{"id":117202,"date":"2018-03-11T10:46:37","date_gmt":"2018-03-11T10:46:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-salud-circadiana-como-factor-predictivo-de-exito-en-la-perdida-de-peso\/"},"modified":"2018-03-11T10:46:37","modified_gmt":"2018-03-11T10:46:37","slug":"analisis-de-la-salud-circadiana-como-factor-predictivo-de-exito-en-la-perdida-de-peso","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-humana\/analisis-de-la-salud-circadiana-como-factor-predictivo-de-exito-en-la-perdida-de-peso\/","title":{"rendered":"An\u00e1lisis de la salud circadiana como factor predictivo de \u00e9xito en la p\u00e9rdida de peso."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Cristina Bandin Saura <\/strong><\/h2>\n<p>Objetivos: objetivo 1: investigar la relaci\u00f3n entre la p\u00e9rdida de peso y la ritmicidad circadiana, utilizando la temperatura de la mu\u00f1eca y mediciones de actimetr\u00eda, en mujeres sometidas a un programa de p\u00e9rdida de peso, con el fin de evaluar si la ritmicidad circadiana pudiera ser un marcador de la eficacia de los tratamientos de p\u00e9rdida de peso. objetivo 2: investigar los efectos de los cambios en el horario de las comidas sobre el gasto de energ\u00eda, la tolerancia a la glucosa y variables circadianas.  objetivo 3: determinar, si la presencia de clock 3111t\/c en mujeres con sobrepeso  est\u00e1 relacionado con (a) trastornos circadianos, y (b) cambios en la calidad del sue\u00f1o, para mejorar la comprensi\u00f3n de las asociaciones previamente demostradas con la obesidad y la reducci\u00f3n de la p\u00e9rdida de peso de las portadoras c.  metodos: i.\tPara la consecuci\u00f3n del objetivo 1: participaron 85 mujeres ( imc: 30.24 \u00c2\u00b1 4.95 kgm-2) sometidas a un programa de reducci\u00f3n de peso. La eficacia del tratamiento se defini\u00f3 mediante: la p\u00e9rdida de peso total, el porcentaje de p\u00e9rdida de peso respecto al peso inicial y la p\u00e9rdida de peso semanal. La ritmicidad circadiana se determin\u00f3 mediante: temperatura de la mu\u00f1eca, actividad motora y posici\u00f3n del cuerpo. ii.\tPara la consecuci\u00f3n del objetivo 2: 32 mujeres [edad 24 \u00c2\u00b1 4 e imc 22,9 \u00c2\u00b1 2,6 kg\/m2] participaron en este estudi\u00f3. Se dise\u00f1aron dos protocolos de forma aleatoria y cruzada. Para el protocolo (p1) (n = 10) se realizaron medidas de gasto energ\u00e9tico en reposo mediante calorimetr\u00eda indirecta y tolerancia a la glucosa durante el periodo postprandial, para el protocolo (p2) se incluyeron mediciones relacionadas con el sistema circadiano basados en perfiles de cortisol salivar y temperatura medida en la mu\u00f1eca (n = 22). A los participantes se les proporcion\u00f3 comidas estandarizadas durante las dos semanas de intervenci\u00f3n y se estudiaron bajo dos condiciones: comiendo temprano (13:00h) y comiendo tarde (16:30h).  iii.\tPara la consecuci\u00f3n del objetivo 3: se reclutaron 85 mujeres con sobrepeso, [edad 43 \u00c2\u00b1 12 e imc 28,6 \u00c2\u00b14,3 kg\/m2]. Las variables de temperatura de mu\u00f1eca (t), actimetr\u00eda (a), posici\u00f3n del cuerpo (p) y tap se midieron como marcadores de la funcionalidad sistema circadiano. Se complet\u00f3 un cuestionario de actividad, un registro de comida y sue\u00f1o diario, mientras que la calidad del sue\u00f1o se determin\u00f3 mediante polisomnograf\u00eda domiciliaria. De esta muestra, 43 mujeres portaban el snp del alelo menor (c) para clock 3111 y 42 mujeres eran no portadoras de dicho alelo (tt). Ambos grupos de pacientes estaban igualados en n\u00famero, edad, par\u00e1metros de obesidad e ingesta de energ\u00eda.   conclusiones: [i] los ritmos circadianos en el inicio del tratamiento son buenos indicadores de la futura p\u00e9rdida de peso. El tratamiento adicional debe considerar aspectos cronobiol\u00f3gicos para diagnosticar la obesidad y la eficacia de los tratamientos. [ii] comer tarde se asoci\u00f3 con una disminuci\u00f3n del gasto energ\u00e9tico en reposo, una disminuci\u00f3n de la oxidaci\u00f3n de carbohidratos en ayunas, disminuci\u00f3n de tolerancia a la glucosa, con un perfil diario m\u00e1s aplanado en las concentraciones de cortisol libre y una disminuci\u00f3n del efecto t\u00e9rmico de los alimentos seg\u00fan la temperatura perif\u00e9rica medida en la mu\u00f1eca. Estos resultados pueden estar implicados en los efectos diferenciales de horario de las comidas en la salud metab\u00f3lica. [iii] individuos portadores del alelo menor c del clock 3111 presentan un ritmo circadiano menos