{"id":117250,"date":"2015-11-03T00:00:00","date_gmt":"2015-11-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/busqueda-de-compuestos-antiamiloidogenicos-con-potencial-terapeutico-en-la-enfermedad-de-alzheimer\/"},"modified":"2015-11-03T00:00:00","modified_gmt":"2015-11-03T00:00:00","slug":"busqueda-de-compuestos-antiamiloidogenicos-con-potencial-terapeutico-en-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/busqueda-de-compuestos-antiamiloidogenicos-con-potencial-terapeutico-en-la-enfermedad-de-alzheimer\/","title":{"rendered":"B\u00fasqueda de compuestos antiamiloidog\u00e9nicos con potencial terap\u00e9utico en la enfermedad de alzheimer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Karim Lizeth Jimenez Aliaga <\/strong><\/h2>\n<p>Uno de los eventos clave de la enfermedad de alzheimer (ea) es la alteraci\u00f3n del procesamiento de la prote\u00edna precursora del beta-amiloide (app), que plantea la hip\u00f3tesis de \u00c2\u00bfla cascada amiloide\u00c2\u00bf por la que se establece que la oligomerizaci\u00f3n y\/o agregaci\u00f3n del p\u00e9ptido beta-amiloide (\u00edYa) es el evento de activaci\u00f3n de diferentes v\u00edas de neurodegeneraci\u00f3n como estr\u00e9s oxidativo, neuroinflamaci\u00f3n y apoptosis, conduciendo finalmente a la muerte neuronal. Sobre la base de las distintas v\u00edas de neurodegeneraci\u00f3n provocada por el betaa, diferentes estudios han determinado que los compuestos polifen\u00f3licos podr\u00edan actuar como ligandos en diferentes dianas farmacol\u00f3gicas. En este sentido, resulta interesante la b\u00fasqueda de compuestos flav\u00f3nicos con capacidad neuroprotectora, en particular con actividad antiamiloidog\u00e9nica, con el fin de aportar compuestos multidiana potencialmente activos y eficaces en la prevenci\u00f3n de la ea.Se han evaluado seis compuestos pertenecientes a diferentes grupos de flavonoides, flavonoles (quercetina, rutina y troxerutina), flavonas (diosmina e hidrosmina) y flavanonas (naringina), con el objetivo de estudiar su potencial capacidad antiamiloidog\u00e9nica. El estudio se ha llevado a cabo en tres niveles experimentales: a) ensayos in vitro; b) l\u00ednea celular transg\u00e9nica de neuroblastoma appswe y; c)  rat\u00f3n transg\u00e9nico tg2576 que sobreexpresa la appswe humana.Las pruebas in vitro permitieron seleccionar quercetina y rutina como los compuestos m\u00e1s activos. En la l\u00ednea celular, ambos flavonoides influyeron positivamente sobre el sistema antioxidante, los mecanismos antiapopt\u00f3tico y antiamiloidog\u00e9nico y, a nivel del proteasoma. En los ratones tg2576 se hizo evidente un marcado estr\u00e9s oxidativo, apopt\u00f3tico y neuroinflamatorio, caracter\u00edstico de la fase temprana de la ea, que fue revertido en mayor o menor grado con los tratamientos de quercetina y rutina.En conclusi\u00f3n, tanto rutina como quercetina podr\u00edan prevenir varias manifestaciones observadas en la ea debido a que han demostrado propiedades beneficiosas sobre m\u00faltiples dianas farmacol\u00f3gicas evaluadas en diferentes modelos de estudio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>B\u00fasqueda de compuestos antiamiloidog\u00e9nicos con potencial terap\u00e9utico en la enfermedad de alzheimer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 B\u00fasqueda de compuestos antiamiloidog\u00e9nicos con potencial terap\u00e9utico en la enfermedad de alzheimer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Karim Lizeth Jimenez Aliaga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/03\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan a Benedi Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: irene Iglesias peinado <\/li>\n<li>Mar\u00eda  Jos\u00e9 Gonzalez mu\u00f1oz (vocal)<\/li>\n<li>Mar\u00eda del carmen Lozano  estevan (vocal)<\/li>\n<li>Mar\u00eda teresa Mart\u00edn l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Karim Lizeth Jimenez Aliaga Uno de los eventos clave de la enfermedad de alzheimer (ea) es la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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