{"id":116158,"date":"2018-03-11T10:45:07","date_gmt":"2018-03-11T10:45:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-activacion-biologica-de-los-implantes-regeneracion-osea-mediante-plasma-rico-en-factores-de-crecimiento\/"},"modified":"2018-03-11T10:45:07","modified_gmt":"2018-03-11T10:45:07","slug":"la-activacion-biologica-de-los-implantes-regeneracion-osea-mediante-plasma-rico-en-factores-de-crecimiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/tecnologia-de-materiales\/la-activacion-biologica-de-los-implantes-regeneracion-osea-mediante-plasma-rico-en-factores-de-crecimiento\/","title":{"rendered":"La activaci\u00f3n biol\u00f3gica de los implantes. regeneraci\u00f3n \u00f3sea mediante plasma rico en factores de crecimiento"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Tejero Cantero <\/strong><\/h2>\n<p>La integraci\u00c2\u00bfn \u00c2\u00bfsea de un implante se produce cuando se logra la uni\u00c2\u00bfn directa,duradera y funcional entre el hueso y la superficie del implante. Debido a la necesidadde acortar los tiempos de tratamiento y de acometer reconstrucciones cada vez m\u00c2\u00bfscomplejas, los dise\u00c2\u00bfos superficiales de los implantes est\u00c2\u00bfn siendo objeto de evoluci\u00c2\u00bfnconstante. Con el fin de estimular la actividad regenerativa desde la superficie de losimplantes, algunas de estas estrategias -denominadas biomim\u00c2\u00bfticas- se basan en lamodificaci\u00c2\u00bfn de las superficies con elementos de la matriz extracelular. En este trabajose ha evaluado tanto in vitro como in vivo los efectos de la modificaci\u00c2\u00bfn biomim\u00c2\u00bftica delas superficies de los implantes con plasma aut\u00c2\u00bflogo rico en plaquetas y factores decrecimiento bajo una formulaci\u00c2\u00bfn concreta denominada prgf (plasma rico en factoresde crecimiento). El prgf es una tecnolog\u00c2\u00bfa dise\u00c2\u00bfada para la administraci\u00c2\u00bfn de factoresde crecimiento plaquetarios y plasm\u00c2\u00bfticos end\u00c2\u00bfgenos en el lugar de la lesi\u00c2\u00bfn. En primerlugar, se ha demostrado que el prgf es un inductor de la regeneraci\u00c2\u00bfn \u00c2\u00bfsea a trav\u00c2\u00bfs dela estimulaci\u00c2\u00bfn de las c\u00c2\u00bflulas osteog\u00c2\u00bfnicas. Seguidamente, el estudio de la morfolog\u00c2\u00bfa,la composici\u00c2\u00bfn y la cin\u00c2\u00bftica de liberaci\u00c2\u00bfn de los se\u00c2\u00bfalizadores desde superficies deimplantes modificadas con prgf nos ha permitido evaluar la importancia de laactivaci\u00c2\u00bfn plaquetaria y de la fibrina en la configuraci\u00c2\u00bfn de la matriz provisional y en laevoluci\u00c2\u00bfn de la interfase implante-hueso. Este conocimiento ha llevado al dise\u00c2\u00bfo de unanueva superficie de implante modificada con calcio cuyos efectos sin\u00c2\u00bfrgicos encombinaci\u00c2\u00bfn con el prgf han sido validados en modelos de osteointegraci\u00c2\u00bfn in vivo,mediante el aumento de la osteointegraci\u00c2\u00bfn y la reducci\u00c2\u00bfn de los tiempos de curaci\u00c2\u00bf<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La activaci\u00f3n biol\u00f3gica de los implantes. regeneraci\u00f3n \u00f3sea mediante plasma rico en factores de crecimiento<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La activaci\u00f3n biol\u00f3gica de los implantes. regeneraci\u00f3n \u00f3sea mediante plasma rico en factores de crecimiento <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Tejero Cantero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gorka Orive Arroyo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felix Mar\u00eda Go\u00f1i urcelay <\/li>\n<li>Mar\u00eda Luisa Gonz\u00e1lez mart\u00edn (vocal)<\/li>\n<li>felipe Luis Prosper cardoso (vocal)<\/li>\n<li>M\u00aa lorenza Escudero rinc\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Tejero Cantero La integraci\u00c2\u00bfn \u00c2\u00bfsea de un implante se produce cuando se logra la uni\u00c2\u00bfn directa,duradera [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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