robusto que el tt y una acrofase retrasada que caracteriza a los sujetos con cronotipo vespertino. Apoyamos la idea de que la identificaci\u00f3n de genotipos de reloj en los pacientes puede ayudar al terapeuta en la caracterizaci\u00f3n de las ra\u00edces del problema metab\u00f3lico.    objectives: objective 1: to investigate the potential relationship between weight loss and circadian rhythmicity, using wrist temperature and actimetry measurements, in women undergoing a weight-loss program, in order to assess whether circadian rhythmicity could be a marker of weight-loss effectiveness. objective 2: to investigate the effects of changes in meal timing on energy-expenditure, glucose-tolerance and circadian-related variables. objective 3: determine, in free-living conditions, if the presence of clock 3111c in overweight women could be related to (a) circadian disorders, and (b) changes in sleep quality, to improve understanding of the previously demonstrated associations with obesity and reduced weight loss of the c carriers.  methods: i.\tTo get the objective 1: participants were 85 overweight and obese women (body mass index, bmi: 30.24\u00c2\u00b14.95 kg m-2) subjected to a weight reduction program. Efficacy of the treatment was defined as total weight loss, percentage of initial weight and weekly weight loss rates. Circadian rhythmicity in wrist temperature motor activity and position were analyzed using different sensors.  ii.\tTo get the objective 2: thirty-two women (aged 24 \u00c2\u00b1 4 years and body mass index 22.9 \u00c2\u00b1 2.6 kgm? 2) completed two randomized, crossover protocols: one protocol (p1) including assessment of resting-energy expenditure (indirect-calorimetry) and glucose tolerance (mixed-meal test) (n = 10), the other (p2) including circadian-related measurements based on profiles in salivary cortisol and wrist temperature (twrist) (n = 22). In each protocol, participants were provided with standardized meals (breakfast, lunch and dinner) during the two meal intervention weeks and were studied under two lunch-eating conditions: early eating (ee; lunch at 13:00) and late eating (le; lunch 16:30). iii.\tTo get the objective 3: wrist temperature, actimetry and position (tap) and tap variables were measured as markers of circadian functionality during 8 consecutive days. A rest-activity and food diary was also completed, whereas sleep quality was determined by domiciliary polysomnography. We recruited 85 women who were overweight with body mass index (bmi) of 28.59\u00c2\u00b14.30 kg m-2 and age 43\u00c2\u00b112 years. From this sample, we found that 43 women were carrying the minor allele (c) for clock 3111t\/c snp and 42 women were tt carriers (major allele carriers). Both groups of patients were matched for number, age, obesity parameters and energy intake.  conclusions: [i] circadian rhythms at the beginning of the treatment are good predictors of future weight loss. Further treatment should consider chronobiological aspects to diagnose obesity and effectiveness of treatments. [ii] eating late is associated with decreased resting-energy expenditure, decreased fasting carbohydrate oxidation, decreased glucose tolerance, blunted daily profile in free cortisol concentrations and decreased thermal effect of food on twrist. These results may be implicated in the differential effects of meal timing on metabolic health. [iii] c genetic variants in clock 3111t\/c display a less robust circadian rhythm than tt and a delayed acrophase that characterizes &apos;evening-type&apos; subjects. We support the notion that identifying clock genotypes in patients may assist the therapist in characterization of the roots of the metabolic problem.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la salud circadiana como factor predictivo de \u00e9xito en la p\u00e9rdida de peso.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la salud circadiana como factor predictivo de \u00e9xito en la p\u00e9rdida de peso. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Cristina Bandin Saura <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Garaulet Aza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 enrique Campillo \u00e1lvarez <\/li>\n<li>Mar\u00eda carmen Collado amores (vocal)<\/li>\n<li>Mar\u00eda Izquierdo pulido (vocal)<\/li>\n<li>Antonio Garcia rios (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Cristina Bandin Saura Objetivos: objetivo 1: investigar la relaci\u00f3n entre la p\u00e9rdida de peso y la 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