{"id":116501,"date":"2018-03-11T10:45:35","date_gmt":"2018-03-11T10:45:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-bosentan-sobre-la-funcion-vascular-e-inflamacion-de-pacientes-diabeticos-con-enfermedad-arterial-periferica\/"},"modified":"2018-03-11T10:45:35","modified_gmt":"2018-03-11T10:45:35","slug":"efecto-del-bosentan-sobre-la-funcion-vascular-e-inflamacion-de-pacientes-diabeticos-con-enfermedad-arterial-periferica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/complutense-de-madrid\/efecto-del-bosentan-sobre-la-funcion-vascular-e-inflamacion-de-pacientes-diabeticos-con-enfermedad-arterial-periferica\/","title":{"rendered":"Efecto del bosent\u00e1n sobre la funci\u00f3n vascular e inflamaci\u00f3n de pacientes diab\u00e9ticos con enfermedad arterial perif\u00e9rica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Martin Conejero <\/strong><\/h2>\n<p>Introducci\u00f3n. La endotelina-1 (et-1) es un vasoconstrictor end\u00f3geno que interviene en la regulaci\u00f3n del tono vasomotor y remodelado vascular. El bosent\u00e1n antagoniza el efecto de la et-1 mediante el bloqueo de los receptores de endotelina et-a y et-b. objetivo. Analizar el nivel de expresi\u00f3n de et-1, de metabolitos del \u00f3xido n\u00edtrico (no) y de marcadores proinflamatorios (interleucina-6, il-6) y antiinflamatorios (interleucina-10, il-10), en pacientes diab\u00e9ticos con arteriopat\u00eda perif\u00e9rica, claudicantes y con lesiones tr\u00f3ficas, y en controles no diab\u00e9ticos. pacientes. Grupo-1 (g1) grupo de controles no diab\u00e9ticos (n igual a 10) apareados por edad y sexo con grupos de pacientes diab\u00e9ticos, grupo-2 (g2) grupo de pacientes diab\u00e9ticos con claudicaci\u00f3n (n igual a 10), grupo-3 (g3) grupo de pacientes diab\u00e9ticos con lesiones tr\u00f3ficas (n igual a 10). metodolog\u00eda. Niveles de expresi\u00f3n plasm\u00e1tica de et-1 (dot-blot), de concentraciones plasm\u00e1ticas de il-6 e il-10 (kits de elisa). En c\u00e9lulas mononucleares se determin\u00f3 la capacidad de liberar no (kit de nitratos m\u00e1s nitritos). resultados. Se observa un aumento de los niveles de et-1 (g1 172,9. G2 277,1. G3 367,3. P menor que 0.05, unidades arbitrarias) y un descenso de il-6 en las formas m\u00e1s avanzadas de la enfermedad (g145,8, g2 16,4. G3 9,8. P menor que 0.05, pg-ml). Bosent\u00e1n elev\u00f3 los niveles de il-6 en el grupo de lesiones tr\u00f3ficas hasta igualarla con el grupo control.  se observ\u00f3 una reducci\u00f3n significativa de la capacidad de liberar \u00f3xido n\u00edtrico por los leucocitos en el grupo de pacientes diab\u00e9ticos con lesiones tr\u00f3ficas (g1 16,7.G3 12, p nemor que 0.05, micromol-l). Este efecto se revirti\u00f3 significativamente en presencia de bosent\u00e1n. conclusiones. \tlos niveles elevados de et-1 podr\u00edan influir en el tono vasomotor de la arteriopat\u00eda diab\u00e9tica sobre todo en los estadios m\u00e1s avanzados de la enfermedad \ten la arteriopat\u00eda avanzada parece existir un descenso de la actividad inflamatoria (disminuci\u00f3n de il6), lo que podr\u00eda implica una menor capacidad de vasodilataci\u00f3n (reducci\u00f3n de no). \tbosent\u00e1n tiene un efecto antagonista tanto sobre la constricci\u00f3n a trav\u00e9s del descenso de et-1 y el aumento de no, fundamentalmente en los estadios m\u00e1s avanzados de la enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del bosent\u00e1n sobre la funci\u00f3n vascular e inflamaci\u00f3n de pacientes diab\u00e9ticos con enfermedad arterial perif\u00e9rica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del bosent\u00e1n sobre la funci\u00f3n vascular e inflamaci\u00f3n de pacientes diab\u00e9ticos con enfermedad arterial perif\u00e9rica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Martin Conejero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/10\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Mo\u00f1ux Ducaju<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Arias p\u00e9rez <\/li>\n<li>Jos\u00e9 ignacio Leal lorenzo (vocal)<\/li>\n<li>pilar caridad Morata barrado (vocal)<\/li>\n<li>sara Gonzalez sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Martin Conejero Introducci\u00f3n. La endotelina-1 (et-1) es un vasoconstrictor end\u00f3geno que interviene en la regulaci\u00f3n del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1550,986],"tags":[229953,86235,22643,229952,131696,226906],"class_list":["post-116501","post","type-post","status-publish","format-standard","hentry","category-cirugia-vascular","category-complutense-de-madrid","tag-antonio-martin-conejero","tag-guillermo-monux-ducaju","tag-jaime-arias-perez","tag-jose-ignacio-leal-lorenzo","tag-pilar-caridad-morata-barrado","tag-sara-gonzalez-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=116501"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116501\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=116501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=116501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=116501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}