{"id":116876,"date":"2018-03-11T10:46:12","date_gmt":"2018-03-11T10:46:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-transferencia-de-saturacion-por-intercambio-qua%c2%admico-cest-en-nuevos-complejos-de-europio-iii\/"},"modified":"2018-03-11T10:46:12","modified_gmt":"2018-03-11T10:46:12","slug":"modulacion-de-la-transferencia-de-saturacion-por-intercambio-qua%c2%admico-cest-en-nuevos-complejos-de-europio-iii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estereoquimica-y-analisis-conformacional\/modulacion-de-la-transferencia-de-saturacion-por-intercambio-qua%c2%admico-cest-en-nuevos-complejos-de-europio-iii\/","title":{"rendered":"Modulaci\u00f3n de la transferencia de saturaci\u00f3n por intercambio qu\u00edmico (cest) en nuevos complejos de europio (iii)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Ana Andreieff Echeveste <\/strong><\/h2>\n<p>Actualmente, la resonancia magn\u00e9tica de imagen (rmi) es una de last\u00e9cnicas de diagnosis no agresivas m\u00e1s \u00fatil en medicina. Las im\u00e1genes deresonancia magn\u00e9tica se basan en la intensidad de la se\u00f1al de rmn del prot\u00f3n delas mol\u00e9culas de agua presentes en los tejidos y, en ciertos casos, es habitual eimprescindible el empleo de agentes de contraste para obtener im\u00e1genes de elevadacalidad. El \u00e9xito de estos productos, junto con el r\u00e1pido desarrollo de la t\u00e9cnica dermi, demanda una nueva generaci\u00f3n de agentes de contraste m\u00e1s eficaces yselectivos. En esta l\u00ednea, la presente tesis doctoral tiene por objeto el dise\u00f1o,s\u00edntesis y evaluaci\u00f3n del efecto cest (chemical exchange saturation transfer) denuevos complejos de eu(iii). Para ello se han dise\u00f1ado quimiotecas de nuevoscomplejos derivados de dtpa, dtta, do3a y dota conteniendo por una partefragmentos mim\u00e9ticos de plg, y por otra fragmentos de 1,2,3-triazol. Se ha llevadoa cabo la s\u00edntesis convergente de nuevos ligandos, introduciendo en sus esqueletosdiferencias tanto conformacionales y de carga, as\u00ed como en la longitud y lanaturaleza del espaciador empleado entre ambas unidades. El objetivo de dichasmodificaciones estructurales ha sido el de estudiar el efecto de la rigidez e hidrofiliadel ligando y de la compresi\u00f3n est\u00e9rica alrededor del ion lant\u00e1nido en los par\u00e1metrosque determinan la modulaci\u00f3n del efecto cest en los correspondientes complejosde eu3+. Se han realizado por vez primera estudios conformacionales en este tipo deagentes de contraste en disoluci\u00f3n empleando un amplio abanico de t\u00e9cnicasespectrosc\u00f3picas, adem\u00e1s de c\u00e1lculos de mec\u00e1nica molecular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la transferencia de saturaci\u00f3n por intercambio qu\u00edmico (cest) en nuevos complejos de europio (iii)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la transferencia de saturaci\u00f3n por intercambio qu\u00edmico (cest) en nuevos complejos de europio (iii) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Ana Andreieff Echeveste <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ignacio Miranda Murua<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Miguel Oyarbide garmendia <\/li>\n<li>Jes\u00fas hector Busto sanciri\u00e1n (vocal)<\/li>\n<li>raluca Mar\u00eda Fratila (vocal)<\/li>\n<li>daniel Padro hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Ana Andreieff Echeveste Actualmente, la resonancia magn\u00e9tica de imagen (rmi) es una de last\u00e9cnicas de diagnosis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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