{"id":11583,"date":"2018-03-09T08:57:01","date_gmt":"2018-03-09T08:57:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/respuesta-a-la-terapia-antirretroviral-triple-en-pacientes-vihpretratados\/"},"modified":"2018-03-09T08:57:01","modified_gmt":"2018-03-09T08:57:01","slug":"respuesta-a-la-terapia-antirretroviral-triple-en-pacientes-vihpretratados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/respuesta-a-la-terapia-antirretroviral-triple-en-pacientes-vihpretratados\/","title":{"rendered":"Respuesta a la terapia antirretroviral triple en pacientes vih+pretratados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Coro Perez Aznar <\/strong><\/h2>\n<p>Objetivos  valorar la respuesta virol\u00f3gica, inmunol\u00f3gica y cl\u00ednica al tratamiento antirretroviral (tarv) triple: un inhibidor de proteasa (ip) + dos inhibidores de trasncriptasa (it), en pacientes previamente tratados con dos it.  m\u00e9todos  68 pacientes con infecci\u00f3n por vih (49 hombres y 19 mujeres; edad media 37,4 + &#8211; 10 a\u00f1os) que segu\u00edan tratamiento previo con dos it fueron estudiados entre 1996 y 2000. A todos ellos, de forma abierta, se les a\u00f1adi\u00f3 como tercer f\u00e1rmaco un ip: saquinavir (sqv) = 23, ritonavir (rtv) = 22, indinavir (idv) = 23.  determinaciones  a los 0,3, 6,9 y 12 meses de tarv triple se valor\u00f3 la evoluci\u00f3n cl\u00ednica, toxicidad y adherencia al tratamiento; adem\u00e1s se determin\u00f3 en todos los pacientes carga viral plasm\u00e1tica (cv) de vih y recuento de linfocitos cd4 + cd8+ e inmunoglobulinas (igg, iga igm) y bsm s\u00e9ricas.  an\u00e1lisis estad\u00edstico  mediante el programa rsigma (por anova 1 repet. Para muestras pareadas y newman-keuls), se compararon las medidas de cada una de las variables determinadas a os 0,6, 6, 9 y 12 meses de tratamiento triple.  resultados  el m\u00e1ximo porcentaje de pacientes con carga viral indetectable (&lt;500 cp\/ml) fue de 46% (31\/68) a los 3 meses (seg\u00fan \u00abintenci\u00f3n de tratar\u00bb) y al final de los 12 meses de tarv triple era del 32% (22\/68). En la siguiente tabla figuran las medidas +-d.T. De las determinaciones trimestrales de carga viral (cv) y linfocitos cd4+.  meses tt.       0              3             6             9             12  n\u00c2\u00ba pacientes    68             68            67            53            44  cv log        4,63 +- 0,96   3,32+-1,29    3,47+-1,34    3,24+-1,32  2,94+-1,08  cd4 c\u00e9l\/ul    312+-273       411+-293      430+-331      501+-372   565+-397  en el conjunto de la muestra se aprecia un descenso mantenido (&gt;1 log) y altamente significativo (p&lt;0,001) de la carga viral media; por el contrario, se aprecia un significativo (p&lt;0,001) y progr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Respuesta a la terapia antirretroviral triple en pacientes vih+pretratados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Respuesta a la terapia antirretroviral triple en pacientes vih+pretratados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Coro Perez Aznar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Antonio P\u00e9rez De Oteyza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Enr\u00edquez de salamanca <\/li>\n<li>ramon Perez maeztu (vocal)<\/li>\n<li>julio De la morena fern\u00e1ndez (vocal)<\/li>\n<li> Fernandez guerrero Manuel Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Coro Perez Aznar Objetivos valorar la respuesta virol\u00f3gica, inmunol\u00f3gica y cl\u00ednica al tratamiento antirretroviral (tarv) triple: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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