{"id":116295,"date":"2014-12-09T00:00:00","date_gmt":"2014-12-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-en-red-del-transcriptoma-y-su-regulacion-en-la-esclerosis-multiple\/"},"modified":"2014-12-09T00:00:00","modified_gmt":"2014-12-09T00:00:00","slug":"estudio-en-red-del-transcriptoma-y-su-regulacion-en-la-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica-humana\/estudio-en-red-del-transcriptoma-y-su-regulacion-en-la-esclerosis-multiple\/","title":{"rendered":"Estudio en red del transcriptoma y su regulaci\u00f3n en la esclerosis m\u00faltiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aritz Irizar Aguirre <\/strong><\/h2>\n<p>La complejidad de la esclerosis m\u00faltiple a varios niveles invita a acudir a campos como la teor\u00eda de sistemas complejos que aportan herramientas que nos permiten abordar el entendimiento de esa complejidad. Uno de los niveles en los que esa complejidad se manifiesta es la etiolog\u00eda y, como ya se hab\u00eda observado en otros trabajos, nuestros resultados indican que los factores de riesgo relacionados con la enfermedad interact\u00faan de manera compleja. Hemos observado que el principal elemento gen\u00e9tico de riesgo, el alelo hla-drb1*15:01, confiere riesgo s\u00f3lo en mujeres y que ese riesgo est\u00e1 modulado por variantes del gen vdr. La construcci\u00f3n de una red de coexpresi\u00f3n nos ha permitido observar, a partir de datos de expresi\u00f3n g\u00e9nica en sangre, que los mecanismos moleculares asociados a la din\u00e1mica brote \u00c2\u00bf remisi\u00f3n de la enfermedad son diferentes para mujeres y varones y sugiere para las primeras un modelo patofisiol\u00f3gico en el que la preactivaci\u00f3n de los neutr\u00f3filos es un mecanismo end\u00f3geno de control de la reactivaci\u00f3n del virus ebv. Adem\u00e1s, la construcci\u00f3n de redes de coexpresi\u00f3n sncrna \u00c2\u00bf mrna ha revelado que la enfermedad tiene un fuerte impacto en la organizaci\u00f3n de estas redes y ha arrojado una lista de candidatos para una hipot\u00e9tica intervenci\u00f3n terap\u00e9utica basada en la manipulaci\u00f3n de los sncrna. Los dos principales problemas con los que nos hemos encontrado en el desarrollo de esta tesis son por una parte la heterogeneidad a nivel cl\u00ednico, molecular y celular que presenta la enfermedad y, por otra, la urgente necesidad de organizar la gran cantidad de informaci\u00f3n que se ha recopilado sobre la etiolog\u00eda de la enfermedad. Estos problemas podr\u00edan abordarse con la construcci\u00f3n de un mapa etiol\u00f3gico de la enfermedad describiendo las interacciones entre los factores de riesgo e introduciendo la informaci\u00f3n etiol\u00f3gica en la definici\u00f3n de subtipos de la enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio en red del transcriptoma y su regulaci\u00f3n en la esclerosis m\u00faltiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio en red del transcriptoma y su regulaci\u00f3n en la esclerosis m\u00faltiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aritz Irizar Aguirre <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/09\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adolfo L\u00f3pez De Muniain Arregui<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Larra\u00f1aga mugica <\/li>\n<li>fuencisla Matesanz del barrio (vocal)<\/li>\n<li>Jos\u00e9 ramon Bilbao catala (vocal)<\/li>\n<li>Elena Urcelay Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aritz Irizar Aguirre La complejidad de la esclerosis m\u00faltiple a varios niveles invita a acudir a campos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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