{"id":11614,"date":"2018-03-09T08:57:04","date_gmt":"2018-03-09T08:57:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-sobre-la-participacion-de-la-nadph-oxidasa-en-la-arteriopatia-de-la-aorta-de-la-rata-espontaneamente-hipertensa\/"},"modified":"2018-03-09T08:57:04","modified_gmt":"2018-03-09T08:57:04","slug":"estudios-sobre-la-participacion-de-la-nadph-oxidasa-en-la-arteriopatia-de-la-aorta-de-la-rata-espontaneamente-hipertensa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudios-sobre-la-participacion-de-la-nadph-oxidasa-en-la-arteriopatia-de-la-aorta-de-la-rata-espontaneamente-hipertensa\/","title":{"rendered":"Estudios sobre la participacion de la nad(p)h oxidasa en la arteriopatia de la aorta de la rata espontaneamente hipertensa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Beaumont Ezcurra <\/strong><\/h2>\n<p>El presente estudio se ha realizado para demostrar la hip\u00f3tesis de que la estimulaci\u00f3n de la nad(p) h oxidasa esta implicada en el aumento de producci\u00f3n de ani\u00f3n super\u00f3xido (o2) vascular en las ratas espontaneamente hipertensas (shr). Este trabajo se realiz\u00f3 en ratas normotensas wistar-kioto de 16 y 30 semanas de edad (wky 16 y wky30, respectivamente) y en shr de 16 y 30 semanas de edad (shr16 y shr30, respectivamente). Adem\u00e1s, un grupo de ratas shr de 16 semanas fueron tratadas con irbesartan administrado oralmente (20 mg\/kg por dia) durante 14 semanas (shr30-i). La actividad nad(p) h oxidasa de la aorta se determin\u00f3 mediante un protocolo quimiluminiscente. la expresi\u00f3n del arn mensajero (arnm) se calculo mediante rt-pcr competitiva. la respuesta vascular a la acetilcolina se analiz\u00f3 por estudios isom\u00e9tricos de tensi\u00f3n. La estructura de la pared de la aorta se determin\u00f3 analizando el grosor de la media (gm) y el area de secci\u00f3n de corte (asc) mediante analisis morfom\u00e9tricos. La presi\u00f3n arterial sist\u00f3lica (pas) se encontraba significativamente aumentada en los dos grupos de animales hipertensos respecto a sus controles normotensos, y sin embargo no se observaron diferencias en cuanto a la pas entre shr30 y shr16. En las shr30, se observ\u00f3 un aumento en los niveles de arnm de la p22phox, en la produccion de o2 dependiente dela nad(p)h oxidasa y una expresi\u00f3n de la p22phox similar a la de las wky30. Los parametros funcionales y estructurales se encontraban corregidos en shr30-i presentaban una actividad nad(p) h oxidasa y una expresi\u00f3n de la p22phox similar a las de las wky30. Los parametros funcionales y estructurales se encontraban corregidos en shr30-i. Estos resultados sugieren que existe una asociaci\u00f3n entre la sobreexpresi\u00f3n del gen p22phox y la hiperactividad nad(p)h oxidasa en la aorta de las shr adultas. El aumento en la produccion de o2 dependiente de la nad(p)h oxidasa puede contribuir a la disfuncion endotelia<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios sobre la participacion de la nad(p)h oxidasa en la arteriopatia de la aorta de la rata espontaneamente hipertensa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios sobre la participacion de la nad(p)h oxidasa en la arteriopatia de la aorta de la rata espontaneamente hipertensa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Beaumont Ezcurra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Zalba Go\u00f1i<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: edurne Cenarruzabeitia sagarminaga <\/li>\n<li>Jos\u00e9 Antonio Paramo fernandez (vocal)<\/li>\n<li>vicente Lahera julia (vocal)<\/li>\n<li>ignacio Jos\u00e9 Encio Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Beaumont Ezcurra El presente estudio se ha realizado para demostrar la hip\u00f3tesis de que la 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