{"id":116338,"date":"2018-03-11T10:45:24","date_gmt":"2018-03-11T10:45:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/gib-2f5-epitopoaren-aurkako-erantzun-immune-humoralak-eragiteko-estrategiak\/"},"modified":"2018-03-11T10:45:24","modified_gmt":"2018-03-11T10:45:24","slug":"gib-2f5-epitopoaren-aurkako-erantzun-immune-humoralak-eragiteko-estrategiak","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/gib-2f5-epitopoaren-aurkako-erantzun-immune-humoralak-eragiteko-estrategiak\/","title":{"rendered":"Gib-2f5 epitopoaren aurkako erantzun immune humoralak eragiteko estrategiak"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aitziber Araujo Pasarin <\/strong><\/h2>\n<p>Laburpena: gib-1 birusa zabalki neutralizatzen duten antigorputzen isolamenduak, erantzun immune eraginkorra garatzeko ahalmen potentziala egiaztatu du. Birusaren andui desberdinetan kontserbatutako mper domeinua ezagutzen du mab2f5 antigorputz neutralizatzaileak. 2f5 epitopoa sekuentzia lineala gisa deskribatu egin zen arren, dagoeneko, mper-peptidoetan oinarritutako txertoek ez dute mab2f5-bezalako antigorputz neutralizatzailerik sorrarazi. Tesi honetan, mper eratorri ezberdinen immunogenizitatea aztertu egin da.Alde batetik, mperaz gain, fusio-peptidoak ere epitopoaren konformazio antigenikoaren egonkorketan parte hartzen duela proposatu egin da. Beraz, mper\/fp konplexuen eraketa eta immunogenizitatea aztertu egin dira, baita mintz lipidikoaren eragina ere. Lortutako datuek, mperaren kontrako erantzun neutralizatzailea lortzeko, bai fp sekuentzia, bai mintza, ezinbestekoak direla aditzera ematen dute.Bestetik, hainbat ezaugarri batzen dituen mperp izeneko peptidoa erabili egin da laguntzaile desberdinen efektua aztertzeko: alumina, \u00c2\u00bffreund\u00c2\u00bf laguntzailea eta liposomak\/a-lipidoa. Laguntzaile hauek erabiliz eragindako antigorputzek, mab2f5-aren zenbait ezaugarri batzen bazuten ere, ez zuten aktibitate neutralizatzailerik erakutsi.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Gib-2f5 epitopoaren aurkako erantzun immune humoralak eragiteko estrategiak<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Gib-2f5 epitopoaren aurkako erantzun immune humoralak eragiteko estrategiak <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aitziber Araujo Pasarin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Nieva Escad\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mercedes Renobales scheifler <\/li>\n<li>Rafael Aldabe arregui (vocal)<\/li>\n<li>felix Elortza basterrika (vocal)<\/li>\n<li>ismael Mingarro mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aitziber Araujo Pasarin Laburpena: gib-1 birusa zabalki neutralizatzen duten antigorputzen isolamenduak, erantzun immune eraginkorra garatzeko ahalmen potentziala [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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