{"id":116646,"date":"2018-03-11T10:45:52","date_gmt":"2018-03-11T10:45:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-acido-all-trans-retinoico-reduce-in-vitro-el-efecto-protumoral-de-los-factores-de-crecimiento-e-incrementa-la-eficacia-de-la-quimioterapia-en-el-rabdomiosarcoma-s4mh\/"},"modified":"2018-03-11T10:45:52","modified_gmt":"2018-03-11T10:45:52","slug":"el-acido-all-trans-retinoico-reduce-in-vitro-el-efecto-protumoral-de-los-factores-de-crecimiento-e-incrementa-la-eficacia-de-la-quimioterapia-en-el-rabdomiosarcoma-s4mh","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia\/el-acido-all-trans-retinoico-reduce-in-vitro-el-efecto-protumoral-de-los-factores-de-crecimiento-e-incrementa-la-eficacia-de-la-quimioterapia-en-el-rabdomiosarcoma-s4mh\/","title":{"rendered":"El \u00e1cido all trans retinoico reduce in vitro el efecto protumoral de los factores de crecimiento e incrementa la eficacia de la quimioterapia en el rabdomiosarcoma s4mh"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Roberto Sanisidro Torre <\/strong><\/h2>\n<p>El rabdomiosarcoma (rms) es el sarcoma de partes blandas infantil m\u00e1s frecuente, conun mal pron\u00f3stico y baja supervivencia libre de tumor cuando la enfermedad seencuentra en fase metast\u00e1tica. Una de las razones de dicha baja tasa de supervivencia esel desarrollo de resistencia al tratamiento antitumoral. Entre las posibles causas dequimiorresistencia se encuentra la presencia de factores de crecimiento (fc)en elmicroambiente tumoral. Los objetivos de este estudio son analizar: i, la implicaci\u00f3n delos fc (vegf, hgf, pdgf, igf-2, fgfb y egf) en la cin\u00e9tica proliferativa del rmsmurino metast\u00e1tico s4mh; ii, la influencia de dichos fc en la resistencia a laquimioterapia convencional (qc) con melfal\u00e1n, vincristina (vcr) y actinomicina d(acd); iii, el efecto del \u00e1cido all trans retinoico (atra), un agente inductor de ladiferenciaci\u00f3n, en la reversi\u00f3n del posible efecto protumoral de dichos fc y en lamejora de la eficacia antitumoral de la quimioterapia. Los resultados muestran que laqc con melfal\u00e1n, vcr y acd reduce la proliferaci\u00f3n de la l\u00ednea celular s4mh. Lapresencia de los fc se\u00f1alados estimula el crecimiento de dicha l\u00ednea tumoral y reducesignificativamente la actividad antitumoral del melfal\u00e1n, la vcr y la acd. Por otrolado, el atra ejerce un efecto antiproliferativo sobre la l\u00ednea s4mh, revierte el efectoprotumoral de los fc y mejora de forma significativa la eficacia antitumoral delmelfal\u00e1n, la vcr y la acd.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El \u00e1cido all trans retinoico reduce in vitro el efecto protumoral de los factores de crecimiento e incrementa la eficacia de la quimioterapia en el rabdomiosarcoma s4mh<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El \u00e1cido all trans retinoico reduce in vitro el efecto protumoral de los factores de crecimiento e incrementa la eficacia de la quimioterapia en el rabdomiosarcoma s4mh <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Roberto Sanisidro Torre <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/11\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Alonso Varona<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luisa Ugedo urruela <\/li>\n<li>Miguel Alcaraz ba\u00f1os (vocal)<\/li>\n<li>Juan  Francisco del Ca\u00f1izo l\u00f3pez (vocal)<\/li>\n<li>Mar\u00eda  bego\u00f1a Castro feo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Roberto Sanisidro Torre El rabdomiosarcoma (rms) es el sarcoma de partes blandas infantil m\u00e1s frecuente, conun mal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9399,1027,12909],"tags":[80928,186207,13466,230185,25026,230184],"class_list":["post-116646","post","type-post","status-publish","format-standard","hentry","category-cultivo-celular","category-oncologia","category-pais-vasco-euskal-herriko-unibertsitatea","tag-ana-alonso-varona","tag-juan-francisco-del-canizo-lopez","tag-luisa-ugedo-urruela","tag-maria-begona-castro-feo","tag-miguel-alcaraz-banos","tag-roberto-sanisidro-torre"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=116646"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116646\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=116646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=116646"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=116646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}