{"id":11661,"date":"2018-03-09T08:57:08","date_gmt":"2018-03-09T08:57:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-antinociceptivo-de-la-asociacion-metamizol-tramadol-en-rata\/"},"modified":"2018-03-09T08:57:08","modified_gmt":"2018-03-09T08:57:08","slug":"efecto-antinociceptivo-de-la-asociacion-metamizol-tramadol-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-antinociceptivo-de-la-asociacion-metamizol-tramadol-en-rata\/","title":{"rendered":"Efecto antinociceptivo de la asociaci\u00f3n metamizol-tramadol en rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Poveda Martin <\/strong><\/h2>\n<p>Introducci\u00f3n  las combinaciones de analg\u00e9sicos son utilizadas en cl\u00ednica con el fin de mejorar la eficacia analg\u00e9sica y disminuir los efectos indeseables.  objetivos  evaluar la interacci\u00f3n entre metamizol (mtz) y tramadol (trm) combinados en diferentes proporciones, en un modelo de dolor visceral agudo en rata. la interacci\u00f3n resultante se analizar\u00e1 utilizando distintos m\u00e9todos (isobologramas, \u00edndices de interacci\u00f3n, m\u00e9todo de chou y chou, anova y t de student).  material y m\u00e9todos  el estudio fue realizado en rata macho sprague-dawle (130-150 g). El efecto antinociceptivo de mtz, trm y sus combinaciones fue evaluado en un modelo de contracci\u00f3n abdominal \u00abwrithing test\u00bb utilizando como irritante ac.Etacr\u00ednico (i.P.). Los f\u00e1rmacos y sus combinaciones fueron administrados s.C. 30 minutos antes que el irritante. Experimentos realizados:  a,- curvas dosis-respuestas (d-r) para cada f\u00e1rmaco solo y combinados en tres proporciones fijas en base a su potencia individual al 50% de efecto mtz:trm 1:1, 1:3 y 1: 0.3.  b,- d-r de mtz solo en presencia de una dosis fija de trm.  c,- estudio de la reversibilidad de los efectos inducidos por las de80 de mtz, trm y sus combinaciones tras la administraci\u00f3n s.C. De 1 mg\/kg de naloxona.  resultados y conclusiones  mtz, trm y sus combinaciones disminuyen el n\u00famero de contracciones abdominales de modo dosis-dependiente. El an\u00e1lisis de los resultados demostr\u00f3 que las tres combinaciones de mtz y trm en propociones fijas (1:1, 1:3 y 1:0.3) interaccionan de modo sin\u00e9rgico al 80% del efecto, pero s\u00f3lo la combinaci\u00f3n 1:1 es sin\u00e9rgica al 50%. Cuando mtz y trm se combinaron de forma que a la dosis-respuesta de mtz se le a\u00f1adi\u00f3 una dosis fija de trm, los resultados del anova y t de student mostraron sin\u00e9rgica a partir del 60% del efecto (p&lt;0,01). Naloxona revirti\u00f3 parcialmente la ed80 de trm (70%), pero no revirti\u00f3 la ed80 de mtz. La revisi\u00f3n de las combinaciones fue gradua<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto antinociceptivo de la asociaci\u00f3n metamizol-tramadol en rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto antinociceptivo de la asociaci\u00f3n metamizol-tramadol en rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Poveda Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M. Eulalia Planas  Domingo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: xavier Forn dalmau <\/li>\n<li>pablo Ortiz betes (vocal)<\/li>\n<li>Manuel Feria rodr\u00edguez (vocal)<\/li>\n<li>mag\u00ed Farr\u00e9 albaladejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Poveda Martin Introducci\u00f3n las combinaciones de analg\u00e9sicos son utilizadas en cl\u00ednica con el fin de mejorar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,9,2445,957,6530],"tags":[13850,13915,9924,25726,38280,29442],"class_list":["post-11661","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-farmacologia-experimental","tag-m-eulalia-planas-domingo","tag-magi-farre-albaladejo","tag-manuel-feria-rodriguez","tag-pablo-ortiz-betes","tag-raquel-poveda-martin","tag-xavier-forn-dalmau"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=11661"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/11661\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=11661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=11661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=11661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}