{"id":116618,"date":"2014-07-11T00:00:00","date_gmt":"2014-07-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-neuroprotector-del-cannabidiol-y-la-hipotermia-en-la-encefalopata%c2%ada-hipoxico-isquemica-neonatal\/"},"modified":"2014-07-11T00:00:00","modified_gmt":"2014-07-11T00:00:00","slug":"efecto-neuroprotector-del-cannabidiol-y-la-hipotermia-en-la-encefalopata%c2%ada-hipoxico-isquemica-neonatal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pediatria\/efecto-neuroprotector-del-cannabidiol-y-la-hipotermia-en-la-encefalopata%c2%ada-hipoxico-isquemica-neonatal\/","title":{"rendered":"Efecto neuroprotector del cannabidiol y la hipotermia en la encefalopat\u00edahip\u00f3xico-isqu\u00e9mica neonatal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hector Lafuente Echevarria <\/strong><\/h2>\n<p>La lesi\u00f3n cerebral hip\u00f3xico-isqu\u00e9mica representa una de las principales causas de mortalidad y morbilidad neurol\u00f3gica tanto en el reci\u00e9n nacido prematuro como en el reci\u00e9n nacido a t\u00e9rmino. Es un hecho notable que a pesar de la mejor\u00eda en la vigilancia fetal intraparto y la disminuci\u00f3n del trauma obst\u00e9trico, no se ha conseguido reducir la incidencia de par\u00e1lisis cerebral en los \u00faltimos 30 a\u00f1os. El aumento de partos prematuros y de gestaciones m\u00faltiples, as\u00ed como la mayor supervivencia de esos ni\u00f1os de alto riesgo, hacen que la preValencia de la lesi\u00f3n hip\u00f3xico-isqu\u00e9mica haya aumentado a nivel mundial. El principal objetivo de este trabajo de investigaci\u00f3n, es desarrollar un modelo experimental reproducible de encefalopat\u00eda hip\u00f3xico-isqu\u00e9mia neonatal en cerdos reci\u00e9n nacidos y demostrar la eficacia y seguridad del uso del cannabidiol como agente neuroprotector tanto a corto como a medio plazo, y su uso combinado con la hipotermia. Para demostrar la eficacia del tratamiento, se han determinado y comparado las alteraciones histol\u00f3gicas y celulares, los niveles de biomarcadores cerebrales y los estudios de funcionalidad. Adem\u00e1s, para comprobar la seguridad del tratamiento, se han determinar los efectos secundarios a nivel de los sistemas cardiovascular, hep\u00e1tico, pulmonar y renal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto neuroprotector del cannabidiol y la hipotermia en la encefalopat\u00edahip\u00f3xico-isqu\u00e9mica neonatal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto neuroprotector del cannabidiol y la hipotermia en la encefalopat\u00edahip\u00f3xico-isqu\u00e9mica neonatal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hector Lafuente Echevarria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/11\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonia De Los Angeles Alvarez Diaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Francisco Madrid cuevas <\/li>\n<li>inmaculada Guerricagoitia marina (vocal)<\/li>\n<li>Jos\u00e9 Antonio Martinez orgado (vocal)<\/li>\n<li>\u00c1lvaro D\u00edaz mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hector Lafuente Echevarria La lesi\u00f3n cerebral hip\u00f3xico-isqu\u00e9mica representa una de las principales causas de mortalidad y morbilidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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