{"id":117204,"date":"2018-03-11T10:46:37","date_gmt":"2018-03-11T10:46:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/role-of-matrix-metalloproteinase-10-after-hindlimb-ischemia\/"},"modified":"2018-03-11T10:46:37","modified_gmt":"2018-03-11T10:46:37","slug":"role-of-matrix-metalloproteinase-10-after-hindlimb-ischemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/role-of-matrix-metalloproteinase-10-after-hindlimb-ischemia\/","title":{"rendered":"Role of matrix metalloproteinase-10 after hindlimb ischemia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Violeta G\u00f3mez Rodr\u00edguez <\/strong><\/h2>\n<p>The main finding of the thesis is that matrix metalloproteinase-10 (mmp-10) is neccesary for skeletal muscle repair after hypoxia, as the absence of mmp-10 results in delayed reperfusion, increased necrosis and inflammation during the degenerative phase, which is associated later with delayed vessel regression and myocyte regeneration. We propose the regulation of the chemokine cxcl1 by mmp-10 as one of the possible mechanisms involved in the delayed regeneration present in mmp10-\/- mice. This study underscores, for the first time, the relevance of mmp-10 after ischemia as a new pathophysiological mechanism in diseases characterized by a shortage of oxygen and nutrient delivery to the skeletal muscle such as peripheral arterial disease.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Role of matrix metalloproteinase-10 after hindlimb ischemia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Role of matrix metalloproteinase-10 after hindlimb ischemia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Violeta G\u00f3mez Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Paramo Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guillermo Zalba go\u00f1i <\/li>\n<li>Jos\u00e9 Luis Martin ventura (vocal)<\/li>\n<li>anna Rosell novel (vocal)<\/li>\n<li>rienk Nieuwland (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Violeta G\u00f3mez Rodr\u00edguez The main finding of the thesis is that matrix metalloproteinase-10 (mmp-10) is neccesary for [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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