{"id":117653,"date":"2018-03-11T10:47:18","date_gmt":"2018-03-11T10:47:18","guid":{"rendered":""},"modified":"2018-03-11T10:47:18","modified_gmt":"2018-03-11T10:47:18","slug":"actividad-in-vitro-de-anidulafungina-caspofungina-y-micafungina-contra-especies-cra%c2%adpticas-de-candida-curvas-de-letalidad-efecto-postantifungico-y-modelizacion-farmacocinetica-farmacodinamica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/actividad-in-vitro-de-anidulafungina-caspofungina-y-micafungina-contra-especies-cra%c2%adpticas-de-candida-curvas-de-letalidad-efecto-postantifungico-y-modelizacion-farmacocinetica-farmacodinamica\/","title":{"rendered":"Actividad in vitro de anidulafungina, caspofungina y micafungina contra especies cr\u00edpticas de candida: curvas de letalidad, efecto postantif\u00fangico y modelizaci\u00f3n farmacocin\u00e9tica\/farmacodin\u00e1mica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sandra Gil Alonso <\/strong><\/h2>\n<p>Las candidiasis son las micosis invasivas m\u00c2\u00bfs frecuentes y una importante causa de morbilidad ymortalidad. Candida albicans es la especie predominante pero otras especies de este g\u00c2\u00bfnero la est\u00c2\u00bfndesplazando etiol\u00c2\u00bfgicamente, modificando el patr\u00c2\u00bfn epidemiol\u00c2\u00bfgico de las candidiasis invasivas.Adem\u00c2\u00bfs las candidemias causadas por estas especies pueden ser m\u00c2\u00bfs graves por la presencia deresistencias microbiol\u00c2\u00bfgicas a fluconazol y a otros f\u00c2\u00bfrmacos antif\u00c2\u00bfngicos. Por otro lado, el patr\u00c2\u00bfn desensibilidad a los f\u00c2\u00bfrmacos antif\u00c2\u00bfngicos de las nuevas especies cr\u00c2\u00bfpticas de los complejos de especies decandida albicans, candida glabrata y candida parapsilosis no est\u00c2\u00bf bien establecido, haci\u00c2\u00bfndose necesario elestudio del comportamiento de los f\u00c2\u00bfrmacos contras estas especies.Por todo ello, resulta imprescindible disponer de m\u00c2\u00bftodos de estudio in vitro adecuados, como lascurvas de letalidad, que permitan evaluar y comparar la eficacia antif\u00c2\u00bfngica de los f\u00c2\u00bfrmacos. Adem\u00c2\u00bfs elestudio del efecto postantif\u00c2\u00bfngico, podr\u00c2\u00bfa ser importante para el dise\u00c2\u00bfo de los reg\u00c2\u00bfmenes dedosificaci\u00c2\u00bfn terap\u00c2\u00bfutica, al permitir espaciar las dosis de los f\u00c2\u00bfrmacos antif\u00c2\u00bfngicos que han mostradoefecto postantif\u00c2\u00bfngico prolongado frente a determinadas cepas. Como valor a\u00c2\u00bfadido, se pueden utilizarlos modelos matem\u00c2\u00bfticos farmacocin\u00c2\u00bfticos\/farmacodin\u00c2\u00bfmicos basados en datos de letalidad, junto condatos farmacocin\u00c2\u00bfticos de humanos, para simular el perfil de letalidad correspondiente a un r\u00c2\u00bfgimendeterminado de dosificaci\u00c2\u00bfn del f\u00c2\u00bfrmaco. En este trabajo se ha evaluado la eficacia in vitro de un gruporeciente de f\u00c2\u00bfrmacos antif\u00c2\u00bfngicos, las equinocandinas, anidulafungina, caspofungina y micafungina,contra las especies cr\u00c2\u00bfpticas del g\u00c2\u00bfnero candida.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad in vitro de anidulafungina, caspofungina y micafungina contra especies cr\u00edpticas de candida: curvas de letalidad, efecto postantif\u00fangico y modelizaci\u00f3n farmacocin\u00e9tica\/farmacodin\u00e1mica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad in vitro de anidulafungina, caspofungina y micafungina contra especies cr\u00edpticas de candida: curvas de letalidad, efecto postantif\u00fangico y modelizaci\u00f3n farmacocin\u00e9tica\/farmacodin\u00e1mica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sandra Gil Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2015<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Nerea Jaureguizar Albondigamayor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 pedro De la cruz cort\u00e9s <\/li>\n<li>josep Guarro artigas (vocal)<\/li>\n<li>Elena Eraso barrio (vocal)<\/li>\n<li>emilia Canton lacasa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sandra Gil Alonso Las candidiasis son las micosis invasivas m\u00c2\u00bfs frecuentes y una importante causa de morbilidad 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