{"id":116360,"date":"2018-03-11T10:45:24","date_gmt":"2018-03-11T10:45:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/impact-of-prenatal-organochlorine-compounds-on-early-neuropsychological-development\/"},"modified":"2018-03-11T10:45:24","modified_gmt":"2018-03-11T10:45:24","slug":"impact-of-prenatal-organochlorine-compounds-on-early-neuropsychological-development","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salud-publica\/impact-of-prenatal-organochlorine-compounds-on-early-neuropsychological-development\/","title":{"rendered":"Impact of prenatal organochlorine compounds on early neuropsychological development"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aritz Aranbarri Paredes <\/strong><\/h2>\n<p>El hexaclorobenceno (hcb), el dicloro-difenil-dicloro-etileno (p,p\u00c2\u00bfdde) y los bifenilos policlorados (pcbs) son compuestos organoclorados (ocs) caracterizados por su persistencia y bioacumulaci\u00f3n y por ser contaminantes ambientales t\u00f3xicos con efectos potencialmente neurot\u00f3xicos para el desarrollo neuropsicol\u00f3gico temprano. El objetivo fue evaluar el nivel prenatal de ocs, y su asociaci\u00f3n con el desarrollo neuropsicol\u00f3gico temprano. M\u00e9todo: nuestra muestra estuvo constituida por una cohorte de nacimiento de base poblacional, derivada del proyecto inma (infancia y medio ambiente), reclutada entre 2006 y 2008, en el hospital de zum\u00e1rraga. Los principales an\u00e1lisis se llevaron a cabo utilizando 401 diadas madre-hijo\/a de las que se pose\u00eda informaci\u00f3n completa sobre niveles prenatales de ocs (obtenidos tanto del suero materno durante el embarazo como del suero de cord\u00f3n umbilical del neonato) y  sobre desarrollo neuropsicol\u00f3gico a los 26 meses (evaluado mediante las escalas bayley de desarrollo infantil). Se utilizaron modelos multivariados de regresi\u00f3n lineal y se introdujeron en los modelos los predictores principales del desarrollo neuropsicol\u00f3gico, as\u00ed como las potenciales variables confusoras, incluyendo la calidad del contexto socio-familiar. Resultados: los niveles de los tres ocs estudiados muestran que, tanto los obtenidos de suero materno como de suero de cord\u00f3n umbilical del neonato, est\u00e1n relacionados con una p\u00e9rdida de puntuaci\u00f3n sub-cl\u00ednica del desarrollo motor. Se observ\u00f3 una disminuci\u00f3n media de 7 puntos en la escala motora de bayley (con una p\u00e9rdida de entre 5 y 9 puntos), por cada incremento de 10 unidades en los niveles prenatales de ocs. No se hallaron efectos sobre el desarrollo cognitivo. Conclusi\u00f3n: estos resultados sugieren la existencia de un efecto potencialmente neurot\u00f3xico de los ocs que puede evidenciarse incluso en una cohorte de ni\u00f1os con base poblacional y expuesta a niveles bajos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Impact of prenatal organochlorine compounds on early neuropsychological development<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Impact of prenatal organochlorine compounds on early neuropsychological development <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aritz Aranbarri Paredes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/09\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Fano Ardanaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gabriela Chotro <\/li>\n<li>jordi Sunyer deu (vocal)<\/li>\n<li>natalia Ojeda del pozo (vocal)<\/li>\n<li>joan Forns guzman (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aritz Aranbarri Paredes El hexaclorobenceno (hcb), el dicloro-difenil-dicloro-etileno (p,p\u00c2\u00bfdde) y los bifenilos policlorados (pcbs) son compuestos organoclorados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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