{"id":116410,"date":"2014-01-10T00:00:00","date_gmt":"2014-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-lingo-1-rs9652490-y-rs11856808-y-riesgo-para-el-desarrollo-de-esclerosis-multiple\/"},"modified":"2014-01-10T00:00:00","modified_gmt":"2014-01-10T00:00:00","slug":"polimorfismos-lingo-1-rs9652490-y-rs11856808-y-riesgo-para-el-desarrollo-de-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurologia\/polimorfismos-lingo-1-rs9652490-y-rs11856808-y-riesgo-para-el-desarrollo-de-esclerosis-multiple\/","title":{"rendered":"Polimorfismos lingo-1 rs9652490 y rs11856808 y riesgo para el desarrollo de esclerosis m\u00faltiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda D\u00edaz S\u00e1nchez <\/strong><\/h2>\n<p>Introducci\u00f3n  la prote\u00edna lingo1 es una glicoprote\u00edna transmembrana implicada en fen\u00f3menos inhibitorios tanto sobre la maduraci\u00f3n de los oligodendrocitos y la formaci\u00f3n de mielina, como sobre la supervivencia neuronal y la regeneraci\u00f3n axonal. Estudios recientes han sugerido su probable implicaci\u00f3n en la patogenia de la esclerosis m\u00faltiple (em). En este contexto, y en un intento por identificar marcadores gen\u00e9ticos de susceptibilidad para el desarrollo de em, decidimos estudiar dos polimorfismos de un solo nucle\u00f3tido (snp) comunes del gen lingo1 (rs9652490 y rs11856808), que se hab\u00edan asociado con otras enfermedades neurol\u00f3gicas. Pacientes y m\u00e9todo  en este estudio procedimos a analizar la frecuencia de los genotipos y las variantes al\u00e9licas de los snps lingo1 rs9652490 y lingo1 rs11856808 empleando la tecnolog\u00eda kaspar, en un total de 293 pacientes con em y 318 individuos sanos.Resultados  las frecuencias de los genotipos de lingo1 rs9652490 y lingo1 rs11856808, as\u00ed como de sus variantes al\u00e9licas, no difirieron significativamente entre los pacientes diagnosticados de em y los sujetos control. La frecuencia del alelo menor del snp lingo1 rs9652490 fue 0.171 y 0.167 en el grupo de pacientes con em y de voluntarios sanos respectivamente (p= 0.853). En el caso del snp lingo1 rs11856808, la frecuencia del alelo menor fue 0.317 y 0.310 en los casos y los controles respectivamente (p= 0.773). Tampoco detectamos diferencias al realizar este mismo an\u00e1lisis por subgrupos en funci\u00f3n del g\u00e9nero, la forma evolutiva de em ni la edad de comienzo de la enfermedad.Conclusi\u00f3n   los resultados de esta tesis sugieren que los genotipos y las variantes al\u00e9licas de lingo1 rs9652490 y lingo1 rs11856808 no presentan relaci\u00f3n con el riesgo de padecer em en la poblaci\u00f3n caucasiana espa\u00f1ola, y tampoco influyen en la edad de comienzo ni en la forma evolutiva de la misma<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos lingo-1 rs9652490 y rs11856808 y riesgo para el desarrollo de esclerosis m\u00faltiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos lingo-1 rs9652490 y rs11856808 y riesgo para el desarrollo de esclerosis m\u00faltiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda D\u00edaz S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>albea Ristol Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li>Mar\u00eda dolores Jim\u00e9nez hern\u00e1ndez (vocal)<\/li>\n<li>pedro Garc\u00eda ruiz-espiga (vocal)<\/li>\n<li>Mar\u00eda  trinidad Herrero ezquerro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda D\u00edaz S\u00e1nchez Introducci\u00f3n la prote\u00edna lingo1 es una glicoprote\u00edna transmembrana implicada en fen\u00f3menos inhibitorios tanto sobre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,11771,1880],"tags":[77194,229822,124703,17871,14431,76170],"class_list":["post-116410","post","type-post","status-publish","format-standard","hentry","category-alcala","category-genetica-clinica","category-neurologia","tag-albea-ristol-garcia","tag-maria-diaz-sanchez","tag-maria-dolores-jimenez-hernandez","tag-maria-trinidad-herrero-ezquerro","tag-melchor-alvarez-de-mon-soto","tag-pedro-garcia-ruiz-espiga"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=116410"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116410\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=116410"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=116410"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=116410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}