciando el subsistema inmunol\u00f3gico cut\u00e1neo.  por otro lado, a las dificultades metodol\u00f3gicas que supone la lenta evoluci\u00f3n de los tumores, se suman las limitaciones \u00e9ticas del desarrollo de modelos experimentales en humanos. Por esta raz\u00f3n, el primero de los objetivos de nuestro trabajo fue el establecimiento de un modelo de fotoenvejecimiento cut\u00e1neo en ratones skh-1, mediante la exposici\u00f3n cr\u00f3nica a radiaci\u00f3n ultravioleta (ruv), para en el segundo objetivo de nuestro estudio, evaluar las propiedades de dos aceites, el de almendras dulces y el de la cris\u00e1lida del gusano de la seda, como posibles fotoprotectores.   para la realizaci\u00f3n del estudio, utilizamos 60 ratones skh1\/crl, que se sometieron a radiaci\u00f3n ultravioleta, 60 minutos por sesi\u00f3n, tres veces por semana, durante un total de 80 sesiones, con 1.688 j\/cm2 de energ\u00eda total absorbida por cada animal. Los ratones se dividieron en tres grupos. El primero (control) s\u00f3lo recibi\u00f3 ruv y los otros dos fueron tratados t\u00f3picamente, previamente a la irradiaci\u00f3n, con aceite de almendras dulces (grupo ii) y con aceite de la cris\u00e1lida del gusano de seda (grupo iii).  todos los animales expuestos a las ruv presentaron las alteraciones caracter\u00edsticas del fotoenvejecimiento y fotocarcinog\u00e9nesis cut\u00e1nea, por lo que consideramos este modelo experimental id\u00f3neo para el estudio de esta patolog\u00eda, ya que la exposici\u00f3n cr\u00f3nica a las radiaciones provoc\u00f3 todo el espectro de lesiones propias del fotoenvejecimiento, si la exposici\u00f3n era prolongada (entre 65 y 80 sesiones), adem\u00e1s de tratarse de un modelo f\u00e1cilmente reproducible y de bajo coste.  no obstante, en nuestro estudio observamos diferencias significativas entre los animales tratados con el aceite de la cris\u00e1lida del gusano de seda (grupo iii) respecto a los de los otros dos grupos. En los ratones del grupo iii se observa un retraso en la presentaci\u00f3n de las lesiones cut\u00e1neas (6-9 semanas), con respecto a los otros grupos y hubo dos animales sin lesiones tumorales al final del experimento. Adem\u00e1s, el \u00e1rea media de las lesiones era menor en el grupo iii un 59,14% respecto al grupo control (reducci\u00f3n del 40,86%); el grupo tratado con aceite de almendras dulces, tan s\u00f3lo redujo el \u00e1rea media en un 10%. Esto sugiere las propiedades fotoprotectoras del aceite de cris\u00e1lida del gusano de seda, probablemente debidas a la acci\u00f3n de la sericina que contiene, que es un potente antioxidante.  este retraso en la presentaci\u00f3n de lesiones neopl\u00e1sicas y su menor volumen fue confirmado por el estudio inmunohistoqu\u00edmico, respecto a la metaloproteinasa 9 (mmps-9) y los inhibidores timp.    the skin is the largest organ of the body and may, in addition to chronological aging, suffer some disease called photoaging. It is characterized by a large aging of the skin and above all, what is more dangerous, photocarcinogenesis or presentation of skin cancers .  since antiquity, men became aware of the importance of the sun in our life, but also of its undesirable effects. At present, a lot of companies of developed countries invest a large amount of money in researching, looking for substances that prevent or delay the effects of aging, not only for beauty, but also by the great economic cost of health care. In recent years, essential oils have received great attention due to its antioxidant capacity, which may interfere with the mechanisms of photoaging, preventing the formation of free radicals and boosting the skin &apos;s immune subsystem.  furthermore, to the methodological difficulties of the slow evolution of tumors, ethical constraints on development of experimental models in humans are added . Therefore, the first objective of our work was to establish a model of cutaneous photoaging in skh -1 mice by chronic exposure to ultraviolet radiation (uvr). The second objetive of our study was to evaluate the properties of two oils, sweet almond and chrysalis of silkworm, as possible photoprotective .  for the study, we used 60 mice skh1\/crl, that received ultraviolet radiation, 60 minutes per session, three times per week, for a total of 80 sessions , with 1,688 j\/cm2 of total energy absorbed by each animal. The mice were divided into three groups. The first (control) received only uvr and the other two were treated topically prior to irradiation, with sweet almond oil (group ii ) and oil of silkworm chrysalis (group iii).  all animals exposed to uvr showed the characteristic alterations of cutaneous photoaging and photocarcinogenesis, so consider this experimental model as ideal for the study of this disease, since chronic exposure to radiation caused the entire spectrum of lesions characteristic of photoaging, if the exposure was prolonged (65 to 80 sessions), besides being an easily reproducible and not expensive model .  however, in our study we observed significant differences between animals treated with oil of chrysalis silkworm (group iii) compared to the other two groups. In group iii, mice observed a delay in the presentation of skin lesions (6-9 weeks), with respect to the other groups, and there were three animals without tumor lesions at the end of the experiment. In addition, the mean area of lesions was lower in group iii (59.14 %) than in the control group (40.86 % reduction), the group treated with sweet almond oil only reduced the area by 10 %. This suggests the photoprotective properties of oil of silkworm chrysalis, probably due to the action containing sericin, which is a potent antioxidant.  this delay in the presentation of neoplastic lesions and their smaller area was confirmed by immunohistochemical study, regarding metalloproteinase 9 ( mmp -9) and timp inhibitors.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de los aceites de almendras dulces y de cris\u00e1lida del gusano de la seda sobre el fotoenvejecimiento cut\u00e1neo inducido en ratones skh1\/crl por radiaci\u00f3n uv<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de los aceites de almendras dulces y de cris\u00e1lida del gusano de la seda sobre el fotoenvejecimiento cut\u00e1neo inducido en ratones skh1\/crl por radiaci\u00f3n uv <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Mar\u00eda Gil Ortega <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/04\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Jos\u00e9 G\u00f3mez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Canteras jordana <\/li>\n<li>xavier Ca\u00f1as perea (vocal)<\/li>\n<li>Jos\u00e9 Luis Cenis anadon (vocal)<\/li>\n<li>Jos\u00e9 Manuel R\u00f3denas l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Mar\u00eda Gil Ortega La piel es el \u00f3rgano m\u00e1s extenso del organismo y puede sufrir, adem\u00e1s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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