{"id":117210,"date":"2015-03-03T00:00:00","date_gmt":"2015-03-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-las-bases-fisiopatogenicas-y-revision-sistematica-del-tratamiento-de-la-esofagitis-eosinofa%c2%adlica-en-pacientes-refractarios\/"},"modified":"2015-03-03T00:00:00","modified_gmt":"2015-03-03T00:00:00","slug":"analisis-de-las-bases-fisiopatogenicas-y-revision-sistematica-del-tratamiento-de-la-esofagitis-eosinofa%c2%adlica-en-pacientes-refractarios","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/gastroenterologia\/analisis-de-las-bases-fisiopatogenicas-y-revision-sistematica-del-tratamiento-de-la-esofagitis-eosinofa%c2%adlica-en-pacientes-refractarios\/","title":{"rendered":"An\u00e1lisis de las bases fisiopatog\u00e9nicas y revisi\u00f3n sistem\u00e1tica del tratamiento de la esofagitis eosinof\u00edlica en pacientes refractarios"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Moreno Borque <\/strong><\/h2>\n<p>La esofagitis eosinof\u00edlica (ee) es una enfermedad cr\u00f3nica de etiolog\u00eda desconocida. La infiltraci\u00f3n por eosin\u00f3filos sugiere que se deba a mecanismos al\u00e9rgicos, responsables de inflamaci\u00f3n y cambios estructurales. Las dietas y los corticoides son terapias de primera l\u00ednea que mejoran los s\u00edntomas y la histolog\u00eda, aunque pueden causar efectos adversos, intolerancia y ausencia de respuesta. Por esto se est\u00e1n ensayando tratamientos experimentales biol\u00f3gicos. Objetivos: i. Analizar los s\u00edntomas de presentaci\u00f3n, las pautas diagn\u00f3sticas y los mecanismos patog\u00e9nicos; ii. Analizar mediante revisi\u00f3n sistem\u00e1tica (rs) la utilidad de las terapias biol\u00f3gicas en pacientes refractarios; y iii. Establecer un posible \u00edndice para evaluar la actividad de la ee. M\u00e9todos: estudio de las caracter\u00edsticas cl\u00ednicas de pacientes con ee (25) y controles (21) con reflujo gastroesof\u00e1gico. Para los an\u00e1lisis de rs (patog\u00e9nesis, tratamientos e \u00edndice de actividad) las publicaciones se identificaron mediante buscadores electr\u00f3nicos combinando t\u00e9rminos mesh y palabras clave espec\u00edficas. Resultados: la edad media de los pacientes con ee fue de 36 a\u00f1os, la mayor\u00eda (96%) eran varones y aquejaban disfagia al inicio. La endoscopia detect\u00f3 cambios estructurales responsables de impactaci\u00f3n esof\u00e1gica y la histolog\u00eda evidenci\u00f3 el infiltrado eosin\u00f3filo. Estos datos apoyan una patog\u00e9nesis por hipersensibilidad al\u00e9rgica, aunque no se conocen los al\u00e9rgenos inhalados ni ingeridos. En la rs se incluyen 639 pacientes tratados, con respuestas cl\u00ednica (61%) e histol\u00f3gica (58%) moderadas. Conclusiones: las tasas de eficacia de las terapias biol\u00f3gicas son discretas, estando aun por definir su eficacia y seguridad reales mediante estudios controlados. Solo unos niveles bajos de eosin\u00f3filos circulantes se correlacionan con la actividad de la ee<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de las bases fisiopatog\u00e9nicas y revisi\u00f3n sistem\u00e1tica del tratamiento de la esofagitis eosinof\u00edlica en pacientes refractarios<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de las bases fisiopatog\u00e9nicas y revisi\u00f3n sistem\u00e1tica del tratamiento de la esofagitis eosinof\u00edlica en pacientes refractarios <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Moreno Borque <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/03\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Cecilio Santander Vaquero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Zaragoza garcia <\/li>\n<li>esteban Daud\u00e9n tello (vocal)<\/li>\n<li>Luisa consuelo Garc\u00eda buey (vocal)<\/li>\n<li>Antonio Ruiz de le\u00f3n san Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Moreno Borque La esofagitis eosinof\u00edlica (ee) es una enfermedad cr\u00f3nica de etiolog\u00eda desconocida. La infiltraci\u00f3n por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,1957,491,2272],"tags":[190961,190962,92336,4080,202841,231067],"class_list":["post-117210","post","type-post","status-publish","format-standard","hentry","category-alcala","category-alergias","category-gastroenterologia","category-interaccion-de-antigenos","tag-antonio-ruiz-de-leon-san-juan","tag-cecilio-santander-vaquero","tag-esteban-dauden-tello","tag-francisco-zaragoza-garcia","tag-luisa-consuelo-garcia-buey","tag-ricardo-moreno-borque"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/117210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=117210"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/117210\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=117210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=117210"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=117210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}