{"id":116564,"date":"2018-03-11T10:45:46","date_gmt":"2018-03-11T10:45:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/resistina-y-obesidad\/"},"modified":"2018-03-11T10:45:46","modified_gmt":"2018-03-11T10:45:46","slug":"resistina-y-obesidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/resistina-y-obesidad\/","title":{"rendered":"Resistina y obesidad"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Parre\u00f1o Caparros <\/strong><\/h2>\n<p>Introducci\u00f3n y objetivo: la resistina, una nueva adipoquina perteneciente a la familia de las prote\u00ednas ricas en ciste\u00edna o relms (mol\u00e9culas similares a resistina), es tambi\u00e9n llamada fizz3 (encontrado en zona inflamatoria) o adsf (factor secretor espec\u00edfico de adipocito). Fue descubierta en 2001 por 3 grupos diferentes que realizaban investigaciones en modelos animales. El t\u00e9rmino de resistina se propuso inicialmente por su potencial papel como mediador de la resistencia a la insulina en la obesidad en roedores, siendo un nexo de uni\u00f3n entre ambos. Sin embargo, esos hallazgos no se han podido demostrar en humanos. Mientras que en roedores la resistina se expresa predominantemente en adipocitos, en humanos la resistina se expresa principalmente en las c\u00e9lulas inflamatorias. Nuestro objetivo fue estudiar si existen diferencias en los niveles de resistina entre pacientes con obesidad m\u00f3rbida y sujetos sanos con normopeso, y si los niveles de resistina en pacientes con obesidad m\u00f3rbida se modificaban tras una importante p\u00e9rdida de peso por cirug\u00eda bari\u00e1trica. Tambi\u00e9n se estudi\u00f3 la posible relaci\u00f3n de la resistina con par\u00e1metros metab\u00f3licos, inflamatorios y factores de riesgo vascular.  m\u00e9todo: se seleccionaron un total de 71 pacientes con obesidad m\u00f3rbida (\u00edndice de masa corporal (imc) ? 40 kg\/m2) y 31 sujetos sanos con normopeso (imc &lt; 25 kg\/m2). Las variables estudiadas en todos los casos fueron: par\u00e1metros antropom\u00e9tricos y de adiposidad (peso, talla, imc, masa grasa, \u00edndice cintura-cadera (icc)), niveles de presi\u00f3n arterial (tensi\u00f3n arterial sist\u00f3lica (tas), tensi\u00f3n arterial diast\u00f3lica (tad)), variables bioqu\u00edmicas (glucosa, hemoglobina glicosilada (hba1c), insulina, colesterol total (ct), lipoprote\u00ednas de alta densidad (hdl), triglic\u00e9ridos (tg), \u00e1cido \u00farico, microalbuminuria (mau), prote\u00edna c reactiva ultrasensible (hpcr)), citoquinas inflamatorias (interleucina-6 (il-6)), citoquinas antiinflamatorias (adiponectina) y resistina. Se calcularon homa (evaluaci\u00f3n del modelo homeost\u00e1tico), quicki (\u00edndice cuantitativo de sensibilidad a la insulina) y ldl (lipoprote\u00ednas de baja densidad). A los pacientes con obesidad se les realiz\u00f3 un bypass g\u00e1strico y, a los 12 meses de la cirug\u00eda tras una importante p\u00e9rdida de peso, se reevaluaron las mismas variables.  resultados: no encontramos diferencias significativas entre los niveles de resistina entre pacientes con obesidad m\u00f3rbida y sujetos sanos con normopeso, ni tampoco entre los pacientes con obesidad antes y despu\u00e9s de la p\u00e9rdida de peso. Los niveles de resistina, en los pacientes obesos m\u00f3rbidos, no se correlacionaron con las medidas antropom\u00e9tricas y de adiposidad, ni tampoco con los niveles de tas y tad, insulina, glucosa, homa, quicki, ct, hdl, tg, \u00e1cido \u00farico, hpcr, il-6 y adiponectina. Sin embargo, s\u00ed exist\u00eda una correlaci\u00f3n positiva entre resistina y hba1c (r = 0,270, p = 0,004), resistina y mau (r = 0,360, p = 0,019); y una correlaci\u00f3n negativa de la resistina con ldl (r = -0,297, p = 0,018). En el grupo de obesos, al a\u00f1o de la p\u00e9rdida de peso, la resistina se correlacion\u00f3 positivamente con tas (r = 0,310, p = 0,013), mau (r = 0,518, p = 0,0001) e il-6 (r = 0,291, p = 0,017). El resto de par\u00e1metros estudiados no mostraron correlaci\u00f3n alguna con los niveles de resistina.   