{"id":117083,"date":"2018-03-11T10:46:27","date_gmt":"2018-03-11T10:46:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-neurovasculares-y-cognitivos-del-enriquecimiento-ambiental-tras-la-administracion-de-vandetanib-durante-el-desarrollo-postnatal-de-ratas-long-evans\/"},"modified":"2018-03-11T10:46:27","modified_gmt":"2018-03-11T10:46:27","slug":"efectos-neurovasculares-y-cognitivos-del-enriquecimiento-ambiental-tras-la-administracion-de-vandetanib-durante-el-desarrollo-postnatal-de-ratas-long-evans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurociencias\/efectos-neurovasculares-y-cognitivos-del-enriquecimiento-ambiental-tras-la-administracion-de-vandetanib-durante-el-desarrollo-postnatal-de-ratas-long-evans\/","title":{"rendered":"Efectos neurovasculares y cognitivos del enriquecimiento ambiental tras la administraci\u00f3n de vandetanib durante el desarrollo postnatal de ratas long evans"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irantzu Rico Barrio <\/strong><\/h2>\n<p>La cr\u00eda en un entorno enriquecido (ee) facilita la recuperaci\u00f3n de una lesi\u00f3n cerebral debido a importantes cambios corticales que se producen principalmente durante el periodo cr\u00edtico.Vandetanib (zd6474) se trata de un potente inhibidor de la tirosina kinasa que act\u00faa selectivamente bloqueando la se\u00f1alizaci\u00f3n mediada por el receptor vegfr-2, involucrado en procesos angiog\u00e9nicos as\u00ed como en procesos neurotr\u00f3ficos neurog\u00e9nicos y de neuroprotecci\u00f3n,. El objetivo de este estudio es analizar los efectos cognitivos y celulares de la administraci\u00f3n oral de vandetanib y el papel del ambiente enriquecido para contrarrestar los efectos de vandetanib durante el periodo cr\u00edtico de la rata.Para llevar a cabo el estudio, los animales fueron divididos en 3 grupos experimentales; controles criados en entornos est\u00e1ndar a los que se les administr\u00f3 un veh\u00edculo (sc-vh), controles criados en entornos est\u00e1ndar a los que se les administr\u00f3 un inhibidor (sci) y animales criados en entornos enriquecidos a los que se les administr\u00f3 un inhibidor (eei). Las administraciones y la cr\u00eda en ee, se llev\u00f3 a cabo desde p21 hasta p28.Los resultados mostraron una disminuci\u00f3n significativa de la densidad vascular, neuronal e interneuronal as\u00ed como un peor proceso de aprendizaje en el grupo de animales al que se le administr\u00f3 el inhibidor vandetanib (sci). La cr\u00eda de los animales en ee produjo una reversi\u00f3n de los efectos generados tras el bloqueo del receptor vegfr-2, observ\u00e1ndose un aumento significativo de las densidad vascular, neuronal e interneuronal, as\u00ed como una mejora de los animales de experimentaci\u00f3n en la prueba en aprendizaje visuoespacial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos neurovasculares y cognitivos del enriquecimiento ambiental tras la administraci\u00f3n de vandetanib durante el desarrollo postnatal de ratas long evans<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos neurovasculares y cognitivos del enriquecimiento ambiental tras la administraci\u00f3n de vandetanib durante el desarrollo postnatal de ratas long evans <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irantzu Rico Barrio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/01\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Harkaitz Bengoetxea Odriozola<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro rolando Grandes moreno <\/li>\n<li>isabel Portell cort\u00e9s (vocal)<\/li>\n<li>Jos\u00e9 Luis Trejo p\u00e9rez (vocal)<\/li>\n<li>carmen Martinez-cue pesini (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irantzu Rico Barrio La cr\u00eda en un entorno enriquecido (ee) facilita la recuperaci\u00f3n de una lesi\u00f3n cerebral [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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