{"id":11702,"date":"2018-03-09T08:57:12","date_gmt":"2018-03-09T08:57:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-suplementacion-dietetica-con-alfa-cetoglutarato-de-ormitina-sobre-el-funcionalismo-del-injerto-intestinal-en-un-modelo-de-trasplante-ortotopico-en-la-rata\/"},"modified":"2018-03-09T08:57:12","modified_gmt":"2018-03-09T08:57:12","slug":"efecto-de-la-suplementacion-dietetica-con-alfa-cetoglutarato-de-ormitina-sobre-el-funcionalismo-del-injerto-intestinal-en-un-modelo-de-trasplante-ortotopico-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-suplementacion-dietetica-con-alfa-cetoglutarato-de-ormitina-sobre-el-funcionalismo-del-injerto-intestinal-en-un-modelo-de-trasplante-ortotopico-en-la-rata\/","title":{"rendered":"Efecto de la suplementaci\u00f3n diet\u00e9tica con alfa-cetoglutarato de ormitina sobre el funcionalismo del injerto intestinal en un modelo de trasplante ortot\u00f3pico en la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carla Bettonica Larra\u00f1aga <\/strong><\/h2>\n<p>El trasplante intestinal provoca un da\u00f1o de la mucosa intestinal debido a los fen\u00f3menos de isquemia reperfusi\u00f3n que tienen lugar y que condicionan el fenomeno de traslocaci\u00f3n bacteriana. Por otro lado, el sobrecrecimiento bacteriano secundario a la denervaci\u00f3n intestinal tras el procedimiento y la imprescindible inmunosupresi\u00f3n requerida influyen en la elevada tasa de sepsis asociada al trasplante intestinal experimental y cl\u00ednico.  el alfa cetoglutarato de ornitina es un precursor de las poliaminas imprescindibles en los procesos de regeneraci\u00f3n y de diferenciaci\u00f3n tisulares y es tambi\u00e9n un precursor de la glutamina que al ser una importante fuente de energ\u00eda para el enterocito ha demostrado tener un efecto positivo sobre la funci\u00f3n intestinal en distintos modelos de trasplante intestinal experimental. en modelos de adaptaci\u00f3n intestinal tras resecci\u00f3n intestinal masiva y en modelos de isquemia entestinal el alfa cetoglutarato de ornitina ha demostrado tener un efecto tr\u00f3fico sobre la mucosa intestinal.  objetivos  1,- demostrar y cuantificar el efecto de un trasplante intestinal sobre la ruptura de la barrera intestinal.  2,- modular la disfunci\u00f3n de la barrera intestinal tras el trasplante intestinal mediante la administraci\u00f3n del alfa cetogluratato de ornitina.  3,- comparar los efectos que la suplementaci\u00f3n con alfa cetoglutarato de ornitina de una dieta tiene sobre la disfunci\u00f3n intestinal.  material y m\u00e9todos  se emplearon ratas lewis a las que practic\u00f3 un trasplante intestinal isog\u00e9nico y ortot\u00f3pico. Protocolo nutricional.  grupo 1: laparotomia + dieta impact.  grupo 2: laparotomia + pienso.  grupo 3: trasplante intestinal + dieta impact.  grupo 4: trasplante + pienso.  grupo 5: trasplante + pienso + aalfa cetoglutarato de ornitina.  grupo 6: trasplante intestinal + dieta impact + alfa cetoglutarato de ornitina.  sacrificio al 14\u00c2\u00ba d\u00eda para las siguientes determinaciones: ingesta, peso, co<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la suplementaci\u00f3n diet\u00e9tica con alfa-cetoglutarato de ormitina sobre el funcionalismo del injerto intestinal en un modelo de trasplante ortot\u00f3pico en la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la suplementaci\u00f3n diet\u00e9tica con alfa-cetoglutarato de ormitina sobre el funcionalismo del injerto intestinal en un modelo de trasplante ortot\u00f3pico en la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carla Bettonica Larra\u00f1aga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier De Oca Burguete<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduard Jaurrieta mas <\/li>\n<li>georgina Hotter (vocal)<\/li>\n<li>ricardo Lozano mantec\u00f3n (vocal)<\/li>\n<li>josep manel Llop talaver\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carla Bettonica Larra\u00f1aga El trasplante intestinal provoca un da\u00f1o de la mucosa intestinal debido a los fen\u00f3menos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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