{"id":116963,"date":"2018-03-11T10:46:17","date_gmt":"2018-03-11T10:46:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/distribution-of-stem-cells-inside-induced-gliomas-by-ethyl-nitrosurea\/"},"modified":"2018-03-11T10:46:17","modified_gmt":"2018-03-11T10:46:17","slug":"distribution-of-stem-cells-inside-induced-gliomas-by-ethyl-nitrosurea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neuroanatomia-humana\/distribution-of-stem-cells-inside-induced-gliomas-by-ethyl-nitrosurea\/","title":{"rendered":"Distribution of stem cells inside induced gliomas by ethyl-nitrosurea"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alvaro Garcia Blanco <\/strong><\/h2>\n<p>Los gliomas son tumores del sistema nervioso central de car\u00e1cter difuso y con una alta vascularizaci\u00f3n. Las c\u00e9lulas que gu\u00edan el crecimiento y expansi\u00f3n tumoral son las c\u00e9lulas madre tumorales que hay en el interior distribuidas preferentemente de forma perivascular. Mediante un modelo de generaci\u00f3n end\u00f3gena de gliomas hemos identificado las c\u00e9lulas madre tumorales y estudiado su distribuci\u00f3n a lo largo de los diferentes estadios de malignidad, desde su estado menos maligno hasta el m\u00e1s avanzado. Hemos observado la presencia de c\u00e9lulas madre tumorales alrededor de  la vascularizaci\u00f3n tumoral aberrante y una subpoblaci\u00f3n de c\u00e9lulas madre que se distribuyen en el interior del tumor formando agrupaci\u00f3n esferoides. Las c\u00e9lulas madre tumorales situadas de forma perivascular se encuentran en mayor cantidad en los vasos m\u00e1s aberrantes, como los glomerulos vasculares. Estas c\u00e9lulas madre est\u00e1n relacionadas con la angiogesis tumoral, al coexpresar factores como el vegf.Las agrupaciones esferoides aumentan en tama\u00f1o y numero seg\u00fan aumenta el grado de malignidad tumoral y comparten caracteristicas morfologicas e inmunohistoqu\u00edmicas con las neuroesferas obtenidas de gliomas. Estas agrupaciones esferoides son estructuras formadas por las c\u00e9lulas madre tumorales para defenderse en situaciones de hipoxia o falta de nutrientes.Por otro lado hemos utilizado un sistema de monitorizaci\u00f3n del comportamiento para identificar pautas que indiquen la presencia de un tumor del sistema nervioso central antes de la aparici\u00f3n de s\u00edntomas cl\u00ednicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Distribution of stem cells inside induced gliomas by ethyl-nitrosurea<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Distribution of stem cells inside induced gliomas by ethyl-nitrosurea <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alvaro Garcia Blanco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2014<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Vicente Lafuente Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: aurelio Ariza fern\u00e1ndez <\/li>\n<li>blanca Conde guerri (vocal)<\/li>\n<li>hari shanker Sharma &#8212; (vocal)<\/li>\n<li>i\u00f1igo cristobal Pomposo gaztelu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvaro Garcia Blanco Los gliomas son tumores del sistema nervioso central de car\u00e1cter difuso y con una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8868,12909],"tags":[230698,14039,13207,230699,183126,150020],"class_list":["post-116963","post","type-post","status-publish","format-standard","hentry","category-neuroanatomia-humana","category-pais-vasco-euskal-herriko-unibertsitatea","tag-alvaro-garcia-blanco","tag-aurelio-ariza-fernandez","tag-blanca-conde-guerri","tag-hari-shanker-sharma","tag-inigo-cristobal-pomposo-gaztelu","tag-jose-vicente-lafuente-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116963","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=116963"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/116963\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=116963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=116963"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=116963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}