{"id":116306,"date":"2018-03-11T10:45:18","date_gmt":"2018-03-11T10:45:18","guid":{"rendered":""},"modified":"2018-03-11T10:45:18","modified_gmt":"2018-03-11T10:45:18","slug":"effects-of-two-phenolic-compounds-resveratrol-and-pterostilbene-on-fat-accumulation-and-related-co-morbilities-efectos-de-dos-compuestos-fenolicos-resveratrol-y-pteroestilbeno-sobre-la-acumulacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-nutricion\/effects-of-two-phenolic-compounds-resveratrol-and-pterostilbene-on-fat-accumulation-and-related-co-morbilities-efectos-de-dos-compuestos-fenolicos-resveratrol-y-pteroestilbeno-sobre-la-acumulacion\/","title":{"rendered":"Effects of two phenolic compounds, resveratrol and pterostilbene, on fat accumulation and related co-morbilities\/efectos de dos compuestos fen\u00f3licos, resveratrol y pteroestilbeno, sobre la acumulaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Saioa Gomez Zorita <\/strong><\/h2>\n<p>La obesidad, definida como una excesiva acumulaci\u00f3n de grasa corporal, se asocia a unestado cr\u00f3nico de inflamaci\u00f3n que incrementa el riesgo de padecer co-morbilidadescomo la resistencia a la insulina y el h\u00edgado graso. El hecho de que se est\u00e9 convirtiendoen una pandemia mundial, ha llevado a la comunidad cient\u00edfica a la b\u00fasqueda deingredientes presentes en la dieta que puedan resultar \u00fatiles para disminuir esa excesivaacumulaci\u00f3n de grasa corporal. Entre los posibles candidatos se encuentrancompuestos fen\u00f3licos como el resveratrol y el pteroestilbeno.El tratamiento de ratas zucker (fa\/fa) obesas con resveratrol redujo el peso de losdep\u00f3sitos adiposos viscerales, directamente relacionados con las co-morbilidadesasociadas a la obesidad, debido a una menor captaci\u00f3n de \u00e1cidos grasos y a unincremento de la lip\u00f3lisis. En consecuencia, se observ\u00f3 la disminuci\u00f3n de lainflamaci\u00f3n asociada. As\u00ed mismo, el resveratrol atenu\u00f3 la esteatosis hep\u00e1tica alincrementar la oxidaci\u00f3n de l\u00edpidos, y contribuy\u00f3 a un menor estr\u00e9s oxidativo en elh\u00edgado.Por otra parte, en un modelo animal de obesidad inducida por la dieta, el pteroestilbenoigualmente disminuy\u00f3 la acumulaci\u00f3n de grasa corporal debido, al menos en parte, aun descenso de la lipog\u00e9nesis en el tejido adiposo. Adem\u00e1s, bajo nuestras condicionesexperimentales, el pteroestilbeno mejor\u00f3 el control gluc\u00e9mico al incrementar lacaptaci\u00f3n de glucosa mediada por los transportadores glut4 en m\u00fasculo esquel\u00e9tico,y al incrementar la glucolisis hep\u00e1tica.Finalmente, se llev\u00f3 a cabo un experimento en adipocitos humanos en los que seobserv\u00f3 que el resveratrol aument\u00f3 la lip\u00f3lisis estimulada por un agente betaadren\u00e9rgico,la isoprenalina, e inhibi\u00f3 parcialmente el efecto anti-lipol\u00edtico ylipog\u00e9nico de la insulina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Effects of two phenolic compounds, resveratrol and pterostilbene, on fat accumulation and related co-morbilities\/efectos de dos compuestos fen\u00f3licos, resveratrol y pteroestilbeno, sobre la acumulaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Effects of two phenolic compounds, resveratrol and pterostilbene, on fat accumulation and related co-morbilities\/efectos de dos compuestos fen\u00f3licos, resveratrol y pteroestilbeno, sobre la acumulaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Saioa Gomez Zorita <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/09\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Del Puy Portillo Baquedano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 alfredo Martinez hernandez <\/li>\n<li>carmen patricia P\u00e9rez matute (vocal)<\/li>\n<li>benedicte f\u00e1tima P\u00e9rez de heredia (vocal)<\/li>\n<li>enrique Echevarria orella (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Saioa Gomez Zorita La obesidad, definida como una excesiva acumulaci\u00f3n de grasa corporal, se asocia a unestado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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