mientras que los niveles de resistina en el subgrupo de pacientes con obesidad m\u00f3rbida y dm no difer\u00edan del resto, los niveles de resistina en el subgrupo de pacientes con obesidad m\u00f3rbida e hipertensi\u00f3n arterial (hta) eran significativamente superiores al resto de pacientes con obesidad.  conclusi\u00f3n: nuestros resultados no apoyan la relaci\u00f3n de la resistina con la obesidad, con la resistencia a la insulina ni con la inflamaci\u00f3n, y sugieren una posible relaci\u00f3n con la hta.   introduction and objective: resistin, a new adipokine belonging to the cysteine-rich proteins family known as relms, is also called fizz3 or adsf. It was discovered in 2001 by three different groups doing research in animal models. Resistin term was originally suggested as a potential mediator of obesity related insulin resistance in rodents. However, in humans, these findings have not been demonstrated yet. While rodent resistin is expressed predominantly in adipocytes, human resistin is mainly expressed in inflammatory cells. Our aim was to study whether there was differences in resistin levels in patients with morbid obesity and lean subjects, as well as analyzing changes in resistin levels in patients with morbid obesity after significant weight loss due to bariatric surgery. Possible associations of resistin with metabolic parameters, inflammatory parameters and vascular risk factors were also studied.  methods: a total of 71 patients with morbid obesity (body mass index (bmi) ? 40 kg\/m2) and 31 healthy subjects with normal weight (bmi &lt; 25 kg\/m2) were selected. The variables studied in all cases were: anthropometric and adiposity parameters (weight, height, bmi, fat mass, waist-hip ratio (whr)), blood pressure levels (systolic and diastolic blood pressure (sbp, dbp)) and bioquimic variables (glucose, hba1c, insulin, total colesterol (tc), hdl, tg, uric acid, mau, high-sensitivity c-reactive protein (hs-crp)), inflammatory cytokines (il-6), antiinflammatory cytokines (adiponectin) and resistin. Homa, quicki and ldl were calculated. Obese patients underwent a gastric surgery, and after 12 months and major weight loss, same variables were reassessed.  results: significant differences between resistin levels among morbid obesity patients and healthy subjects with normal weight had not found, nor between obese patients before and after weight loss. Resistin levels in morbid obesity patients had not had any correlation with adiposity anthropometric measures, nor with the sbp levels and dbp, insulin, glucose, homa, quicki, tc, hdl, tg, uric acid, hs-crp, il-6 and adiponectin. Nevertheless, a positive correlation had obtained between resistin and hba1c (r = 0.270, p = 0.004), resistin and mau (r = 0.360, p = 0.019), and a negative correlation between ldl and resistin (r = &#8211; 0.297, p = 0.018). In the morbid obesity group, after one year of weight loss, resistin had positively correlated with sbp (r = 0.310, p = 0.013), mau (r = 0.518, p = 0.0001) and il-6 (r = 0.291, p = 0.017). Other parameters under study showed no correlation with resistin levels.  while resistin levels in the subgroup of patients with obesity and diabetes had not differed from the rest, resistin levels in the subgroup of patients with obesity and hypertension had showed a significant higher rate than other obese patients.  conclusion: our results do not support the relationship of resistin with obesity, insulin resistance and inflammation, and suggest a possible relationship with hypertension.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Resistina y obesidad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Resistina y obesidad <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Parre\u00f1o Caparros <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/10\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fatima Illan Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Soriano palao <\/li>\n<li>Francisco Botella romero (vocal)<\/li>\n<li>agust\u00edn \u00e1ngel Merchante alfaro (vocal)<\/li>\n<li>elisa Martinez alfaro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Parre\u00f1o Caparros Introducci\u00f3n y objetivo: la resistina, una nueva adipoquina perteneciente a la familia de las 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