{"id":11743,"date":"2018-03-09T08:57:15","date_gmt":"2018-03-09T08:57:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-inhibicion-de-la-sa%c2%adntesis-de-colesterol-sobre-la-actividad-del-receptor-ldl-y-la-proliferacion-celular-in-vitro\/"},"modified":"2018-03-09T08:57:15","modified_gmt":"2018-03-09T08:57:15","slug":"efectos-de-la-inhibicion-de-la-sa%c2%adntesis-de-colesterol-sobre-la-actividad-del-receptor-ldl-y-la-proliferacion-celular-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efectos-de-la-inhibicion-de-la-sa%c2%adntesis-de-colesterol-sobre-la-actividad-del-receptor-ldl-y-la-proliferacion-celular-in-vitro\/","title":{"rendered":"Efectos de la inhibici\u00f3n de la s\u00edntesis de colesterol sobre la actividad del receptor ldl y la proliferaci\u00f3n celular \u00abin vitro\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yajaira Su\u00e1rez Delgado <\/strong><\/h2>\n<p>El colesterol, adem\u00e1s de ser el precursor de las hormonas estero\u00eddicas y \u00e1cidos biliares, es una mol\u00e9cular esencial para las c\u00e9lulas de mam\u00edferos al ser uno de los principales componentes de la membrana plasm\u00e1tica, siendo necesaria en los procesos de embriog\u00e9nesis y de proliferaci\u00f3n celular. en este \u00fatlimo caso, el colesterol no se limita a ser un componente estructural sino que ejerce un papel regulador del ciclo celular, permitiendo la transici\u00f3n de g2 a mitosis. La importancia del colesterol para la biolog\u00eda celular explica que las c\u00e9lulas proliferantes presenten una alta tasa de s\u00edntesis de colesterol as\u00ed como una elevada actividad del receptor ldl. Es por ello que en esta tesis doctoral se ha profundizado en el conocimiento de las relaciones entre el metabolismo del colesterol, el receptor ldl y la proliferaci\u00f3n celular.  se han determinado las relaciones entre la funcionalidad del receptor ldl y la proliferaci\u00f3n celular, mediante dos tipos de ensayos funcionales en linfocitos de pacientes con hipercolesterolemia.  se ha determinado el efecto de la disponibilidad de colesterol as\u00ed como de sus precursores no estero\u00eddicos sobre la actividad del receptor ldl. y la proliferaci\u00f3n celular, mediante el empleo de distintos inhibidores de la colesterog\u00e9nesis, lo que ha permitido establecer que la inhibici\u00f3n de la colesterog\u00e9nesis produce una estimulaci\u00f3n del receptor ldl siempre y cuando no se comprometa la s\u00edntesis de mevalonato y de sus derivados no estero\u00eddicos, ya que lo contrario produce una disminuci\u00f3n de la actividad del receptor ldl que se acompa\u00f1a de una inhibici\u00f3n de la proliferaci\u00f3n celular.  se ha profundizado en los mecanismos hipolipemiantes del tamoxifeno, mediante el estudio de sus efectos sobre la expresi\u00f3n y la actividad del receptor ldl y su relaci\u00f3n con la proliferaci\u00f3n celular. As\u00ed se ha observado que \u00e9ste produce una estimulaci\u00f3n del receptor ldl, que se manterializa en un aumento d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la inhibici\u00f3n de la s\u00edntesis de colesterol sobre la actividad del receptor ldl y la proliferaci\u00f3n celular \u00abin vitro\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la inhibici\u00f3n de la s\u00edntesis de colesterol sobre la actividad del receptor ldl y la proliferaci\u00f3n celular \u00abin vitro\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yajaira Su\u00e1rez Delgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel \u00e1ngel Lasunci\u00f3n Ripa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cecilio Gimenez martin <\/li>\n<li>Miguel Pocovi mieras (vocal)<\/li>\n<li> De owa otero Manuel (vocal)<\/li>\n<li>agust\u00edn Montes duarte (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yajaira Su\u00e1rez Delgado El colesterol, adem\u00e1s de ser el precursor de las hormonas estero\u00eddicas y \u00e1cidos biliares, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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