{"id":116099,"date":"2018-03-11T10:44:58","date_gmt":"2018-03-11T10:44:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reacciones-adversas-a-medicamentos-en-neonatologia\/"},"modified":"2018-03-11T10:44:58","modified_gmt":"2018-03-11T10:44:58","slug":"reacciones-adversas-a-medicamentos-en-neonatologia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-de-farmacos\/reacciones-adversas-a-medicamentos-en-neonatologia\/","title":{"rendered":"Reacciones adversas a medicamentos en neonatolog\u00eda"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Belen Rivas Paterna <\/strong><\/h2>\n<p>En neonatolog\u00eda tiene lugar un extenso uso de medicamentos pero no se conocen bien sus caracter\u00edsticas ni sus efectos. metodolog\u00eda  estudio descriptivo prospectivo que se llevaba  a cabo a trav\u00e9s de un programa de monitorizaci\u00f3n intensiva en neonatos hospitalizados. Se recogi\u00f3 informaci\u00f3n sobre el paciente, el tratamiento farmacol\u00f3gico y las reacciones adversas identificadas por medio de protocolos estructurados, revisi\u00f3n de historias cl\u00ednicas y entrevistas directas a los padres del paciente y al profesional sanitario. el objetivo fue cuantificar y caracterizar las reacciones adversas y la prescripci\u00f3n de medicamentos fuera de ficha t\u00e9cnica y analizar la influencia de estos factores sobre la duraci\u00f3n de la estancia.  resultados, se incluyeron un total de 313 reci\u00e9n nacidos  y se analizaron un total de 2166 prescripciones.  se identificaron un total de 116 reacciones adversas ocurridas en 52 pacientes. El citrato de cafe\u00edna fue el principio activo que con mayor frecuencia origin\u00f3 reacci\u00f3n adversa y los antibi\u00f3ticos, como grupo, los m\u00e1s frecuentemente involucrados. de las prescripciones analizadas el 36 por ciento se realizaron de acuerdo a su ficha t\u00e9cnica. al analizar los factores de riesgo para la producci\u00f3n de reacciones adversas, observamos que el riesgo aumenta conforme lo hace el n\u00famero de prescripciones fuera de ficha t\u00e9cnica que se realizan al paciente. las reacciones adversas y las prescripciones fuera de ficha t\u00e9cnica parecen tener influencia sobre la duraci\u00f3n de la estancia hospitalaria, aunque esta relaci\u00f3n desaparece cuando se analiza de manera conjunta todas las variables que podr\u00edan influir sobre ella. Para confirmar su relaci\u00f3n ser\u00edan necesarios estudios de mayor tama\u00f1o muestral. en l\u00edneas generales, los resultados obtenidos en nuestro an\u00e1lisis est\u00e1n en concordancia con las escasas publicaciones existentes al respecto, las diferencias detectadas eran esperadas por la variaci\u00f3n en las caracter\u00edsticas de los pacientes, sistema de evaluaci\u00f3n utilizado y farmacoterapias. conclusiones, las reacciones adversas a medicamentos y la prescripci\u00f3n de f\u00e1rmacos fuera de ficha t\u00e9cnica poseen alta incidencia en neonatolog\u00eda y parecen influir en la duraci\u00f3n de la estancia hospitalaria. El uso de medicamentos fuera de ficha t\u00e9cnica es un factor de riesgo para la aparici\u00f3n de reacciones adversas. background  the importance for public health of the safe use of medicines, the vulnerability of the neonatal patient and the lack of pharmacovigilance are reasons for conducting this study.  the principal aim of this study is to quantify the frequency and describe the characteristics of adverse reactions and off-label use of drugs in a neonatal care unit. methodology  descriptive and prospective study of drug utilization through intensive pharmacology surveillance. The study population includes children hospitalized in the neonatal intensive care unit and in the neonatal medium care unit. We recorded information related with patient, drugs and adverse drugs reactions. results 313 neontates were included and 2166 drugs prescriptions were analyzed. 52 neonates developed at least one adverse drug reaction incidence rate igual a  38 por cie  after comparing the prescriptions made with the technical specifications we conclude that 36  were used in an authorized manner.  we saw there was a relationship between the off-label use and the adverse drug reaction debut. the incidence of adverse drug reactions and off-label drugs found in this study is consistent with what is expected based on published literature. The incidence rate of adverse drug reactions and off label drugs are greatly influenced by the definitions used, the method of detection and the study setting. This makes comparison of reported rates between studies extremely difficult. conclusion  adverse drug reactions and off-label drug use have a high incidence rate in children admitted to neonatal services and often lead to increased disease burden in this type of patient.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reacciones adversas a medicamentos en neonatolog\u00eda<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reacciones adversas a medicamentos en neonatolog\u00eda <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Belen Rivas Paterna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Arruza Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  vicente Beneit montesinos <\/li>\n<li>Antonio Gomez outes (vocal)<\/li>\n<li>alfonso Meneses monroy (vocal)<\/li>\n<li>Miguel Puerro vicente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Belen Rivas Paterna En neonatolog\u00eda tiene lugar un extenso uso de medicamentos pero no se conocen 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