{"id":116603,"date":"2014-06-11T00:00:00","date_gmt":"2014-06-11T00:00:00","guid":{"rendered":""},"modified":"2014-06-11T00:00:00","modified_gmt":"2014-06-11T00:00:00","slug":"analisis-de-la-expresion-genica-global-en-estadios-iniciales-del-carcinoma-no-microca%c2%adtico-de-pulmon-identificacion-de-un-predictor-de-recidiva-asociado-con-las-celulas-b-del-sistema-inmune","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia\/analisis-de-la-expresion-genica-global-en-estadios-iniciales-del-carcinoma-no-microca%c2%adtico-de-pulmon-identificacion-de-un-predictor-de-recidiva-asociado-con-las-celulas-b-del-sistema-inmune\/","title":{"rendered":"An\u00e1lisis de la expresi\u00f3n g\u00e9nica global en estadios iniciales del carcinoma no microc\u00edtico de pulm\u00f3n. identificaci\u00f3n de un predictor de recidiva asociado con las c\u00e9lulas b del sistema inmune"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Hern\u00e1ndez Prieto <\/strong><\/h2>\n<p>En el estudio no se encontr\u00f3 asociaci\u00f3n estad\u00edsticamente significativa entre ninguna de las variables cl\u00ednico-histopatol\u00f3gicas estudiadas con el intervalo libre de enfermedad (ile). Solamente la presencia de mutaciones de k-ras mostr\u00f3 tendencia respecto al ile con una p=0.072.La clasificaci\u00f3n molecular no relacionada con los subtipos histol\u00f3gicos se llev\u00f3 a cabo utilizando los 84 tumores incluidos en el estudio y el listado de 2.160 genes y permiti\u00f3 diferenciar tres grupos moleculares o clusters (cluster 1, cluster 2 y cluster 3)     en lo referente a la distribuci\u00f3n de las muestras. La curva de kaplan-meier (km) mostr\u00f3 diferencias estad\u00edsticamente significativas respecto al ile (p=0.004) entre los tres clusters indicando una menor probabilidad de recidiva para el cluster 3 respecto del cluster 2         y cluster 1. Adem\u00e1s se encontr\u00f3 que existe asociaci\u00f3n estad\u00edsticamente significativa de estos tres clusters no relacionados con la histolog\u00eda y el h\u00e1bito tab\u00e1quico (p=0.002),           la afectaci\u00f3n ganglionar (p=0.041) y la inflamaci\u00f3n cr\u00f3nica (p=0.002). El cluster 1 es que el incluye el mayor n\u00famero de muestras tumorales provenientes de pacientes que fuman de manera activa en el momento del diagn\u00f3stico. Adem\u00e1s incluye los tres \u00fanicos tumores con afectaci\u00f3n ganglionar y un elevado n\u00famero de tumores caracterizados con inflamaci\u00f3n cr\u00f3nica baja o leve. El cluster 2 se caracteriza por incluir los cinco \u00fanicos pacientes<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la expresi\u00f3n g\u00e9nica global en estadios iniciales del carcinoma no microc\u00edtico de pulm\u00f3n. identificaci\u00f3n de un predictor de recidiva asociado con las c\u00e9lulas b del sistema inmune<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la expresi\u00f3n g\u00e9nica global en estadios iniciales del carcinoma no microc\u00edtico de pulm\u00f3n. identificaci\u00f3n de un predictor de recidiva asociado con las c\u00e9lulas b del sistema inmune <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Hern\u00e1ndez Prieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/11\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juli\u00e1n Sanz Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li>Jos\u00e9 Luis Subiza garrido-lestache (vocal)<\/li>\n<li>Carlos Simon adiego (vocal)<\/li>\n<li>Jos\u00e9 Luis Gonz\u00e1lez larriba (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Hern\u00e1ndez Prieto En el estudio no se encontr\u00f3 asociaci\u00f3n estad\u00edsticamente significativa entre ninguna de las variables [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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