{"id":115663,"date":"2018-03-11T10:44:21","date_gmt":"2018-03-11T10:44:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-sistemas-antigenicos-hla-y-mica-en-la-supervivencia-y-el-rechazo-de-injertos-hepaticos\/"},"modified":"2018-03-11T10:44:21","modified_gmt":"2018-03-11T10:44:21","slug":"papel-de-los-sistemas-antigenicos-hla-y-mica-en-la-supervivencia-y-el-rechazo-de-injertos-hepaticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/complutense-de-madrid\/papel-de-los-sistemas-antigenicos-hla-y-mica-en-la-supervivencia-y-el-rechazo-de-injertos-hepaticos\/","title":{"rendered":"Papel de los sistemas antig\u00e9nicos hla y mica en la supervivencia y el rechazo de injertos hep\u00e1ticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marcela Castillo Rama <\/strong><\/h2>\n<p>Los sistemas antig\u00e9nicos hla y mica pertenecen al complejo principal de histocompatibilidad cuyos genes se localizan en el brazo corto del cromosoma 6. Las mol\u00e9culas hla participan en la presentaci\u00f3n de ant\u00edgenos extra\u00f1os a linfocitos, mientras que los ant\u00edgenos mica son ligandos de c\u00e9lulas nk. Se ha observado que las mol\u00e9culas de ambos sistemas pueden servir como diana antig\u00e9nica en el rechazo de un \u00f3rgano trasplantado. la hip\u00f3tesis que se plantea es que, debido a su alto polimorfismo, los sistemas antig\u00e9nicos hla y mica y la alorespuesta humoral frente a ellos, contribuyen de forma desfavorable en la evoluci\u00f3n del injerto hep\u00e1tico, reduciendo la supervivencia post-trasplante e incrementando el riesgo de rechazo del aloinjerto. se realiz\u00f3 un estudio retrospectivo en el que se analizaron un total de 896 trasplantes hep\u00e1ticos de los cuales 782 fueron trasplantes primarios y 114 retrasplantes. Para determinar los ant\u00edgenos hla en receptores y donantes hep\u00e1ticos se utilizaron t\u00e9cnicas serol\u00f3gicas en el caso de hla clase i  y t\u00e9cnicas de gen\u00e9tica molecular en el caso de ant\u00edgenos hla de clase ii. El genotipaje de ant\u00edgenos mica se realiz\u00f3 por la t\u00e9cnica luminex de tipificaci\u00f3n inversa de adn de sso (labtype sso). La presencia de anticuerpos preformados anti-hla se detect\u00f3 por dos t\u00e9cnicas, citotoxicidad mediada por complemento y por citometr\u00eda multiparam\u00e9trica luminex. en conclusi\u00f3n, el resultado principal obtenido en esta tesis doctoral es que la presencia de anticuerpos preformados anti-hla juega un papel significativo en la supervivencia del aloinjerto hep\u00e1tico y el rechazo, mientras que la presencia anticuerpos anti-mica no parece jugar un papel relevante en la evoluci\u00f3n del aloinjerto hep\u00e1tico. Por tanto, la determinaci\u00f3n de anticuerpos anti-hla pre-trasplante, bien por prueba cruzada por cdc o por citometr\u00eda multiparam\u00e9trica, podr\u00eda ayudar a estratificar los pacientes con riesgo de forma anticipada y permitir una vigilancia m\u00e1s estrecha de los mismos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los sistemas antig\u00e9nicos hla y mica en la supervivencia y el rechazo de injertos hep\u00e1ticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los sistemas antig\u00e9nicos hla y mica en la supervivencia y el rechazo de injertos hep\u00e1ticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marcela Castillo Rama <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Estela Paz Artal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 ramon Regueiro  gonzalez barros <\/li>\n<li>Antonio Serrano hern\u00e1ndez (vocal)<\/li>\n<li>valentin Cuervas mons (vocal)<\/li>\n<li>melchor Alvarez de mon soto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marcela Castillo Rama Los sistemas antig\u00e9nicos hla y mica pertenecen al complejo principal de histocompatibilidad cuyos genes 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