{"id":116829,"date":"2014-12-12T00:00:00","date_gmt":"2014-12-12T00:00:00","guid":{"rendered":""},"modified":"2014-12-12T00:00:00","modified_gmt":"2014-12-12T00:00:00","slug":"puesta-a-punto-de-modelos-in-vitro-de-barrera-hematoencefalica-y-pulmonar-para-su-aplicacion-en-estudios-toxicologicos-y-funcionales-en-nanomedicina-mise-au-point-de-moda%c2%a8les-in-vitro-de-barria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cultivo-celular\/puesta-a-punto-de-modelos-in-vitro-de-barrera-hematoencefalica-y-pulmonar-para-su-aplicacion-en-estudios-toxicologicos-y-funcionales-en-nanomedicina-mise-au-point-de-moda%c2%a8les-in-vitro-de-barria\/","title":{"rendered":"Puesta a punto de modelos in vitro de barrera hematoencef\u00e1lica y pulmonar para su aplicaci\u00f3n en estudios toxicol\u00f3gicos y funcionales en nanomedicina\/mise au point de mod\u00e9les in vitro de barri\u00e9re h\u00e9mat"},"content":{"rendered":"

Tesis doctoral de Alazne Dominguez Monedero <\/strong><\/h2>\n

Las nanopart\u00edculas, deben cumplir con los requerimientos de calidad, seguridad y eficacia quedicta la regulaci\u00f3n europea. Por ello, es necesario comprobar la capacidad de las nps paraatravesar las barreras fisiol\u00f3gicas y estudiar su toxicidad sobre el ser humano.En esta tesis doctoral se han estudiado diferentes modelos celulares in vitro de bhe y bp y suaplicabilidad en estudios funcionales y toxicol\u00f3gicos en farmacolog\u00eda y nanomedicina.Evaluando la seguridad y permeabilidad de diferentes nanopart\u00edculas aprovechando lacapacidad de los modelos in vitro desarrollados para observar las alteraciones producidas en laintegridad de sus barreras en presencia de un agente externo. Obteniendo a trav\u00e9s de esta tesisuna serie de ventajas:1.- Contar con unos modelos competitivos y que se asemejen funcionalmente a la bhe y bphumanas, y que permitan realizar estudios de penetraci\u00f3n, toxicidad y funcionalidad deproductos con diferentes finalidades.2.- Poseer la capacidad de predecir la penetraci\u00f3n de compuestos qu\u00edmicos y nanopart\u00edculas atrav\u00e9s de las bhe y bp y su potencial toxicidad sobre la integridad de las mismas.<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abPuesta a punto de modelos in vitro de barrera hematoencef\u00e1lica y pulmonar para su aplicaci\u00f3n en estudios toxicol\u00f3gicos y funcionales en nanomedicina\/mise au point de mod\u00e9les in vitro de barri\u00e9re h\u00e9mat<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Puesta a punto de modelos in vitro de barrera hematoencef\u00e1lica y pulmonar para su aplicaci\u00f3n en estudios toxicol\u00f3gicos y funcionales en nanomedicina\/mise au point de mod\u00e9les in vitro de barri\u00e9re h\u00e9mat <\/li>\n
  • Autor:<\/strong>\u00a0 Alazne Dominguez Monedero <\/li>\n
  • Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2014<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Felipe Go\u00f1i De Cerio<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Fernando jose Unda rodriguez <\/li>\n
        • salvador Borr\u00f3s g\u00f3mez (vocal)<\/li>\n
        • jordi Llop roig (vocal)<\/li>\n
        • prieta Candela — (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Alazne Dominguez Monedero Las nanopart\u00edculas, deben cumplir con los requerimientos de calidad, seguridad y eficacia quedicta la […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9399,12909],"tags":[230487,138721,143066,208242,230488,44045],"class_list":["post-116829","post","type-post","status-publish","format-standard","hentry","category-cultivo-celular","category-pais-vasco-euskal-herriko-unibertsitatea","tag-alazne-dominguez-monedero","tag-felipe-goni-de-cerio","tag-fernando-jose-unda-rodriguez","tag-jordi-llop-roig","tag-prieta-candela","tag-salvador-borros-gomez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=116829"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116829\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=116829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=116829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=116829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}