{"id":117095,"date":"2015-04-02T00:00:00","date_gmt":"2015-04-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aneurisma-de-aorta-ascendente-y-valvula-aortica-comparacion-de-la-histologa%c2%ada-de-la-aorta-ascendente-en-pacientes-con-valvula-aortica-bicuspide-y-pacientes-con-valvula-aortica-tricuspide\/"},"modified":"2015-04-02T00:00:00","modified_gmt":"2015-04-02T00:00:00","slug":"aneurisma-de-aorta-ascendente-y-valvula-aortica-comparacion-de-la-histologa%c2%ada-de-la-aorta-ascendente-en-pacientes-con-valvula-aortica-bicuspide-y-pacientes-con-valvula-aortica-tricuspide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/aneurisma-de-aorta-ascendente-y-valvula-aortica-comparacion-de-la-histologa%c2%ada-de-la-aorta-ascendente-en-pacientes-con-valvula-aortica-bicuspide-y-pacientes-con-valvula-aortica-tricuspide\/","title":{"rendered":"Aneurisma de aorta ascendente y v\u00e1lvula a\u00f3rtica: comparaci\u00f3n de la histolog\u00eda de la aorta ascendente en pacientes con v\u00e1lvula a\u00f3rtica bic\u00faspide y pacientes con v\u00e1lvula a\u00f3rtica tric\u00faspide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Victoria Ca\u00f1adas Godoy <\/strong><\/h2>\n<p>Introducci\u00f3n: la v\u00e1lvula a\u00f3rtica bic\u00faspide (vab) es la cardiopat\u00eda cong\u00e9nita m\u00e1s frecuente y afecta al 0,5-2 por ciento de la poblaci\u00f3n. Los pacientes con vab tienen mayor predisposici\u00f3n al desarrollo de dilataci\u00f3n a\u00f3rtica, conocido factor de riesgo para el desarrollo de disecci\u00f3n y-o rotura a\u00f3rtica. Los mecanismos que conducen a la dilataci\u00f3n a\u00f3rtica en estos pacientes no son bien conocidos, pero podr\u00edan relacionarse con una debilidad estructural cong\u00e9nita en la pared a\u00f3rtica (aortopat\u00eda bic\u00faspide). La hip\u00f3tesis de este trabajo es que los aneurismas que se desarrollan en el seno de una vab deber\u00edan presentar caracter\u00edsticas histol\u00f3gicas distintivas respecto a los que aparecen en los pacientes con v\u00e1lvula a\u00f3rtica tric\u00faspide (vat). M\u00e9todos: se incluyeron de forma prospectiva 134 pacientes (75 por ciento varones, edad media 63 a\u00f1os) sometidos a cirug\u00eda electiva sobre la aorta ascendente y se clasificaron en dos grupos en funci\u00f3n de la morfolog\u00eda valvular. Se obtuvieron muestras de aorta ascendente durante la intervenci\u00f3n y se estudiaron los siguientes aspectos histol\u00f3gicos: grosor total de la capa media, patr\u00f3n de vascularizaci\u00f3n de la capa media y los cambios degenerativos (fibrosis, fragmentaci\u00f3n de las fibras el\u00e1sticas, necrosis qu\u00edstica de la media y calcificaci\u00f3n). Se construyeron adem\u00e1s modelos de regresi\u00f3n para estudiar el impacto de otras variables cl\u00ednicas en los hallazgos histol\u00f3gicos. Resultados: no se encontraron diferencias en cuanto al grosor de la capa media entre los dos grupos de pacientes. Los pacientes con vat mostraron una vascularizaci\u00f3n m\u00e1s rica de la capa media, caracterizada por una mayor profundidad de penetraci\u00f3n de los vasa vasorum. Adem\u00e1s presentaron mayor grado de fibrosis y de fragmentaci\u00f3n de las fibras el\u00e1sticas, pero no se encontraron diferencias entre los dos grupos en cuanto a la necrosis qu\u00edstica de la media o la presencia de calcificaci\u00f3n en la capa media. En el an\u00e1lisis multivariado la morfolog\u00eda valvular fue predictor independiente de la penetraci\u00f3n de los vasa vasorum, pero no de los cambios degenerativos analizados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aneurisma de aorta ascendente y v\u00e1lvula a\u00f3rtica: comparaci\u00f3n de la histolog\u00eda de la aorta ascendente en pacientes con v\u00e1lvula a\u00f3rtica bic\u00faspide y pacientes con v\u00e1lvula a\u00f3rtica tric\u00faspide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aneurisma de aorta ascendente y v\u00e1lvula a\u00f3rtica: comparaci\u00f3n de la histolog\u00eda de la aorta ascendente en pacientes con v\u00e1lvula a\u00f3rtica bic\u00faspide y pacientes con v\u00e1lvula a\u00f3rtica tric\u00faspide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Victoria Ca\u00f1adas Godoy <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/02\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isidre Vilacosta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Ladero quesada <\/li>\n<li>Fernando Alfonso manterola (vocal)<\/li>\n<li>Luis Carlos Maroto castellanos (vocal)<\/li>\n<li>Luis Antonio Alonso pulpon rivera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Victoria Ca\u00f1adas Godoy Introducci\u00f3n: la v\u00e1lvula a\u00f3rtica bic\u00faspide (vab) es la cardiopat\u00eda cong\u00e9nita m\u00e1s frecuente y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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