{"id":11666,"date":"2018-03-09T08:57:09","date_gmt":"2018-03-09T08:57:09","guid":{"rendered":""},"modified":"2018-03-09T08:57:09","modified_gmt":"2018-03-09T08:57:09","slug":"estudio-sobre-la-adminsitracion-de-interferon-alfa-ifn-alfa-y-ribavirina-como-retratamiento-en-pacientes-con-hepatitis-cronica-b-antihbe-positiva-analisis-de-la-proliferacion-especa%c2%adfica-de-li","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-sobre-la-adminsitracion-de-interferon-alfa-ifn-alfa-y-ribavirina-como-retratamiento-en-pacientes-con-hepatitis-cronica-b-antihbe-positiva-analisis-de-la-proliferacion-especa%c2%adfica-de-li\/","title":{"rendered":"Estudio sobre la adminsitraci\u00f3n de interfer\u00f3n alfa (ifn alfa) y ribavirina como retratamiento en pacientes con hepatitis cr\u00f3nica b antihbe positiva. an\u00e1lisis de la proliferaci\u00f3n espec\u00edfica de linfocitos t y de la secreci\u00f3n de citoquinas tras dicha terapia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Miguel Esteb\u00e1n L\u00f3pez-jamar <\/strong><\/h2>\n<p>Se estudian 24 pacientes con hepatitis cr\u00f3nica b antihbe positiva no respondedores a terapia previa con ifn. Fueron tratados con ifn a y ribavirina durante doce meses, realiz\u00e1ndose un seguimiento posterior de otros 12 meses. se estudi\u00f3 la respuesta terape\u00fatica y la proliferaci\u00f3n espec\u00edfica de linfocitos t en c\u00e9lulas mononucleares de sangre perif\u00e9rica (cmsp) y linfocitos t intrahep\u00e1ticos. adem\u00e1s se estudi\u00f3 la secreci\u00f3n de citoquinas tras dicha terapia.  resultados  se obtuvo una tasa de respuesta sostenida en 5 de los 24 pacientes (21%) al final del seguimiento (mes 24). S\u00f3lo presentaron mejor\u00eda histol\u00f3gica los pacientes con respuesta sostenida. Se observ\u00f3 respuesta proliferativa de linfocitos t frente a aghbe y aghbc a nivel intrahep\u00e1tico s\u00f3lo en pacientes con respueta sostenida (p=0,045), y aumento significativo de la proliferaci\u00f3n intrahep\u00e1tica de citoquinas de tipo th1 (ifn gamma e interleuquina 12) en pacientes con respuesta sostenida.  conclusiones  el tratamiento combinado con ifn a  y ribavirina en hepatitis cr\u00f3nica b antihbe que no respondieron a un tratamiento previo conifn:  1,- provoca un descenso significativo de la viremia y de las cifras de transaminasas.  2,- induce la respuesta espec\u00edfica de linfocitos t frente a ant\u00edgenos virales.  3,- induce la proliferaci\u00f3n intrahep\u00e1tica de citoquinas de tipo th 1 en c\u00e9lulas mononucleares de sangre perif\u00e9rica (cmsp) y linfocitos t intrahep\u00e1ticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio sobre la adminsitraci\u00f3n de interfer\u00f3n alfa (ifn alfa) y ribavirina como retratamiento en pacientes con hepatitis cr\u00f3nica b antihbe positiva. an\u00e1lisis de la proliferaci\u00f3n espec\u00edfica de linfocitos t y de la secreci\u00f3n de citoquinas tras dicha terapia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio sobre la adminsitraci\u00f3n de interfer\u00f3n alfa (ifn alfa) y ribavirina como retratamiento en pacientes con hepatitis cr\u00f3nica b antihbe positiva. an\u00e1lisis de la proliferaci\u00f3n espec\u00edfica de linfocitos t y de la secreci\u00f3n de citoquinas tras dicha terapia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Miguel Esteb\u00e1n L\u00f3pez-jamar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Diaz Rubio Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose De portugal  alvarez <\/li>\n<li>Jos\u00e9 Luis Bella sombria (vocal)<\/li>\n<li> Hererias gutierrez Juan  Manuel (vocal)<\/li>\n<li>Jaime Gosalbez verenguer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Miguel Esteb\u00e1n L\u00f3pez-jamar Se estudian 24 pacientes con hepatitis cr\u00f3nica b antihbe positiva no respondedores a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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