{"id":116250,"date":"2014-04-09T00:00:00","date_gmt":"2014-04-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-tlr4-en-neurorreparacion-tras-ictus-isquemico-experimental\/"},"modified":"2014-04-09T00:00:00","modified_gmt":"2014-04-09T00:00:00","slug":"implicacion-de-tlr4-en-neurorreparacion-tras-ictus-isquemico-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/implicacion-de-tlr4-en-neurorreparacion-tras-ictus-isquemico-experimental\/","title":{"rendered":"Implicaci\u00f3n de tlr4 en neurorreparaci\u00f3n tras ictus isqu\u00e9mico experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Moraga Yebenes <\/strong><\/h2>\n<p>El ictus isqu\u00e9mico es la segunda causa de muerte y discapacidad en todo el mundo. Pero, pese a sus consecuencias devastadoras, actualmente la \u00fanica terapia efectiva aprobada es la recanalizaci\u00f3n del vaso ocluido por medio de la administraci\u00f3n intravenosa de rt-pa (activador del plasmin\u00f3geno tisular recombinante) para la fase aguda del ictus, s\u00f3lo accesible para el 5 por ciento de los pacientes. Por lo que se hace imprescindible el desarrollo de nuevas terapias neuroprotectoras y neurorreparadoras para combatir la enfermedad. el sistema inmune, promoviendo la respuesta inflamatoria, participa en el da\u00f1o cerebral producido por la isquemia. De hecho, se ha demostrado la implicaci\u00f3n del receptor tlr4, un receptor con un papel fundamental en la activaci\u00f3n del sistema inmune, en el da\u00f1o cerebral agudo.  nuestro objetivo fue determinar el papel de tlr4 sobre la neurog\u00e9nesis en condiciones patol\u00f3gicas, estudiando la proliferaci\u00f3n, migraci\u00f3n y diferenciaci\u00f3n tras ictus isqu\u00e9mico, y la influencia de la edad en este proceso, ya que es el principal factor de riesgo para sufrir un ictus.  los ensayos se llevaron a cabo ocluyendo de forma permanente la arteria cerebral media (mcao) en ratones deficientes para tlr4 y otros que lo expresaban de forma normal. Nuestros resultados indican que, ante el mismo tama\u00f1o de infarto, la deficiencia de tlr4 aumenta la proliferaci\u00f3n celular en la zona subventricular (zsv), retrasa la migraci\u00f3n de neuroblastos e incrementa el n\u00famero de nuevas interneuronas corticales tras producirse la isquemia. Tambi\u00e9n se vio que la edad, sin variar el tama\u00f1o de la lesi\u00f3n, aumenta la proliferaci\u00f3n microglial en la corteza peri-infarto y la infiltraci\u00f3n de neutr\u00f3filos. Y no s\u00f3lo inhibe la proliferaci\u00f3n celular en la zsv sino que tambi\u00e9n bloquea la migraci\u00f3n de neuroblastos al \u00e1rea da\u00f1ada y reduce el n\u00famero de nuevas interneuronas. en resumen, nuestros resultados indican que tlr4 posee un doble papel en el ictus, mediando el da\u00f1o cerebral en la fase aguda y promoviendo neurog\u00e9nesis en la fase cr\u00f3nica, mientras que la edad puede tener efectos delet\u00e9reos en ambas fases del ictus, alterando la progresi\u00f3n del da\u00f1o cerebral y retrasando o disminuyendo la neurog\u00e9nesis. Estos resultados ponen de manifiesto la importancia de usar animales viejos para los estudios de translaci\u00f3n a la cl\u00ednica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de tlr4 en neurorreparaci\u00f3n tras ictus isqu\u00e9mico experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de tlr4 en neurorreparaci\u00f3n tras ictus isqu\u00e9mico experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Moraga Yebenes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/09\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Lizasoain Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel Colado megia <\/li>\n<li>Jos\u00e9 Vivancos mora (vocal)<\/li>\n<li>Manuel Fresno escudero (vocal)<\/li>\n<li>lisardo Bosc\u00e1 gomar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Moraga Yebenes El ictus isqu\u00e9mico es la segunda causa de muerte y discapacidad en todo el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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