{"id":116155,"date":"2018-03-11T10:45:07","date_gmt":"2018-03-11T10:45:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-de-la-capacidad-genotoxica-de-farmacos-antihipertensivos-antagonistas-de-los-receptores-de-la-angiotensina-ii\/"},"modified":"2018-03-11T10:45:07","modified_gmt":"2018-03-11T10:45:07","slug":"evaluacion-de-la-capacidad-genotoxica-de-farmacos-antihipertensivos-antagonistas-de-los-receptores-de-la-angiotensina-ii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica-humana\/evaluacion-de-la-capacidad-genotoxica-de-farmacos-antihipertensivos-antagonistas-de-los-receptores-de-la-angiotensina-ii\/","title":{"rendered":"Evaluaci\u00f3n de la capacidad genot\u00f3xica de f\u00e1rmacos antihipertensivos antagonistas de los receptores de la angiotensina ii"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Iratxe Huerta Bengoa <\/strong><\/h2>\n<p>La hipertensi\u00f3n arterial, estado patol\u00f3gico definido como la elevaci\u00f3n persistente de lapresi\u00f3n arterial, es considerada uno de los principales problemas de salud p\u00fablica; supreValencia se sit\u00faa en el 40 % de la poblaci\u00f3n adulta. El tratamiento de la patolog\u00eda serealiza preferentemente con f\u00e1rmacos antihipertensivos. Los pacientes se encuentransometidos a una exposici\u00f3n larga e ininterrumpida a estos f\u00e1rmacos.Los f\u00e1rmacos antihipertensivos se clasifican en funci\u00f3n del mecanismo de acci\u00f3n porel que logran su efecto. Una de las clases son los antagonistas de los receptores deangiotensina ii (arb). Los arb son la \u00faltima clase terape\u00fatica incluida en la terapiaantihipertensiva.Estudios previos del equipo realizados en humanos han demostrado la capacidadgenot\u00f3xica in vivo e in vitro de dos clases de antihipertensivos, un \u00edY-bloqueante y uncalcio-antagonista. En esta investigaci\u00f3n, se ha evaluado la posible capacidadgenot\u00f3xica in vivo e in vitro, de cinco tipos de f\u00e1rmacos arb (candesart\u00e1n, valsart\u00e1n,eprosart\u00e1n, telmisart\u00e1n y olmesart\u00e1n) mediante la combinaci\u00f3n de ensayoscitogen\u00e9ticos y moleculares: ensayo de anomal\u00edas cromos\u00f3micas (ca) e identificaci\u00f3nde sitios fr\u00e1giles (fs), ensayo de micron\u00facleos (mn) e hibridaci\u00f3n in situ fluorescente(fish) y ensayo del cometa (scge). El an\u00e1lisis se ha realizado en linfocitos de sangreperif\u00e9rica (pbl) de 55 pacientes bajo tratamiento antihipertensivo y 10 individuoscontrol.Los resultados obtenidos sugieren una posible actividad genot\u00f3xica de los arbprincipalmente in vitro y, evidencian una asociaci\u00f3n entre el tratamientoantihipertensivo y un incremento en el nivel de da\u00f1o basal del dna.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluaci\u00f3n de la capacidad genot\u00f3xica de f\u00e1rmacos antihipertensivos antagonistas de los receptores de la angiotensina ii<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluaci\u00f3n de la capacidad genot\u00f3xica de f\u00e1rmacos antihipertensivos antagonistas de los receptores de la angiotensina ii <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Iratxe Huerta Bengoa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Arrieta S\u00e1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luisa Ugedo urruela <\/li>\n<li>blanca Laffon lage (vocal)<\/li>\n<li>amadeu Creus capdevila (vocal)<\/li>\n<li>Mar\u00eda  bego\u00f1a Criado alonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Iratxe Huerta Bengoa La hipertensi\u00f3n arterial, estado patol\u00f3gico definido como la elevaci\u00f3n persistente de lapresi\u00f3n arterial, es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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