{"id":115667,"date":"2018-03-11T10:44:21","date_gmt":"2018-03-11T10:44:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/electrophysiological-characterization-of-the-noradrenergic-and-serotonergic-systems-in-the-wistar-kyoto-rat-an-animal-model-of-depression\/"},"modified":"2018-03-11T10:44:21","modified_gmt":"2018-03-11T10:44:21","slug":"electrophysiological-characterization-of-the-noradrenergic-and-serotonergic-systems-in-the-wistar-kyoto-rat-an-animal-model-of-depression","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacos-psicotropicos\/electrophysiological-characterization-of-the-noradrenergic-and-serotonergic-systems-in-the-wistar-kyoto-rat-an-animal-model-of-depression\/","title":{"rendered":"Electrophysiological characterization of the noradrenergic and serotonergic systems in the wistar kyoto rat, an animal model of depression"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Bruzos Cidon <\/strong><\/h2>\n<p>La depresi\u00f3n es un trastorno afectivo que deshabilita al enfermo. Se encuentra establecido quelos f\u00e1rmacos antidepresivos que incrementan los niveles monoamin\u00e9rgicos mejoran lasintomatolog\u00eda de la depresi\u00f3n, pero menos del 50% de los pacientes responden de formapositiva al tratamiento. Tanto el locus coeruleus (lc) como el n\u00facleo dorsal del rafe (ndr)est\u00e1n implicados en funciones relacionadas con la sintomatolog\u00eda de la depresi\u00f3n. Por otrolado, se han observado alteraciones a nivel de los sistemas de regulaci\u00f3n glutamat\u00e9rgico ygaba\u00e9rgico. El receptor serotonergico 5-ht7 tambi\u00e9n ha tomado mayor importancia en eltratamiento de la depresi\u00f3n, ya que su antagonismo se traduce en una respuesta m\u00e1s tempranadel efecto antidepresivo. La rata wistar kyoto (wky) se considera un modelo animal dedepresi\u00f3n. Nuestra hip\u00f3tesis es que las transmisiones noradren\u00e9rgica y seroton\u00e9rgica est\u00e1nalteradas en las ratas wky. El objetivo general fue caracterizar las propiedadeselectrofisiol\u00f3gicas de las neuronas noradren\u00e9rgicas del lc y de las neuronas del ndr en lasratas wky con el objetivo observar diferencias con respecto a ratas control. Para ello, seutilizaron t\u00e9cnicas electrofisiol\u00f3gicas in vivo e in vitro. Este trabajo amplia el conocimientosobre la neurofisiolog\u00eda de las ratas wky, mostrando diferencias importantes a nivel de laactividad basal in vivo del lc y del ndr, y en las respuestas electrofisiol\u00f3gicas inducidas porlos antidepresivos reboxetina y fluoxetina. Adem\u00e1s, los estudios realizados con t\u00e9cnicaselectrofisiol\u00f3gicas in vitro muestran que los mecanismos intr\u00ednsecos y extr\u00ednsecos deregulaci\u00f3n inhibitoria de las neuronas del lc en ratas wky est\u00e1n reducidos. Finalmente, esteestudio demuestra que el as19 estimula las neuronas del lc con mayor eficacia en las rataswky y que su efecto es indirecto, probablemente localizado en \u00e1reas de proyecci\u00f3n al lc, yadem\u00e1s parece que la transmisi\u00f3n glutamat\u00e9rgica est\u00e1 implicada. Este estudio apoya el uso dela rata wky como un modelo animal \u00fatil para la caracterizaci\u00f3n de las bases neurobiol\u00f3gicasde patolog\u00edas relacionadas con una trasmisi\u00f3n monoamin\u00e9rgica disfuncional, como ladepresi\u00f3n, as\u00ed como para evaluar los efectos a nivel celular de diferentes f\u00e1rmacosantidepresivos en estas condiciones patol\u00f3gicas. Es m\u00e1s, tambi\u00e9n contribuye al conocimientode la funcionalidad de los receptores 5-ht7 y ampl\u00eda la caracterizaci\u00f3n de la rata wky comomodelo animal de depresi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Electrophysiological characterization of the noradrenergic and serotonergic systems in the wistar kyoto rat, an animal model of depression<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Electrophysiological characterization of the noradrenergic and serotonergic systems in the wistar kyoto rat, an animal model of depression <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Bruzos Cidon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/05\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Torrecilla Sesma<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Artigas p\u00e9rez <\/li>\n<li>yolanda Mateo gonzalez (vocal)<\/li>\n<li>pedro rolando Grandes moreno (vocal)<\/li>\n<li>Mar\u00eda  Javier Ramirez gil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Bruzos Cidon La depresi\u00f3n es un trastorno afectivo que deshabilita al enfermo. Se encuentra establecido quelos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[183,12909],"tags":[228704,137197,18274,182533,141058,173451],"class_list":["post-115667","post","type-post","status-publish","format-standard","hentry","category-farmacos-psicotropicos","category-pais-vasco-euskal-herriko-unibertsitatea","tag-cristina-bruzos-cidon","tag-francisco-artigas-perez","tag-maria-javier-ramirez-gil","tag-maria-torrecilla-sesma","tag-pedro-rolando-grandes-moreno","tag-yolanda-mateo-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/115667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=115667"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/115667\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=115667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=115667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=115667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}