{"id":116526,"date":"2018-03-11T10:45:40","date_gmt":"2018-03-11T10:45:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regioselective-synthesis-and-functionalization-of-2-and-3-aryl-benzobfurans-application-to-medicinal-chemistry\/"},"modified":"2018-03-11T10:45:40","modified_gmt":"2018-03-11T10:45:40","slug":"regioselective-synthesis-and-functionalization-of-2-and-3-aryl-benzobfurans-application-to-medicinal-chemistry","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-heterociclicos\/regioselective-synthesis-and-functionalization-of-2-and-3-aryl-benzobfurans-application-to-medicinal-chemistry\/","title":{"rendered":"Regioselective synthesis and functionalization of 2- and 3-aryl benzo(b)furans. application to medicinal chemistry"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leire Lidia Arias Echeverria <\/strong><\/h2>\n<p>En esta tesis se aborda el estudio de diversas reacciones dirigidas a la s\u00edntesis y posteriorfuncionalizaci\u00f3n de benzo[b]furanos parcialmente sustituidos, as\u00ed como la posible aplicaci\u00f3n en elcampo de la biomedicina de algunos de los compuestos preparados. Este resumen est\u00e1organizado siguiendo el esquema que se detalla a continuaci\u00f3n:introducci\u00f3nmemoriaresultados y discusi\u00f3n1. Preparaci\u00f3n regioselectiva de benzo[b]furanos 2- y 3-aril sustituidos (cap\u00edtulo 2)1.1. Estudio experimental1.2. Estudio computacional2. Transformaciones con 2- y 3-aril benzo[b]furanos (cap\u00edtulo 3)2.1. Halogenaci\u00f3n regioselectiva de benzo[b]furanos sustituidos mediada por nhalosuccinimidas2.2. Desaromatizaci\u00f3n oxidante de benzo[b]furanos monohidroxilados mediada porreactivos de iodo hipervalente2.3. Desmetilaci\u00f3n de grupos metoxilo presentes en benzo[b]furanos mediada portribromuro de boro3. Benzo[b]furanos como an\u00e1logos del resveratrol: ensayos biol\u00f3gicos (cap\u00edtulo 4)3.1. Ensayos enzim\u00e1ticos: modulaci\u00f3n de sirt13.1. Ensayos celulares: propiedades antitumoralesbibliograf\u00eda seleccionadamencionar tambi\u00e9n que en este resumen se mantiene la numeraci\u00f3n de los compuestos y de lasreferencias empleada en el manuscrito original.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regioselective synthesis and functionalization of 2- and 3-aryl benzo(b)furans. application to medicinal chemistry<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regioselective synthesis and functionalization of 2- and 3-aryl benzo(b)furans. application to medicinal chemistry <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leire Lidia Arias Echeverria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/10\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Iosu Ion Vara Salazar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Miguel Oyarbide garmendia <\/li>\n<li>laurent Pouys\u00e9gu (vocal)<\/li>\n<li>M\u00aa del pilar Prieto n\u00fa\u00f1ez-polo (vocal)<\/li>\n<li>Jes\u00fas Garcia castillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leire Lidia Arias Echeverria En esta tesis se aborda el estudio de diversas reacciones dirigidas a la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,53714,12909],"tags":[146754,201856,146756,214589,229990,229991],"class_list":["post-116526","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-hidruros","category-pais-vasco-euskal-herriko-unibertsitatea","tag-iosu-ion-vara-salazar","tag-jesus-garcia-castillo","tag-juan-miguel-oyarbide-garmendia","tag-laurent-pouysegu","tag-leire-lidia-arias-echeverria","tag-ma-del-pilar-prieto-nunez-polo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=116526"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116526\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=116526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=116526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=116526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}