{"id":116194,"date":"2018-03-11T10:45:07","date_gmt":"2018-03-11T10:45:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-celulas-madre-tumorales-de-cancer-de-mama-desarrollo-de-nuevos-farmacos\/"},"modified":"2018-03-11T10:45:07","modified_gmt":"2018-03-11T10:45:07","slug":"caracterizacion-de-celulas-madre-tumorales-de-cancer-de-mama-desarrollo-de-nuevos-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/citologia\/caracterizacion-de-celulas-madre-tumorales-de-cancer-de-mama-desarrollo-de-nuevos-farmacos\/","title":{"rendered":"Caracterizaci\u00f3n de c\u00e9lulas madre tumorales de c\u00e1ncer de mama. desarrollo de nuevos f\u00e1rmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Gumucio Barrie <\/strong><\/h2>\n<p>Las opciones terap\u00e9uticas actuales en c\u00e1ncer de mama son limitadas, el cambio de paradigma que supone el descubrimiento de c\u00e9lulas madre tumorales necesariamente implica un profundo replanteamiento del abordaje actual utilizado en el tratamiento del c\u00e1ncer de mama. Atacando directamente a las c\u00e9lulas que generan y mantienen el tumor, estos acabar\u00e1n desapareciendo. Para dise\u00f1ar nuevas terapias dirigidas a acabar con esta poblaci\u00f3n de c\u00e9lulas es necesario ampliar el conocimiento de los mecanismos espec\u00edficos que controlan su biolog\u00eda. Para ello identificamos y aislamos c\u00e9lulas madre tumorales de c\u00e1ncer de mama mediante el cultivo en suspensi\u00f3n de mamoesferas de tumores primarios de pacientes. Posteriormente analizamos el perfil de expresi\u00f3n g\u00e9nica de las mamoesferas mediante microarrays, para detectar funciones biol\u00f3gicas alteradas en las esferas de tumor y definir mecanismos reguladores propios de las c\u00e9lulas madre tumorales que permitan identificar nuevas dianas terap\u00e9uticas espec\u00edficas. A partir de estos resultados se realiz\u00f3 un cribado de f\u00e1rmacos frente a c\u00e9lulas madre tumorales mediante ensayos funcionales in vitro (ensayo de formaci\u00f3n de esferas mamoesferas, an\u00e1lisis de marcadores) e in vivo (xenotransplante en ratones inmunodeprimidos y pez cebra). En paralelo se estudi\u00f3 el papel de los fibroblastos asociados a tumor y las c\u00e9lulas madre tumorales mediante cultivo con medios condicionadas, an\u00e1lisis de marcadores moleculares y ensayos funcionales, observando que el cultivo con medio condicionado de fibroblastos de tumor aumenta el porcentaje de c\u00e9lulas positivas para marcadores de c\u00e9lulas madre tumorales. Los resultados obtenidos muestran que las c\u00e9lulas madre tumorales presentan una serie de mecanismos reguladores de los procesos biol\u00f3gicos alterados y que es posible dirigir nuevas terapias contra ellos que permitan su eliminaci\u00f3n espec\u00edfica, contribuyendo a la mejora en el tratamiento del c\u00e1ncer de mama.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de c\u00e9lulas madre tumorales de c\u00e1ncer de mama. desarrollo de nuevos f\u00e1rmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de c\u00e9lulas madre tumorales de c\u00e1ncer de mama. desarrollo de nuevos f\u00e1rmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Gumucio Barrie <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Garcia Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Miguel Ar\u00e9chaga mart\u00ednez <\/li>\n<li>isidro Javier S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<li>Javierabel Men\u00e9ndez men\u00e9ndez (vocal)<\/li>\n<li>i\u00f1igo Zubiaurre Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Gumucio Barrie Las opciones terap\u00e9uticas actuales en c\u00e1ncer de mama son limitadas, el cambio de paradigma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2727,848,9399,12909],"tags":[159209,229498,40871,43573,229497,13203],"class_list":["post-116194","post","type-post","status-publish","format-standard","hentry","category-anticuerpos","category-citologia","category-cultivo-celular","category-pais-vasco-euskal-herriko-unibertsitatea","tag-angel-garcia-martin","tag-inigo-zubiaurre-Martinez","tag-isidro-javier-sanchez-garcia","tag-javierabel-menendez-menendez","tag-juan-gumucio-barrie","tag-juan-miguel-arechaga-Martinez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=116194"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116194\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=116194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=116194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=116194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}